Z. David Luo

Professor, Anesthesiology
School of Medicine

Joint Appointment, Pharmacology
School of Medicine

Professor, Reeve-Irvine Research Center (RIRC)

Ph.D., State University of New York at Buffalo, 1993, Biochemical Pharmacology


M.D., China, 1984, Medicine

Phone: (949) 824-7469
Fax: (949) 824-7447
Email: zluo@uci.edu

University of California, Irvine
Department of Anesthesiology
837 Health Sci. Rd., Gillespie Bldg., Rm. 3113
Mail Code: 4265
Irvine, CA 92697

picture of Z. David  Luo

Research
Interests
Molecular Mechanisms of Chronic Pain
   
URLs Anestheisology Home page
   
Pharmacology Home Page
   
Pharmacology lab page
   
See below for selected publications or click here for additional publication listings available via PUB MED
   
Academic
Distinctions
1997-1999 NIH postdoctoral fellow, UC San Diego.

2005 NIH National Institute of Neurological Disorders and Stroke IRG (NSD-C Study Section).

2005 NIH Molecular, Cellular and Developmental Neurosciences IRG Study Section.

2007, 2008 NIH National Institute of Neurological Disorders and Stroke Special Emphasis Panel.

2009-2014 NIH National Institute of Dental and Craniofacial Research Special Review Committees.

2010 Department of Veterans Administration Special Emphasis Panel/Rehabilitation Research and Development Scientific Review Groups

2010-2014 Department of Defense Congressionally Directed Medical Research Programs Review Committees

2014 Chair, Department of Defense Congressionally Directed Medical Research Program Review Committee
   
Research
Abstract
My research interests focus on understanding the molecular mechanisms of neuropathic pain and cancer pain processing. Gene chip microarray and hypothesis-driven studies utilizing techniques of molecular and cell biology, immunohistochemistry and behavioral pharmacology are performed to study gene expression regulation and its contributions to pain transduction in experimental animal models.
   
Publications Luo, Z. D., Chaplan, S. R., Scott, B. P., Cizkova, D., Calcutt, N. A. and Yaksh, T. L. Neuronal nitric oxide synthase mRNA up-regulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. (1999) J. Neurosci., 19 (21) 9201-9208.

Luo, Z. D. Molecular dissection of pain mediators (2000). Pain Reviews. 7 (1), 37-64.

Luo, Z.D. Rat dorsal root ganglia express distinctive forms of the a2 calcium channel subunit (2000) NeuroReport 11 (16), 3449-3452.

Luo, Z.D. and Cizkova, D. The role of nitric oxide in nociception (2000) In: Current Review of Pain. Vol. 4 (6), 459-466. Eds. G.M. Aronoff, M.A. Giamberardino, O. de Leon-Casasola, R. P. Pawl, P. P. Rai, J. E. Heavner and H. Bosscher. Current Science Inc., Philadelphia.

Luo, Z.D., Chaplan, S.R., Higuera, E.S., Sorkin, L.S., Stauderman, K.A., Williams, M.E., and Yaksh, T.L. Up-regulation of dorsal root ganglion a2d calcium channel subunit and its correlation with allodynia in spinal nerve injured rats. (2001) J. Neurosci. 21(6), 1868-1875.

Yaksh, T.L., Dirig, D.M., Conway, C.M., Svensson, C., Luo, Z.D. and Isakson, P.C. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2), but not COX-1. (2001) J. Neurosci. 21 (16), 5847-5853.

Luo, Z.D., Calcutt, N.A., Higuera, E.S., Valder, C.R., Svensson, C.I. and Myers, R.R. Injury type-specific calcium channel a2d-1 subunit upregulation in rat neuropathic pain models correlates with anti-allodynic effects of gabapentin. (2002) J. Pharmacol. Exp. Ther. 303 (3), 1199-1205.

Schafers, M., Geis, C., Luo, Z.D., and Sommer, C. Selective increase of tumor necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve (2003) Eur. J. Neurosci. 17, 791-804.

