Clinical Professor, Medicine
School of Medicine

Thrombotic Thrombocytopenic Purpura(TTP), Coagulopathy and Thrombophilia, and Neoplastic Fever

Distinguished Teacher's Award (1978-1979), Good Samaritan Hospital, Dayton, Ohio
Professional Excellence Award for Education, Research and Service, Academy of Medicine (1985), Wright State University School of Medicine, Dayton, Ohio
Faculty Teacher of the Year Award (1984-1985), Wright State University School of Medicine
Medical Essay Competition Award (1990) for Medical Economics
Laureate Award, American College of Physicians, American Society of Internal Medicine (2001), Ohio Chapter
Special Commendation for Professional Achievement in Teaching, Research and Service (2002), Ohio Senate Assembly
Recognition for Distinguished Service as Teaching Faculty (2003), Wright State University School of Medicine, Dayton, Ohio
Physician of Excellence Honoree (2007), Orange County Medical Society

Mainly Dr. Chang has conducted patient-oriented clinical research in "Thrombotic Microangiopathic Syndromes", especially in critical care settings. His particular interest has been Postoperative Thrombotic Thrombocytopenic Purpura (TTP) and unrecognized clinical syndromes associated with TTP, such as Acute respiratory Distress Syndrome (ARDS) and Peripheral Digit Ischemic Syndrome (PDIS). Additionally, he has studied the different types of Thrombotic Microangiopathic Syndromes and their relationship to ADAMTS 13 activity. Neoplastic Fever is another area of interest, particulary the use of "Naproxen Test".

Ikhlaque N, and Chang JC: Thrombotic Microangiopathy Presenting as Fulminating Rhabdomyolysis with Multiorgan Dysfunction. Hospital Physician 2003;39(6):51-56

Chang JC: Why do We Still Use the Term FUO in our Profession? (Editorial Correspondence) Arch Intern Med 2003;163:2102

Chang JC, and Naqvi T: Thrombotic Thrombocytopenic Purpura Associated with Bone Marrow Metastasis and Secondary Myelofibrosis in Cancer. Oncologist 2003;8(4):375-380

Kathula SK, Koduri J, Mall S, and Chang JC: A Case Report of Total Abdominal Hysterectomy Resulting in Acute Thrombotic Thrombocytopenic Purpura with Pancreatitis and Hepatitis: Complete Resolution with Plasma Exchange. Therap Apher Dial. 2003;7(3):373-374

Chang JC: The Understanding of Thrombotic Thrombocytopenic Purpura: Dyadic, Triadic, Pentadic and Other Manifestations. J Clin Apheresis 2004;19(1):2-4

Naqvi TA, Baumann MA, and Chang JC: Postoperative Thrombotic Thrombocytopenic Purpura: A Review. Inter J of Clinical Practice 2004;58(2):169-172

Chang JC, and Newman RS: Redefining the Syndromes of Thrombotic Microangiopathy (Invited Editorial). Ther Apheresis Dial 2004;8(2):73-74

Chang JC, and Ikhlaque N: Peripheral Digit Ischemic Syndrome as a Serious Manifestation of Postoperative Thrombotic Thrombocytopenic Purpura. Ther Apheresis Dial 2004;8(5):413-418

Zell JA., Yoon EJ., Ou SH I., Hoefs JC, and Chang JC: Precore Mutant Hepatitis B Reactivation after Treatment with CHOP-Rituximab. Anti-Cancer Drugs 2005;16(1):83-85

Zell JA, and Chang JC: Neoplastic Fever: A Neglected Paraneoplastic Syndrome. Supportive Care Cancer. 2005;13(11):870-877

Saltzman DJ, Chang JC, Newman RS, Jimenez JC, Carson JG, Abolhoda A, Milliken JC. Postoperative thrombotic thrombocytopenic purpura following open heart surgery. Annals of Thoracic Surgery. 2010; 89(1):119-123

Southwest Oncology Group

American Society of Clinical Oncologists

American Society of Hematology

American College of Physicians

Chao Family Comprehensive Cancer Center

Link to this profile
https://faculty.uci.edu/profile/?facultyId=4996

Last updated
04/16/2010