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Steven L Wechsler

Professor, Ophthalmology
School of Medicine

Professor, Microbiology & Molecular Genetics
School of Medicine

Professor, Center for Virus Research

Ph.D., University of North Carolina, Chapel Hill, NC, 1975, Molecular Genetics

Phone: (949) 824-9490
Fax: (949) 824-9626
Email: wechsler@uci.edu

University of California, Irvine
Gavin Herbert Eye Institute
843 Health Sciences Rd.
Rm. 2012
Mail Code: 4390
Irvine, CA 92697

picture of Steven L Wechsler

   
  1. Wechsler, S.L. and Fields, B.N. (1978). Differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. Nature. 272:458-60.

2. Wechsler, S.L. and Fields, B.N. (1978). Intracellular synthesis of measles virus-specified polypeptides. J Virol. 25:285-97.

3. Wechsler, S.L., Weiner, H.L. and Fields, B.N. (1979). Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. J Immunol. 123:884-9.

4. Wechsler, S.L., Rustigian, R., Stallcup, K.C., Byers, K.B., Winston, S.H. and Fields, B.N. (1979). Measles virus-specified polypeptide synthesis in two persistently infected HeLa cell lines. J Virol. 31:677-684. PMCID: PMC353496

5. Stallcup, K.C., Wechsler, S.L. and Fields, B.N. (1979). Purification of measles virus and characterization of subviral components. J Virol. 30:166-76.

6. Wechsler, S.L., Weyand, S., Goosmann, A. and Burge, B.W. (1982). The protease inhibitor TLCK alters the apparent molecular weights of some measles virus proteins by a mechanism unrelated to inhibition of proteolytic cleavage. Virology. 121:204-8.

7. Wechsler, S.L. and Meissner, H.C. (1983). Elevated antibody levels against measles virus P protein in sera of patients with multiple sclerosis. Infect Immun. 40:1226-9.

8. Frank, E.H., Burge, B.W., Liwnicz, B.H., Lotspeich, L.J., White, J.C., Wechsler, S.L., Mayfield, F.H. and Keller, J.T. (1983). Cytokeratin provides a specific marker for human arachnoid cells grown in vitro. Exp Cell Res. 146:371-6.

9. Wechsler, S.L., Lambert, D.M., Galinski, M.S., Heineke, B.E. and Pons, M.W. (1985). Human parainfluenza virus 3: purification and characterization of subviral components, viral proteins and viral RNA. Virus Res. 3:339-51.

10. Wechsler, S.L., Lambert, D.M., Galinski, M.S. and Pons, M.W. (1985). Intracellular synthesis of human parainfluenza type 3 virus-specified polypeptides. J Virol. 54:661-4.

11. Young, K.K., Heineke, B.E. and Wechsler, S.L. (1985). M protein instability and lack of H protein processing associated with nonproductive persistent infection of HeLa cells by measles virus. Virology. 143:536-45.

12. Wechsler, S.L., Lambert, D.M., Galinski, M.S., Heineke, B.E., Lambert, A.L., Mink, M., Rochovansky, O.M. and Pons, M.W. (1985). A simple method for increased recovery of purified paramyxovirus virions. J Virol Methods. 12:179-82.

13. Galinski, M.S., Mink, M.A., Lambert, D.M., Wechsler, S.L. and Pons, M.W. (1986). Molecular cloning and sequence analysis of the human parainfluenza 3 virus RNA encoding the nucleocapsid protein. Virology. 149:139-51.

14. Galinski, M.S., Mink, M.A., Lambert, D.M., Wechsler, S.L. and Pons, M.W. (1986). Molecular cloning and sequence analysis of the human parainfluenza 3 virus mRNA encoding the P and C proteins. Virology. 155:46-60.

15. Galinski, M.S., Mink, M.A., Lambert, D.M., Wechsler, S.L. and Pons, M.W. (1987). Molecular cloning and sequence analysis of the human parainfluenza 3 virus gene encoding the matrix protein. Virology. 157:24-30.