Valder, C.R., Liu, J-J., Song, Y-H., and Luo, Z.D. Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development. (2003) J. Neurochem. 87, 560-573.

Luo, Z.D. (Volume Editor) Pain Research: Methods and Protocols (2004). In: Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99. The Humana Press Inc., Totowa, NJ.

Luo, Z.D. Mechanistic dissection of pain: from DNA to animal models (2004) In: Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 1-10. The Humana Press Inc., Totowa, NJ.

Higuera, E. S. and Luo, Z. D. A rat pain model of vincristine-induced neuropathy (2004). In Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 91-98. The Humana Press Inc., Totowa, NJ.

Luo, Z.D. and Berman, H.A. Pb++-mediated down-regulation of dihydropyridine receptors in skeletal muscle (2004) Toxic. Lett., 152, 167-173.

Li, C-Y, Song, Y-H, Higuera, E. S., and Luo, Z.D. Spinal dorsal horn calcium channel alpha-2-delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. (2004) J. Neurosci. 24, 8494-8499.

Luo, Z.D. (Volume Editor) Pain Research: Methods and Protocols (2004). In: Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99. The Humana Press Inc., Totowa, NJ.

Luo, Z.D. Mechanistic dissection of pain: from DNA to animal models (2004) In: Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 1-10. The Humana Press Inc., Totowa, NJ.

Higuera, E. S. and Luo, Z. D. A rat pain model of vincristine-induced neuropathy (2004). In Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 91-98. The Humana Press Inc., Totowa, NJ.

Yaksh, T. L. and Luo, Z. D. Anatomy of the pain processing system (2006) In Interventional Pain Management Ed. S. D. Waldman. 3rd Ed. Elsevier, Philadelphia, PA.

Li, C-Y, Zhang, X-L, Matthews, E. A., Li, K-W., Kurwa, A., Gold, M., Dickenson, A. H., Feng, G. and Luo, Z.D. Calcium Channel ???1 Subunit Mediates Spinal Hyperexcitability in Pain Modulation. (2006) Pain 125, 20-34.

Hu, W-P., Zhang, C., Li, J-D., Luo, Z.D., Amadesi, S., Bunnett, N., and Zhou, Q-Y. Impaired pain sensation in mice lacking prokineticin 2. (2006) Mol. Pain, 2:35, 1-9.

Maneuf, Y.M., Luo, Z.D., and Lee, K. alpha-2-delta and mechanism of action of gabapentin in the treatment of pain. (2006) Semi. Cell Dev. Biol. 17:565-570.

Xiao, W., Boroujerdi, A., Bennett, G.J., and Luo, Z.D. Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. (2007) Neuroscience, 144:714-720.

Luo, Z.D., Figueroa, K.W. Multiple genomic approach in pain research: basic science and clinical implications. (2008) Reviews in Analgesia 10:45-58.

Svensson, CI, Medicherla, S, Malkmus, S., Jiang, Y., Ma, JY, Kerr, I, Brainin-Mattos, J, Powell, HC, Luo, Z.D, Chakravarty, S, Dugar, S, Higgins, LS, Protter, AA, and Yaksh, TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. (2008) Pharmacology, Biochemistry and Behavior 90:664-675.

Boroujerdi, A., Kim, H-K., Lyu, Y-S., Kim, D-S., Figueroa, K.W., Chung, J.M., Luo, Z.D. Injury discharges induce calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to neuropathic pain initiation. (2008) Pain 139:358-366.

Nguyen, D., Deng, P., Matthews, E.A., Kim, D-S., Dickenson, A-H., Xu, Z.C., and Luo, Z.D. Enhanced pre-synaptic glutamate release in deep-dorsal horn regulates calcium channel alpha-2-dalta-1 protein-medicated spinal sensitization and behavioral hypersensitivity. (2009) Mol. Pain 5:6, 1-13.

