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Robert A Edwards

Associate Professor, Clinical X, Pathology
School of Medicine

Ph.D., Baylor College of Medicine, 1995, Cell Biology


M.D., Baylor College of Medicine, 1997

Phone: 949-824-8576
Fax: 949-824-2160
Email: redwards@uci.edu

University of California, Irvine
D449, Med Sci I
Irvine, CA 92697


Research
Interests
Colitis and Colon Cancer, Tumor Microenvironment, Metabolic Imaging, Translational Research
   
Research
Abstract
Patents:
Monoclonal anti-thioredoxin antibodies, Baylor College of Medicine Technologies, and Invitrogen Corp., Office of Technology Transfer Agreement #OTA-95-13
   
Publications Bryan, J., Edwards, R.A., Matsudaira, P., Otto, J., and Wulfkuhle, J. Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product. Proc. Natl. Acad. Sci. U S A 90:9115-9119, 1993.
   
  Edwards R.A., Herrera-Sosa, H., Otto, J., and Bryan, J. Cloning and expression of a murine fascin homolog from mouse brain. J. Biol. Chem. 270:10764-70, 1993.
   
  Edwards, R.A., Bryan, J. Fascins, a family of actin bundling proteins. Cell Motil. Cytoskeleton
32:1-9, 1995.
   
  Dickason, R.R., Edwards, R.A., Bryan, J., and Huston, D.P. Versatile E. coli thioredoxin specific monoclonal antibodies afford convenient analysis and purification of prokaryote expressed soluble fusion protein. J. Immunol. Methods 185:237-44, 1995.
   
  Tao, Y.S., Edwards, R.A., Tubb, B., Wang, S., Bryan, J., and McCrea, P.D. Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex. J. Cell Biol. 134:1271-81, 1996.
   
  Smith, V.C., Edwards, R.A., Jorgensen, J.L., Goldfarb, R.A., Kadmon, D., Cagle, P. C., and Truong, L.D. Unilocular retroperitoneal cyst of mesothelial origin presenting as a renal mass. Arch. Pathol. Lab Med. 124: 766-9, 2000.
   
  Zhao, B., Chua, S.S., Burcin, M.M., Edwards, R.A., Finegold, M.J., Tsai, S.Y., and DeMayo, F.J. Phenotypic consequences of lung-specific inducible expression of FGF-3. Proc. Natl. Acad. Sci. U S A 98(10): 5898-5903, 2001.
   
  Zhang, Y, Schlossman S.F., Edwards R.A., Ou C.N., Gu J., and Wu M.X..
Impaired Apoptosis, Extended Effector-Phase of Immune Responses, and Autoimmunity in IEX-1-Transgenic Mice. Proc. Natl. Acad. Sci. U S A, 99: 878-883, 2002.
   
  Ahlering,T.E., Woo, D., Eichel, L., Lee, D. I., Edwards, R. A., and Skarecky, D.W.. Robot-Assisted vs. Open Radical Prostatectomy: A comparison of one surgeon’s outcomes. Urology, 63(5):819-22, 2004
   
  Ahlering, T.E., Eichel, L., Edwards, R.A., Lee, D., and Skarecky, D.W. Robotic Radical Prostatectomy: A technique to reduce pT2 Positive Margins. Urology, 64(6):1224-8, 2004.
   
  Wu, J.Y., Zhang, Y., Edwards, R.A., Finegold, M.J., Jin, Y., Wu, M.X. Impairment of TGF-beta signaling in T cells of Gai2-/- mice. J. Immunol. 174 (10): 6122-6128, 2005.
   
  Ahlering, T.E., Eichel, L., Edwards, R.A., and Skarecky, D.W. The Impact of Obesity on Clinical Outcomes in Robotic Prostatectomy. Urology 65(4): 740-744, 2005.
   
  Edwards, R.A., and Smock, A.Z. Defective arachidonate release and PGE2 production in Gi?2-Deficient Intestinal and Colonic Subepithelial Myofibroblasts. Inflammatory Bowel Diseases 12 (3):153-165, 2006.
   