16. Wechsler, S.L., Lambert, D.M., Galinski, M.S., Mink, M.A., Rochovansky, O. and Pons, M.W. (1987). Immediate persistent infection by human parainfluenza virus 3: unique fusion properties of the persistently infected cells. J Gen Virol. 68:1737-48.

17. Rock, D.L., Nesburn, A.B., Ghiasi, H., Ong, J., Lewis, T.L., Lokensgard, J.R. and Wechsler, S.L. (1987). Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J Virol. 61:3820-6.

18. Wechsler, S.L., Nesburn, A.B., Watson, R., Slanina, S.M. and Ghiasi, H. (1988). Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J Virol. 62:4051-8.

19. Wechsler, S.L., Nesburn, A.B., Watson, R., Slanina, S. and Ghiasi, H. (1988). Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans. J Gen Virol. 69:3101-6.

20. Wechsler, S.L., Nesburn, A.B., Zwaagstra, J. and Ghiasi, H. (1989). Sequence of the latency-related gene of herpes simplex virus type 1. Virology. 168:168-72.

21. Zwaagstra, J., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1989). In vitro promoter activity associated with the latency-associated transcript gene of herpes simplex virus type 1. J Gen Virol. 70:2163-9.

22. Nesburn, A.B., Ghiasi, H. and Wechsler, S.L. (1990). Ocular safety and efficacy of an HSV-1 gD vaccine during primary and latent infection. Invest Ophthalmol Vis Sci. 31:1497-502.

23. Zwaagstra, J.C., Ghiasi, H., Slanina, S.M., Nesburn, A.B., Wheatley, S.C., Lillycrop, K., Wood, J., Latchman, D.S., Patel, K. and Wechsler, S.L. (1990). Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol. 64:5019-28.

24. Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1991). Cell surface expression of herpes simplex virus type 1 glycoprotein H in recombinant baculovirus-infected cells. Virology. 185:187-94.

25. Ghiasi, H., Nesburn, A.B., Kaiwar, R. and Wechsler, S.L. (1991). Immunoselection of recombinant baculoviruses expressing high levels of biologically active herpes simplex virus type 1 glycoprotein D. Arch Virol. 121:163-78.

26. Zwaagstra, J.C., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1991). Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1). Virology. 182:287-97.

27. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1992). Baculovirus expressed herpes simplex virus type 1 glycoprotein C protects mice from lethal HSV-1 infection. Antiviral Res. 18:291-302.

28. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1992). Expression of herpes simplex virus type 1 glycoprotein B in insect cells. Initial analysis of its biochemical and immunological properties. Virus Res. 22:25-39.

29. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1992). Baculovirus-expressed glycoprotein H of herpes simplex virus type 1 (HSV-1) induces neutralizing antibody and delayed type hypersensitivity responses, but does not protect immunized mice against lethal HSV-1 challenge. J Gen Virol. 73:719-22.

30. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1992). Baculovirus-expressed glycoprotein G of herpes simplex virus type 1 partially protects vaccinated mice against lethal HSV-1 challenge. Virology. 190:233-9.

31. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1992). Expression of herpes simplex virus type 1 glycoprotein I in baculovirus: preliminary biochemical characterization and protection studies. J Virol. 66:2505-9.

32. Ghiasi, H., Kaiwar, R., Nesburn, A.B., Slanina, S. and Wechsler, S.L. (1992). Baculovirus-expressed glycoprotein E (gE) of herpes simplex virus type- 1 (HSV-1) protects mice against lethal intraperitoneal and lethal ocular HSV-1 challenge. Virology. 188:469-76.

33. Ghiasi, H., Slanina, S., Nesburn, A.B. and Wechsler, S.L. (1994). Characterization of baculovirus-expressed herpes simplex virus type 1 glycoprotein K. J Virol. 68:2347-54.

34. Ghiasi, H., Kaiwar, R., Nesburn, A.B., Slanina, S. and Wechsler, S.L. (1994). Expression of seven herpes simplex virus type 1 glycoproteins (gB, gC, gD, gE, gG, gH, and gI): comparative protection against lethal challenge in mice. J Virol. 68:2118-26.

