Robert M. CornProfessor, Chemistry |
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Research Interests |
Surface Chemistry, Surface Spectroscopy, Metal and Magnetic Nanoparticle Materials, Biosensors, DNA at Surfaces, SPR, FTIR, Diffraction | |
| URL | corninfo.ps.uci.edu | |
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Academic Distinctions |
2007 Pittsburgh Spectroscopy Award 2007 ACS Division of Analytical Chemistry Award in Spectrochemical Analysis 2007 AAAS Fellow |
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| Appointments | Visiting Scientist at the IBM Research Laboratory in San Jose, California, 1983-1984 | |
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Research Abstract |
Professor Corn's area of expertise is the study of chemistry at condensed phase interfaces. Specific areas of research include the use of surface plasmon resonance (SPR) to monitor biopolymer adsorption, the chemical modification of surfaces with self-assembled monolayers for the creation of adsorption-based biosensors, the characterization of molecular monolayers at metal surfaces by polarization-modulation FTIR reflection absorption spectroscopy (PM-FTIRRAS) and optical second harmonic generation (SHG) measurements of molecular orientation, the surface modification of gold nanoparticles, and the synthesis of magnetic nanoparticles for high frequency inductor applications. Prof. Corn also has ongoing research projects in the implementation of DNA computing algorithms at surfaces, and the fabrication of multilayer polyelectrolyte films for ion transport applications. | |
| Publications | Iuliana E. Sendroiu, Megan E. Warner, and Robert M. Corn, "Fabrication of silica-coated gold nanorods functionalized with DNA for enhanced SPR imaging biosensing applications," Langmuir, 25 11282-11284 (2009). | |
| Aaron R. Halpern, Naoya Nishi, Jia Wen, Fan Yang, Chengxiang Xiang, Reginald Penner, and Robert M. Corn, "Characterization of Electrodeposited Gold and Palladium Nanowire Gratings with Optical Diffraction Measurements," Analytical Chem., 81 5585-5592 (2009). | ||
| Yulin Chen, Anh Nguyen, Lifang Niu and Robert M. Corn, "Fabrication of DNA Microarrays with poly-L-Glutamic Acid Monolayers on Gold Substrates for SPR Imaging Measurements," Langmuir, 25 5054-5060 (2009). | ||
| Jorge A. Lamboy, Phillip Y. Tam, Lucie S. Lee, Pilgrim J. Jackson, Sara K. Avrantinis, Hye Jin Lee, Robert M. Corn and Gregory A. Weiss, "Chemical and Genetic Wrappers for Improved Phage and RNA Display," ChemBioChem, 9 2846-2852 (2008). | ||
| Matthew R. Lockett, Stephen C. Weibel, Margaret F. Phillips, Michael R. Shortreed, Bin Sun, Robert M. Corn, Robert J. Hamers, Franco Cerrina, and Lloyd M. Smith, "Carbon-on-Metal Films for Surface Plasmon Resonance Detection of DNA Arrays," J. Am. Chem. Soc., 130 8611-8613 (2008). | ||
| Iuliana Sendroiu and Robert M. Corn, "Nanoparticle diffraction gratings for DNA detection on photopatterned glass substrates," Biointerphases, 3 FD23-FD29 (2008). | ||
| Hye Jin Lee, Alastair Wark and Robert M. Corn, "Microarray methods for protein biomarker detection," Analyst, 133 975-983 (2008). | ||
| Hye Jin Lee, Alastair Wark and Robert M. Corn, "Enhanced bioaffinity sensing using surface plasmons, surface enzyme reactions, nanoparticles and diffraction gratings," Analyst, 133 596-601 (2008). | ||
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Alastair Wark, Hye Jin Lee and Robert M. Corn,"Multiplexed Detection Methods for Profiling microRNA Expression in Biological Samples," Angewandte Chemie, 47 644-652 (2008). |
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Yuan Li, Hye Jin Lee, and Robert M. Corn, "Detection of Protein Biomarkers using RNA Aptamer Microarrays and Enzymatically Amplified SPR Imaging," Analytical Chem., 79 1082-1088 (2007). |