Kim, D-S., Figueroa, K.W., Yolo, T., Boroujerdi, A., and Luo, Z.D. Characterization of dynamically changed gene expression during neuropathic pain development: injury-induced glial fibrillary acetic protein in dorsal root ganglia contributes to maintenance of neuropathic pain. (2009) Pain 143:114-122.

Perret, D. and Luo, Z.D. Targeting voltage-gated calcium channels for neuropathic pain management. (2009) Neurotherapeutics 6:679-692

Eroglu C, Allen N.J., Susman, M.W., O’Rourke, N.A., Park, C.Y., Ozkan, E., Charkraborty, C., Mulinyawe, S.B., Annis, D.S., Huberman A, Green, E.M., Lawler, J., Dolmetsch, R., Garcia, K.C., Smith, Luo Z.D., Rosenthal, A., Lawler, J., Mosher D.F., and Barres B.A. The calcium channel a2d1 is the neuronal thrombospondin receptor responsible for synaptogenesis. (2009) Cell 139:380-392.

Lu, S-G., Zhang, X-L., Luo, Z.D., Gold, M.S. Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat DRG neurons. (2010) Pain 151:633-643. PMID: 20884119.

Park, J.F., and Luo, Z.D. Calcium Channel Functions in Pain Processing. (2011) Channels, 4:510-517. PMID: 21150297.

Boroujerdi, A, Zeng, J, Sharp, K, Kim, J, Steward, O, Luo, Z.D. Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury induced neuropathic pain states. (2011) Pain, 152:649-655. PMID: 21239111.

Perret, D.M., Kim, D-S., Sinavsky, K., Miller, J.M., Luo, Z.D. Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents modulates nerve injury-induced tactile allodynia. (2011) Anesthesia & Analgesia, 113:610-616. PMID: 21596869.

Kim, D-S., Li, K-W., Boroujerdi, A., Yu, Y. P., Zhou, C., Deng, P., Park, J., Zhang, X., Lee, J., Corpe, M., Sharp, K., Steward, O., Eroglu, C., Barres, B., Zaucke, F., Xu, Z.C., and Luo, Z.D. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain. (2012) J. Neurosci., 32, 8977-8987. PMID: 22745497, PMCID: PMC3408211.

Hata, J., Perret-Karimi, P., DeSilva, C., Leung, D., Betesh, N., Luo, Z.D., Dawodu, S., Sinavsky, K., Stokes, J., and English, S. Pulsed radiofrequency current in the treatment of pain. (2012) Critical Reviews in Physical and Rehabilitation Medicine, 23, 213-240

Chang, E. Y., Chen, X., Sandhu, A., Li, C-Y, Luo, Z.D. Spinal 5-HT3 receptors facilitate behavioral hypersensitivity induced by elevated calcium channel alpha-2-deltal-1 protein. (2013) Eur. J. Pain, 17, 505-513, PMID: 23065867, PMCID: PMC3548964

Zeng, J., Kim, D., Li, K-W., Sharp, K., Steward, O., Zaucke, F., and Luo, Z.D. Thrombospondin-4 contributes to spinal cord injury induced changes in nociception. (2013) Eur. J. Pain, 17, 1458-1464. PMID: 23649982, PMCID: PMC3762950

Li, K-W, Kim, D-S., Zaucke, F., and Luo, Z.D. Trigeminal nerve injury induced thrombospondin-4 upregulation contributes to orofacial neuropathic pain states in a rat model. (2013) Eur. J. Pain, 18, 489-495. PMID: 24019258, PMCID: PMC3947726

Zhou, C., and Luo, Z.D. Electrophysiological characterization of dorsal horn neuron sensitization by elevated calcium channel alpha-2-delta-1 subunit protein. (2013) Eur. J. Pain, 18, 649-658. PMID: 24151064, PMCID: PMC3989413