35. Ghiasi, H., Kaiwar, R., Slanina, S., Nesburn, A.B. and Wechsler, S.L. (1994). Expression and characterization of baculovirus expressed herpes simplex virus type 1 glycoprotein L. Arch Virol. 138:199-212.

36. Nesburn, A.B., Burke, R.L., Ghiasi, H., Slanina, S., Bahri, S. and Wechsler, S.L. (1994). Vaccine therapy for ocular herpes simplex virus (HSV) infection: periocular vaccination reduces spontaneous ocular HSV type 1 shedding in latently infected rabbits. J Virol. 68:5084-92.

37. Perng, G.C., Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1994). An improved method for cloning portions of the repeat regions of herpes simplex virus type 1. J Virol Methods. 46:111-6.

38. Perng, G.C., Dunkel, E.C., Geary, P.A., Slanina, S.M., Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1994). The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol. 68:8045-55.

39. Perng, G.C., Zwaagstra, J.C., Ghiasi, H., Kaiwar, R., Brown, D.J., Nesburn, A.B. and Wechsler, S.L. (1994). Similarities in regulation of the HSV-1 LAT promoter in corneal and neuronal cells. Invest Ophthalmol Vis Sci. 35:2981-9.

40. Ghiasi, H., Cai, S., Slanina, S., Nesburn, A.B. and Wechsler, S.L. (1995). Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge. Antiviral Res. 28:147-57.

41. Ghiasi, H., Wechsler, S.L., Kaiwar, R., Nesburn, A.B. and Hofman, F.M. (1995). Local expression of tumor necrosis factor alpha and interleukin-2 correlates with protection against corneal scarring after ocular challenge of vaccinated mice with herpes simplex virus type 1. J Virol. 69:334-40.

42. Ghiasi, H., Bahri, S., Nesburn, A.B. and Wechsler, S.L. (1995). Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins. Invest Ophthalmol Vis Sci. 36:1352-60.

43. Perng, G.C., Thompson, R.L., Sawtell, N.M., Taylor, W.E., Slanina, S.M., Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L. (1995). An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. J Virol. 69:3033-41.

44. Perng, G.C., Slanina, S.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1996). A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J Virol. 70:2014-8.

45. Perng, G.C., Ghiasi, H., Slanina, S.M., Nesburn, A.B. and Wechsler, S.L. (1996). The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3- kilobase primary transcript. J Virol. 70:976-84.

46. Perng, G.C., Ghiasi, H., Slanina, S.M., Nesburn, A.B. and Wechsler, S.L. (1996). High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. J Virol. 70:2883-93.

47. Perng, G.C., Chokephaibulkit, K., Thompson, R.L., Sawtell, N.M., Slanina, S.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1996). The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J Virol. 70:282-91.

48. Ghiasi, H., Cai, S., Nesburn, A.B. and Wechsler, S.L. (1996). Vaccination with herpes simplex virus type 1 glycoprotein K impairs clearance of virus from the trigeminal ganglia resulting in chronic infection. Virology. 224:330-3.

49. Ghiasi, H., Perng, G.C., Cai, S., Nesburn, A.B. and Wechsler, S.L. (1996). The UL3 open reading frame of herpes simplex virus type 1 codes for a phosphoprotein. Virus Res. 44:137-42.

50. Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1996). Vaccination with a cocktail of seven recombinantly expressed HSV-1 glycoproteins protects against ocular HSV-1 challenge more efficiently than vaccination with any individual glycoprotein. Vaccine. 14:107-12.

51. Ghiasi, H., Cai, S., Nesburn, A.B. and Wechsler, S.L. (1997). MHC-II but not MHC-I responses are required for vaccine-induced protection against ocular challenge with HSV-1. Curr Eye Res. 16:1152-8.

52. Ghiasi, H., Cai, S., Slanina, S., Nesburn, A.B. and Wechsler, S.L. (1997). Nonneutralizing antibody against the glycoprotein K of herpes simplex virus type-1 exacerbates herpes simplex virus type-1-induced corneal scarring in various virus-mouse strain combinations. Invest Ophthalmol Vis Sci. 38:1213-21.