  Stiles, L.N., Hosking, M.P., Edwards, R.A., Strieter, R.M., and Lane, T. E., Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. Eur J.
Immunol. 36(3):613-22, 2006.
   
  Hoang, B., Trinh, A., and Edwards, R. A. Decreased MAPK- and PGE2-dependent IL-11 production in Gia2-/- colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007 Mar 1; [Epub ahead of print].
   
  Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E.TNF-a Induces Up-Regulation of EGFR Expression and Signaling in Human Colonic Myofibroblasts.Am J Physiol Gastrointest Liver Physiol. 2012 Feb 2.
   
  Walsh K.B., Edwards, R.A., Romero, K.M., Kotlajich, M.V., Stohlman, S.A., and Lane, T.E.. Expression of CXCL10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease. J. Immunol 179(2):1155-65, 2007.
   
  Kim I.Y., Eichel L., Edwards R.A., Uribe C., Chou D.S., Abdelshehid C., Ahlering M, White S, Woo E., McDougall, E., and Clayman, R.V.. Effects of commonly used hemostatic agents on the porcine collecting system. Journal of Endourology. June 1, 2007, 21(6): 652-654.
   
  Walsh K.B., Lodoen M.B., Edwards R.A., Lanier L.L., Lane T.E.. Evidence for differential roles for NKG2D signaling in innate host defense against coronavirus-induced neurological and liver disease. J. Virol., 82: 3021-3030, 2008.
   
  Borin JF, Deane LA, Sala LG, Abdelshehid CS, White SM, Poulson AK, Khan F, Edwards
RA, McDougall EM, Clayman RV.Comparison of healing after cystotomy and repair
with fibrin glue and sutured closure in the porcine model. J Endourol. 2008 Jan;22(1):145-50.
   
  Edwards, R.A., Wang, K., Davis, J.S., Birnbaumer, L.. A role for epithelial dysregulation in
early onset colitis- associated colon cancer in Gi2-alpha-/- mice. Inflammatory Bowel
Diseases 2008 Jul;14(7):898-907
   
  Tirotta, E., Fontaine, V., Picetti, R., Lombardi, M., Samad, T.A., Oulad-Abdelghani, M.,
Edwards, R.A., and Borrelli, E. Signaling by dopamine regulates D2 receptors
trafficking at the membrane. Cell Cycle, 2008 Jul; 14:2241-8.
   
  Chen, P-C., Kuraguchi, M., Velasquez, J., Wang, Y, Yang, K., Edwards, R.A., Gillen, D.,
Edelmann, W., Kucherlapati, R., Lipkin, S.M.. Novel Roles for MLH3 Deficiency and
TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression. PLoS Genet 2008 Jun 13;4(6):e1000092
   
  Shukla D, Box GN, Edwards RA, Tyson DR. Bone marrow stem cells for urologic tissue
engineering. World J Urol. 2008 Aug; 26(4): 341-9.
   
  Box GN, Lee HJ, Abraham JB, Deane LA, Elchico ER, Abdelshehid CA, Alipanah R, Taylor
MB, Andrade L, Edwards RA, Borin JF, McDougall EM, Clayman RV.. Comparative study of in vivo lymphatic sealing capability of the porcine thoracic duct using laparoscopic dissection devices. J Urol. 2009 Jan;181(1):387-91. Epub 2008 Nov 17.
   
  Krebs A, Deane LA, Borin JF, Edwards RA, Sala LG, Khan F, Abdelshehid C, McDougall
EM, Clayman RV. The 'buoy' stent: evaluation of a prototype indwelling ureteric stent in
a porcine model. BJU Int. 2009 Jul;104(1):88-92
   
  Box GN, Lee HJ, Abraham JB, Deane LA, Santos RJ, Elchico ER, Khosravi A, Abdelshehid
CA, Alipanah R, