Taosheng HuangAssociate Professor, Developmental & Cell Biology Associate Professor, Pediatrics |
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Research Interests |
Molecular basis of genetic diseases in humans | |
| URL | www.ucihs.uci.edu/com/pediatrics/drhuang/ | |
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Academic Distinctions |
1989 American Society of Virology Travel Fellowship 1990 Third Place, SCBA Poster Competition 1996 Resident Research Award, Georgetown University Hospital 1996 National Health Institute Fellowship Training Grant 1999-2004 Clinical Associate Physician Award |
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Research Abstract |
The primary interests of Huang Lab are in the molecular basis of genetic diseases in humans. Currently, the Lab is focusing on Holt-Oram syndrome (HOS, Heart-Hand syndrome), an autosomal dominant condition with congenital cardiac defects and forelimb anomalies. This condition is caused by mutation of TBX5. We are employing clinical and basic research approaches to understand the intracellular pathway of TBX5, molecular basis of phenotypic variations and its gene regulation | |
| Publications | Mike Zaragoza, Guifeng Sun, Christopher Price, JG Seidman, Christine E Seidman Taosheng Huang: Mutation Analysis of TBX5 in Families with Holt-Oram Syndrome: Novel Mutations, Polymorphism and the Absence of TBX5 Mutations in preparation | |
| Weiwei Fan, Xu Huang, Chira Chen, Joe Gray and Taosheng Huang: TBX3 and TBX3+2a are Functionally Distinctive in Inhibition of Senescence and are Overexpressed in a Subset of Breast Cancer Cell Lines, Submitted | ||
| Mike Zaragoza, Lisa E. Lewis, Guifeng Sun, Eric Wang, Ling Li, Ilham Said-Salman, Laura Feucht, Taosheng Huang: Identification of the TBX5 Transactivating Domain And the Nuclear Localization Signal, Gene, in press | ||
| Guifeng Sun Lisa E Lewis, Xu Huang, Quang Nguyen, Christopher Price, Taosheng Huang: Tbx5, A Gene Mutated In Holt-Oram Syndrome, Is Regulated through a GC-Box and TBEs, Journal of Cellular Biochemistry, in press 2003 | ||
| Drapkin RI, Genest DR, Holmes LB, Huang T, Vargas SO. Unilateral transverse arm defect with subterminal digital nubbins. Pediatrics Developmental Pathology 6(4): 348-354, 2003. | ||
| Helen M. Lyon, Lewis B Holmes and Taosheng Huang Multiple congenital anomalies associated with in utero exposure phynotoin support hypoxic ischemic mechanisms Birth Defect Research (Part A) 67:993-996, 2003 | ||
| Taosheng Huang, James E Lock, Audrey C Marshall, Craig Basson, J.G. Seidman, Christine E. Seidman. Causes of Clinical Diversity in TBX5 Mutations Cold Spring Harbor Quantitative Biology Symposium, LXVII 115-120, 2003 | ||
| Taosheng Huang & Mark Korson, Celeste Krauss, Lewis B. Holmes: A New Genetic Syndrome: Four Cases with Encephalocele, triphalangeal thumb, American Journal of Medical Genetics 111:178-181, 2002 (Collected by London Dysmorphology Database) | ||
| Taosheng Huang, Angela E. Lin, Gerry Cox, Wendy L. Golden, Mitsuhiro Kamisago, Gerald L. Feldman, Stefan Vermeulen, Moog Ute, Connie Schrander-Stumpel: Variable Cardiac Phenotypes in Chromosome 4q- Syndrome with dHAND Deletion, Genetics in Medicine, 4(6) 464-467, 2002 | ||
| Taosheng Huang, Wenxue Yang, Alexandre Pereira, Vivian E Shih. Cloning and characterization of a putative human 2-hydroxylacid dehydrogenase, Biophysica Biochemica Research Communication, 268:298-301. 2000 | ||
| Craig T Basson, Taosheng Huang, Robert Lin, David R Bachinsky, Stanislawa Weremowicz, Alicia Vaglio, Rina Bruzzone, Roberto Quadrelli, Margherita Lerone, Giovanni Romeo, Margherita Silengo, Cynthia C Morton, Christoph W Muller, JG Seidman, Christine E Seidman, Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome. Proceedings of the National Academy Sciences of the USA, 96:2919-2924, 1999 | ||
| Taosheng Huang, Ellen Elias, John B Mulliken, Daniel J Kirse and Lewis B Holmes. A new syndrome: cardiac defects, Laryngeal anomalies, preaxial polydactyly, and colonic aganglionosis in sibs. Genetics in Medicine, 1(3):104-108, 1999 (Collected by Possum Database and OMIN) | ||
| Huang T, Pavloic J, Staeheli P, and Krystal M. Overexpression of the influenza polymerase protein can titrate out inhibition by the murine Mx1 protein. Journal of Virology 66:4154-4160. 1992 | ||
| Park KH, Huang T, Correia FF, and Krystal M. Rescue of a foreign gene by Sendai virus. Proceeding of the National Academy Sciences of USA 88:5537-5541. 1991 | ||
| Huang T, and Hsu MT. Inhibition of DNA replication of adenovirus type 5 and Simian virus 40 by tunicamycin. Virology 182:889-893. 1991 | ||
| Huang T, Palese P, and Krystal M. Determination of influenza virus proteins required for genome replication. Journal of Virology 64:5669-5673. 1990 | ||
| Chu Y, Huang T, and Hsu MT. P1 nuclease defines a subpopulation of active SV40 chromatin-- a new nuclease hypersensitivity assay. Nucleic Acid Research 18:3705-3711. 1989 | ||
| Huang T, and Dong, Y. Assay of the protein turnover rate for skeletal muscle. Biochem Biophys Acta 11:43-48. 1987 | ||
| Huang T, and Dong, Y. Changes in protein and nucleic acid metabolism in the liver of the scalded rats. Acta Academia Medicine 10:41-45. 1987 | ||
| Huang T, and Dong Y. Changes in protein metabolism in the soleus muscle of the scalded rats and therapeutic effect of leucine and insulin (II). Journal of PLA Medical Colleges 4:1-9. 1987 | ||
| Huang T, and Dong Y. Changes in protein metabolism in the soleus muscle of the scalded rats and therapeutic effect of leucine and insulin (II). Journal of PLA Medical Colleges 4:1-9. 1987 | ||
| Grants | University of California Cancer Research Coordinating Committee Molecular studies of TBX3 in Human Breast cancer | |
| Clinical Associate Physician Award Title: The Molecular Basis of Phenotypic Variability in Holt-Oram Syndrome The major goals of this project are to isolate and characterize the promoter of TBX5, genotype-phenotype correlation and to provide insight into the understanding of the structure-function relationship of TBX5. | ||
| College of Medicine, UCI research award Howard Hughes Medical Research Program | ||
| 2003-2004 Faculty Desktop Computing Initiative Allocation College of Medicine, UCI | ||
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Professional Societies |
Fellow, American College of Medical Genetics, 2003- Western Society for Pediatric Research 2001- American Society of Human Genetics American Association for Advancement of Science American Academy of Pediatrics Medical Director & Board Director American Chinese Medical Association (ACMA) 1998-2001 Vice President of ACMA, New England Area, 1998-2000 |
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| Other Experience |
Attending Physician and Assistant in Medicine Children's Hospital, Harvard Medical School 1999—2001 |
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Instructor in Genetics Children's Hospital, Harvard Medical School 1999—2001 |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5072 | |
| Last updated | 03/04/2009 | |