53. Ghiasi, H., Roopenian, D.C., Slanina, S., Cai, S., Nesburn, A.B. and Wechsler, S.L. (1997). The importance of MHC-I and MHC-II responses in vaccine efficacy against lethal herpes simplex virus type 1 challenge. Immunology. 91:430-5.

54. Nesburn, A.B., Burke, R.L., Ghiasi, H., Slanina, S.M. and Wechsler, S.L. (1998). Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus-specific tear secretory immunoglobulin A than systemic vaccination and provides protection against recurrent spontaneous ocular shedding of virus in latently infected rabbits. Virology. 252:200-9.

55. Nesburn, A.B., Slanina, S., Burke, R.L., Ghiasi, H., Bahri, S. and Wechsler, S.L. (1998). Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. J Virol. 72:7715-7721. PMCID: PMC110076

56. Nesburn, A.B., Burke, R.L., Ghiasi, H., Slanina, S.M. and Wechsler, S.L. (1998). A therapeutic vaccine that reduces recurrent herpes simplex virus type 1 corneal disease. Invest Ophthalmol Vis Sci. 39:1163-70.

57. Drolet, B.S., Perng, G.C., Cohen, J., Slanina, S.M., Yukht, A., Nesburn, A.B. and Wechsler, S.L. (1998). The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein. Virology. 242:221-32.

58. Carr, D.J., Halford, W.P., Veress, L.A., Noisakran, S., Perng, G.C. and Wechsler, S.L. (1998). The persistent elevated cytokine mRNA levels in trigeminal ganglia of mice latently infected with HSV-1 are not due to the presence of latency associated transcript (LAT) RNAs. Virus Res. 54:1-8.

59. Ghiasi, H., Nesburn, A.B., Cai, S. and Wechsler, S.L. (1998). The US5 open reading frame of herpes simplex virus type 1 does encode a glycoprotein (gJ). Intervirology. 41:91-7.

60. Ghiasi, H., Wechsler, S.L., Cai, S., Nesburn, A.B. and Hofman, F.M. (1998). The role of neutralizing antibody and T-helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV-1 challenge. Immunology. 95:352-9.

61. Ghiasi, H., Cai, S., Perng, G., Nesburn, A.B. and Wechsler, S.L. (1999). Perforin pathway is essential for protection of mice against lethal ocular HSV-1 challenge but not corneal scarring. Virus Res. 65:97-101.

62. Ghiasi, H., Hofman, F.M., Cai, S., Perng, G.C., Nesburn, A.B. and Wechsler, S.L. (1999). Vaccination with different HSV-1 glycoproteins induces different patterns of ocular cytokine responses following HSV-1 challenge of vaccinated mice. Vaccine. 17:2576-82.

63. Ghiasi, H., Pemg, G.C., Hofman, F.M., Cai, S., Nesburn, A.B. and Wechsler, S.L. (1999). Specific and nonspecific immune stimulation of MHC-II-deficient mice results in chronic HSV-1 infection of the trigeminal ganglia following ocular challenge. Virology. 258:208-16.

64. Loutsch, J.M., Perng, G.C., Hill, J.M., Zheng, X., Marquart, M.E., Block, T.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1999). Identical 371-base-pair deletion mutations in the LAT genes of herpes simplex virus type 1 McKrae and 17syn+ result in different in vivo reactivation phenotypes. J Virol. 73:767-771. PMCID: PMC103886

65. Perng, G.C., Slanina, S.M., Yukht, A., Drolet, B.S., Keleher, W., Jr., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1999). A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation. J Virol. 73:920-929. PMCID: PMC103911

66. Perng, G.C., Slanina, S.M., Yukht, A., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (1999). Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses. J Virol. 73:9669-9672. PMCID: PMC113008

67. Ghiasi, H., Perng, G., Nesburn, A.B. and Wechsler, S.L. (1999). Either a CD4(+)or CD8(+)T cell function is sufficient for clearance of infectious virus from trigeminal ganglia and establishment of herpes simplex virus type 1 latency in mice. Microb Pathog. 27:387-94.