Zhang, Y., Wang, C., Wang, L., Parks, G.S., Zhang, X., Guo, Z., Ke, Y., Li, K-W., Kim, M.K., Vo, B., Borrelli, E., Yang, L., Ge, G., Yang, L., Wang, Z., Garcia-Fuster, M. J., Luo, Z.D., Liang, X., Civelli, O. A novel analgesic isolated from a traditional Chinese medicine. (2014) Current Biology, 24, 117-123.PMID: 24388848, PMCID: PMC3912990

Chang, E., Zhao, X., Perret, D.M., Luo, Z. D., and Liao, S.S. A comprehensive, multi-specialty approach to an acute exacerbation of chronic central pain in a tetraplegic. (2014) Spinal Cord, 52 Suppl. 1:S17-18 PMID: 24513720

Li, K-W, Yu, Y.P., Zhou, C., Kim, D-S, Lin, B., Sharp, K., Steward, O., and Luo, Z. D. Calcium channel a2d1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. (2014) J. Biol. Chem., 289, 7025-7037. PMID: 24459143, PMCID: PMC3945363

Chang, E.Y., Chen, X., Kim, M., Gong, N., Bhatia, S., and Luo, Z. D. Differential effects of voltage-gated calcium channel blockers on calcium channel alpha-2-delta-1 subunit protein mediated nociception. (2015) Eur. J. Pain, 19, 639-648. PMID: 25158907, PMCID: 4344437.

Pan, B., Yu, H., Park, J., Yu, Y.P., Luo, Z.D., Hogan, Q.H. Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia. (2015) J. Neurosci. Res., 93, 443-453. PMID: 25327416, PMCID: 4293337

Crosby, N., Zaucke, F., Kras, J.V., Dong, L., Luo, Z.D., Winkelstein, B.A. Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury. (2015) Exp. Neurol. 264, 111-120. PMID: 25483397, PMCID: 4324021

Zhou, C., and Luo, Z.D. Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia. (2015) Eur. J. Pain, in press. PMID: 25691360
   
Grants Pharmaceutical Research and Manufacturers of America Foundation (PhRMA) PRMAF-52427, 01/01/12-12/31/13, $40,000 direct costs, Molecular dissection of thrombospondin-4 domains in pain processing (Role: Sponsor for predoctoral student, John Park).
   
National Institute of Nursing Research (NINR) R21 NR013756, 07/01/12-06/30/14, $275,000 direct costs, Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief (Role: P.I.).
   
Roman Reed Grant (California Spinal Cord Injury Research Funds) Award #RR2012-11, 2012-2013, $99,811 direct costs, Thrombospondin-4 and calcium channel alpha-2-delta-1 protein interactions in mediating spinal cord injury pain (Role: P.I.).
   
National Institute of Child Health and Human Development (NICHD) K12 HD001097, 2011-2014, $314,750 total costs, Rehabilitation medicine scientist training program (Role: Sponsor for K12 research fellow Eric Chang).
   
National Institute of Neurological Disorders and Storke (NINDS) R01 NS064341, 02/01/10-01/31/16, $847,354 direct costs, Mechanism of calcium channel Cava2d1 protein mediated neuropathic pain (Role: P.I.).
   
National Institute of Dental and Craniofacial Research (NIDCR) R01 DE021847, 04/07/11-02/29/16, $2,539,829 direct costs, A novel pathway mediating the development of chronic orofacial neuropathic pain (Role: P.I.).
   
National Institute of Dental and Craniofacial Research (NIDCR) R01 DE021847-03S1, 04/07/13-02/29/16, $246,646 direct costs, A novel pathway mediating the development of chronic orofacial neuropathic pain (Role: P.I.).
   
Professional
Societies
American Society for Pharmacology and Experimental Therapeutics
American Pain Society
International Association for the Study of Pain
Society for Neuroscience
American Association for the Advancement of Science
   
Graduate Programs Pharmacological Sciences

Interdepartmental Neuroscience Program

Medicinal Chemistry and Pharmacology

   
Research Center Chao Family Comprehensive Cancer Center, UCI
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5077
   
Last updated 05/31/2015