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Alastair Wark, Abraham Qavi, Hye Jin Lee, and Robert M. Corn, "Nanoparticle-Enhanced Diffraction Gratings for Ultrasensitive Surface Plasmon Biosensing," Analytical Chem., 79 6697 - 6701 (2007). |
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Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Ultra-Sensitive Microarray Detection of DNA using Enzymatically Amplified SPR Imaging," in New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis, Nancy Xu, ed., Wiley-Interscience, 2007, ISBN: 978-0-471-74660-7 pp. 169-194. |
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Hye Jin Lee, Alastair Wark and Robert M. Corn, "Utilizing ultrathin DNA/poly-lysine multilayer films to create liquid/liquid interfaces: spectroscopic characterization, interfacial reactions and nanoparticle adsorption," J. Physics: Condensed Matter 19 Article No. 375107 (2007). |
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R. Zadoyan, H. Ye. Seferyan, A. W. Wark, R. M. Corn, and V. A. Apkarian, "Interfacial Velocity-Dependent Plasmon Damping in Colloidal Metallic Nanoparticles," J. Phys. Chem. C, 111 10836-10840 (2007). |
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| Shiping Fang, Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Attomole Detection of microRNAs by Nanoparticle-Amplified SPR Imaging Measurements of Surface Polyadenylation Reactions," J. Am. Chem. Soc., 128 14044-14046 (2006). | ||
| Yuan Li, Hye Jin Lee, and Robert M. Corn, "Fabrication and characterization of RNA aptamer microarrays for the study of protein-aptamer interactions with SPR imaging," Nucleic Acids Research, 34 6416-6424 (2006). | ||
| Hye Jin Lee, Dobrin Nedelkov and Robert M. Corn, "SPR Imaging Measurements of Antibody Arrays for the Multiplexed Detection of Low Molecular Weight Protein Biomarkers," Analytical Chem., 78 6504-6510 (2006). | ||
| Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Creating Advanced Multifunctional Biosensors with Surface Enzymatic Transformations," Langmuir, 22 5241-5250 (2006). | ||
| Yuan Li, Alastair W. Wark, Hye Jin Lee and Robert M. Corn, "Single Nucleotide Polymorphism Genotyping by Nanoparticle-Enhanced SPR Imaging Measurements of Surface Ligation Reactions," Analytical Chem., 78 3158-3164 (2006). | ||
| Hye Jin Lee, Alastair W. Wark, Yuan Li and Robert M. Corn, "Fabricating RNA Microarrays with RNA-DNA Surface Ligation Chemistry," Analytical Chem., 77 7832-7837 (2005). | ||
| Shiping Fang, Hye Jin Lee, Alastair W. Wark, Hyun Min Kim and Robert M. Corn, "Determination of Ribonuclease H Surface Enzyme Kinetics by Surface Plasmon Resonance Imaging and Surface Plasmon Fluorescence Spectroscopy," Analytical Chem., 77 6528-6534 (2005). | ||
| Hye Jin Lee, Yuan Li, Alastair W. Wark and Robert M. Corn, "Enzymatically Amplified SPR Imaging Detection of DNA by Exonuclease III Digestion of DNA Microarrays," Analytical Chem., 77 5096-5100 (2005). | ||
| Alastair W. Wark, Hye Jin Lee, and Robert M. Corn, "Long-Range Surface Plasmon Resonance Imaging for Bioaffinity Sensors," Analytical Chem., 77 3904-3907 (2005). | ||
| Hye Jin Lee, Alastair W. Wark, Terry T. Goodrich, Shiping Fang and Robert M. Corn, "Surface Enzyme Kinetics for Biopolymer Microarrays: A Combination of Langmuir and Michaelis-Menten Concepts," Langmuir, 21 4050 - 4057 (2005). | ||
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Professional Societies |
Sigma Xi American Chemical Society Society for Applied Spectroscopy International Society of Electrochemistry AAAS |
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| Other Experience |
Professor University of Wisconsin 1985—2004 |
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Joined UCI Faculty in 2004 |
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| Graduate Programs |
Chemistry Biomedical Engineering |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5123 | |
| Last updated | 10/10/2009 | |