68. Ghiasi, H., Cai, S., Slanina, S.M., Perng, G.C., Nesburn, A.B. and Wechsler, S.L. (1999). The role of interleukin (IL)-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease. J Infect Dis. 179:1086-93.

69. Drolet, B.S., Perng, G.C., Villosis, R.J., Slanina, S.M., Nesburn, A.B. and Wechsler, S.L. (1999). Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency-associated transcript (LAT) partially restores wild-type spontaneous reactivation to a LAT-null mutant. Virology. 253:96-106.

70. Perng, G.C., Slanina, S.M., Yukht, A., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (2000). The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits. J Virol. 74:1885-1891. PMCID: PMC111666

71. Perng, G.C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., Slanina, S.M., Hofman, F.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. (2000). Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript. Science. 287:1500-1503.

72. Ghiasi, H., Cai, S., Perng, G.C., Nesburn, A.B. and Wechsler, S.L. (2000). Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Br J Ophthalmol. 84:408-12.

73. Ghiasi, H., Cai, S., Perng, G.C., Nesburn, A.B. and Wechsler, S.L. (2000). The role of natural killer cells in protection of mice against death and corneal scarring following ocular HSV-1 infection. Antiviral Res. 45:33-45.

74. Ghiasi, H., Perng, G., Nesburn, A.B. and Wechsler, S.L. (2000). Antibody-dependent enhancement of HSV-1 infection by anti-gK sera. Virus Res. 68:137-44.

75. Inman, M., Perng, G.C., Henderson,G., Ghiasi. H., Nesburn, A.B., Wechsler, S.L., and Jones, C. (2001) Region of herpes simplex virus type 1 latency associated transcript sufficient for wild type spontaneous reactivation promotes cell survival in tissue culture. J.Virol. 75:3636-3646. PMCID: PMC114855.

76. Perng, GC, Slanina, SM, Ghiasi, H, Nesburn, AB, Wechsler, S.L. (2001) The effect of LAT (latency associated transcript) on the herpes simplex virus type 1 (HSV 1) latency-reactivation phenotype is mouse strain dependent. J.g.Virol. 82:1117-1122.

77. Samoto, K., Perng, GC, Ehtesham, M, Liu, Y, Wechsler, S.L., Nesburn, AB, Black, KL, and Yu, JS (2001) A herpes simplex virus type 1 mutant deleted for ?34.5 and LAT kills glioma cells in vitro and is inhibited for in vivo reactivation. Cancer Gene Therapy. 8:269-277.

78. Perng, GC, Esmaili, D., Slanina, SM., Yukht, A., Ghiasi, H., Osorio, N., Mott, KR., Maguen, B., Jin, L., Nesburn, AB., and Wechsler, SL. (2001). Three HSV 1 LAT mutants with distinct asymmetric effects on virulence in mice compared to rabbits. J.Virol. 75:9018-9028. PMCID: PMC114470

79. Ghiasi H, Hofman FM, Wallner K, Cai S, Perng GC, Nesburn AB, and Wechsler, S.L. (2001). Corneal macrophage infiltrates following ocular herpes simplex virus type 1 challenge vary in BALB/c mice vaccinated with different vaccines. Vaccine 19:1266-73.

80. Ghiasi H, Osorio Y, Perng GC, Nesburn AB, and Wechsler SL. (2001). Recombinant Herpes Simplex Virus Type 1 Expressing Murine Interleukin-4 Is Less Virulent than Wild-Type Virus in Mice. J Virol 75:9029-9036. PMCID: PMC114471

81. Samoto K, Ehtesham M, Perng GC, Hashizume K, Wechsler SL, Nesburn AB, Black KL, and Yu JS. (2002). A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery 50:599-605.

82. Perng GC, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, and Wechsler SL. (2002). A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol 76:1224-1235. PMCID: PMC135864

83. BenMohamed L., Wechsler SL, and Nesburn AB. (2002) Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infect Dis 2:425-31.

84. Ghiasi H, Osorio Y, Hedvat Y, Perng GC, Nesburn AB, and Wechsler SL. (2002) Infection of BALB/c mice with a herpes simplex virus type 1 recombinant virus expressing IFN-gamma driven by the LAT promoter. Virology 302:144-54.

85. Ghiasi H, OsorioY, Nesburn AB, and Wechsler SL. (2002) Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2. Virology 302:286-93.

86. Ghiasi H, Osorio Y, Perng GC, Nesburn AB, and Wechsler SL. (2002) Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity. J Virol 76:9069-9078. PMCID: PMC136420

87. Henderson G, Peng W, Jin L, Perng GC, Nesburn AB, Wechsler SL, and Jones C. (2002) Suppression of caspase 8 and caspase 9 induced apoptosis by the herpes simplex virus (HSV-1) encoded latency associated transcript (LAT). J Neurovirol 8:103-111.

88. Moxley MJ, Block TM, Liu HC, Fraser NW, Perng GC, Wechsler SL, and Su YH. (2002). Herpes simplex virus type 1 infection prevents detachment of nerve growth factor-differentiated PC 12 cells in culture. J. gen. Virol. 83:1591-1600.

89. Osorio Y, Wechsler SL, Nesburn AB, and Ghiasi H. (2002) Reduced severity of HSV-1-induced corneal scarring in IL-12-deficient mice. Virus Res 90:317-26.

90. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J, Benmohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, and Wechsler SL. (2002). A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. J.Virol. 76:8003-8010. PMCID: PMC155148

91. Perng GC, Mott KR, Osorio N, Yukht A, Salina S, Nguyen QH, Nesburn AB, and Wechsler SL (2002) Herpes simplex virus type 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non-McKrae-like virulence. J Gen Virol 83:2933-42.

92. Jin L, Peng W, Perng GC, Brick DJ, Nesburn AB, Jones C, and Wechsler SL (2003) Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype. J. Virol. 11:6556-6561. PMCID: PMC155006

93. BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL, and Nesburn AB (2003) Identification of Novel Immunodominant CD4+ Th1-Type T-Cell Peptide Epitopes from Herpes Simplex Virus Glycoprotein D That Confer Protective Immunity J. Virol. 77: 9463-9473. PMCID: PMC187395

94. Mott KR, Osorio N, Jin L, Brick D, Naito J, Cooper J, Henderson G, Inman M, Jones C, Wechsler SL, and Perng, GC (2003) The BHV-1 LR ORF-2 is critical for this gene's ability to restore the high wild type reactivation phenotype to an HSV-1 LAT null mutant. J. gen. Virol. 84: 2975-85.

95. Peng W, Henderson G, Perng GC, Nesburn AB, Wechsler SL, and Jones C (2003) The gene that encodes the herpes simplex virus type 1 latency associated transcript promotes the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins. J. Virol. 77: 10714-10718. PMCID: PMC228484

96. Henderson G, Perng GC, Nesburn AB, Wechsler SL, and Jones C (2004) The latency related (LR) gene encoded by bovine herpesvirus 1 (BHV-1) can suppress caspase 3 and caspase 9 cleavage during productive infection. J Neurovirology. 10:64-70.

97. Jin L, Perng GC, Brick DJ, Naito J, Nesburn AB, Jones C, and Wechsler SL (2004) Methods for detecting the HSV-1 LAT anti-apoptosis activity in virus infected tissue culture cells. J.Virol.Methods. 118: 9-13.

98. Peng W, Jin L, Henderson G, Perng GC, Brick DJ, Nesburn AB, Wechsler SL, and Jones C (2004) Mapping herpes simplex virus type 1 latency associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8. J. NeuroVirol. 10:260-265.

99. Drolet BS, Mott KR, Lippa AM, Wechsler SL, and Perng GC. (2004) Glycoprotein C of herpes simplex virus type 1 Is required to cause keratitis at low infectious doses In intact rabbit corneas. Current Eye Res. 29:181-189.

100. Barsam CA, Brick DJ, Jones C, Wechsler SL, and Perng GC (2005) A viral model for corneal scarring and neovascularization following ocular infection of rabbits with a HSV-1 mutant. Cornea. 24:460-466.

101. Peng W, Henderson G, Inman M, BenMohamed L, Perng GC, Wechsler SL, and Jones C. (2005) The locus encompassing the latency associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal ganglia of acutely infected mice. J. Virol. 79:6162-6171. PMCID: PMC1091686

102. Jin L, Perng GC, Mott KR, Osorio N, Naito J, Brick DJ, Carpenter D, Jones C, and Wechsler SL (2005) A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene (cpIAP) in place of LAT (Latency Associated Transcript) has a wild type reactivation phenotype in the mouse. J. Virol. 79:12286-12295. PMCID: PMC1211541

103. Chan D, Cohen J, Naito J, Mott KR, Osorio N, Jin L, Fraser NW, Jones C, Wechsler SL, and Perng GC. (2006) A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits. J. Neurovirol. 12:5-16.

104. Morishige N, Naito J, Osorio N, Wahlert A, Jones C, Everett RD, Jester JV, Wechsler SL, and Perng GC (2006) HSV-1 ICP0 localizes in the stromal layer of infected rabbit corneas and predominantly resides in the cytoplasm and or perinuclear region of rabbit keratocytes. J.gen.Virology 87:2817-25.

105. Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL, and BenMohamed L. 2006. Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system. Ocul Surf 4:178-87.

106. Solbrig MV, Adrian R, Wechsler SL, and Koob GF (2007) Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. Eur J Pharmacol. 555:23-29.

107. Jin L, Perng GC, Carpenter D, Mott KR, Osorio N, Naito J, Brick DJ, Jones C, and Wechsler SL (2007) Reactivation Phenotype in Rabbits of a Herpes Simplex Virus Type 1 (HSV-1) Mutant Containing an Unrelated Anti-Apoptosis Gene in Place of LAT. J. Neurovirol. 13:78-84. PMID: 17454452.

108. Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, and BenMohamed L (2007) Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. J Virol 81:7647-61. PMCID: PMC1933381

109. Bettahi I, Nesburn AB, Yoon S, Mohebbi A, Suey V, Vanderberg A, Wechsler SL, and BenMohamed L (2007) Protective Immunity Against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines. Invest. Ophthalmol. Vis. Sci. 48:4643-4653.

110. Carpenter D, Hsiang C, Brown DJ, Jin L, Osorio N, Benmohamed L, Jones C, and Wechsler SL (2007) Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology. 369:12-18. PMID: 17727910. PMCID: PMC2276668

111. Carpenter D, Henderson G, Hsiang C, Osorio N, BenMohamed L, Jones C, and Wechsler SL (2008) Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity. Microbial Pathogenesis 44:98-102. PMID: 17727910. PMCID: PMC2291025

112. Peng W, Vitvitskaia O, Carpenter D, Wechsler SL, Jones C (2008) Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1 (HSV-1) encoded latency-associated transcript (LAT). J. Neurovirol. 14:41-52. PMID: 18300074.

113. Chentoufi AA, Zhang X; Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, and BenMohamed L (2008) Human Leukocyte Antigen (HLA)-A*0201-Restricted CD8+ Cytotoxic T-Lymphocyte Epitopes Identified from Herpes Simplex Virus Glycoprotein D. J.Immunol. 180:426-437. PMID: 18097044.

114. Jin L, Carpenter D, Moerdyk-Schauwecker M, Vanarsdall AL, Osorio N, Hsiang C, Jones C and Wechsler SL (2008) Cellular FLIP can substitute for the herpes simplex virus type 1 LAT gene to support a wild type virus reactivation phenotype in mice. J. Neurovirol. 14:389-400. PMID: 18989818

115. Carpenter D, Singh S, Osorio N, Hsiang C, Jiang X, Jin L, Jones C, and Wechsler SL (2008) Mutation of a putative ribozyme site in the herpes simplex virus type 1 gene that encodes LAT does not decrease the viral reactivation phenotype. J.Neurovirol. Nov 3:1-5. PMID: 18982533

116. Mott KR, Underhill D, Wechsler SL and Ghiasi H (2008) Lymphoid-related CD11c+ CD8?+ dendritic cells are involved in enhancing Herpes simplex Virus type 1 latency. J Virol 82:9870-9879. PMCID: PMC2566288

117. Dasgupta G, Chentoufi AA, Nesburn AB, Wechsler SL, BenMohamed L (2009) New concepts in herpes simplex virus vaccine development: notes from the battlefield. Expert Rev Vaccines 8(8):1023-1035. PMCID: PMC2760836

118. Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L. (2009) A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunol. 2:129-143. PMID: 19129756

119. Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H (2009) A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol J. 6:56. PMCID: PMC2686698.

120. Mott KR, Chentoufi AA, Carpenter D, Benmohamed L, Wechsler SL, Ghiasi H (2009) The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity. Invest Ophthalmol Vis Sci. 50:2903-2912. PMID: 19439086

121. Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL, Ghiasi H. (2009) Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice. J Virol. 83:2246-2254. PMCID: PMC2643740

122. Henderson G, Jaber T, Carpenter D, Wechsler SL, and Jones C. (2009) Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript. J Neurovirol 15:439-48.

123. Jaber T, Henderson G, Li S, Perng GC, Carpenter D, Wechsler SL, Jones C. (2009) Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency. J Gen Virol. 90:2342-2352. PMCID: PMC2888094.

124. Dasgupta G, Nesburn AB, Wechsler SL, and BenMohamed L. (2010) Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiol 5:1-4.

125. Li S, Carpenter D, Hsiang C, Wechsler SL, and Jones C. (2010) Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels. J Gen Virol 91:858-66.

126. Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB, Wechsler SL, and BenMohamed L (2010). A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes. J Immunol 184:2561-71. PMID: 20124097

127. Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, and BenMohamed L (2010). Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol 17:342-53. PMCID: PMC2837957.

128. Mott KR, Wechsler SL, Ghiasi H. (2010) Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo. Mol Vis. 26:2153-2162. PMCID: PMC2994333

129. Jiang X, Chentoufi AA, Hsiang C, Carpenter D, Osorio N, Benmohamed L, Fraser NW, Jones C, and Wechsler SL (2011) The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing. J Virol 85:2325-32. PMCID: PMC3067767

130. Allen S, Hamrah JP, Gate DM, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GF, Sharpe AH, Benmohamed L, Ahmed R, Wechsler SL, and H. Ghiasi. (2011) The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Virol. 85:4184-4197. PMCID: PMC3126262

131. Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L. (2011) The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J Virol. 85:9127-9138. PMCID: PMC3165846

132. Allen SJ, Mott KR, Chentoufi AA, Benmohamed L, Wechsler SL, Ballantyne CM, Ghiasi H. (2011) CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection. J Virol. 85:9945-9955.

133. Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H. (2011) Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation. J Virol. 85:11448-11456.

135. Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, Jiang X, Nesburn AB, Wechsler SL, Benmohamed L. (2012) The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells. Viral Immunol. 25:204-215. PMID: 22512280

136. Dervillez X, Gottimukkala C, Kabbara KW, Nguyen C, Badakhshan T, Kim SM, Nesburn AB, Wechsler SL, Benmohamed L. (2012) Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine. Future Virol. 2012 7:371-378. PMID: 22701511.

137. Watson G, Xu W, Reed A, Babra B, Putman T, Wick E, Wechsler SL, Rohrmann GF, Jin L. (2012) Sequence and comparative analysis of the genome of HSV-1 strain McKrae. Virology. 433:528-537. PMID:23021301
   
Grant Corneal HSV-1: LAT’s Anti-Apoptosis Activity and Latency. NIH—R01EY013191. $2,436,580. 6-1-09 to 5-31-14. Role: Principal Investigator
   
   
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Last updated 06/14/2013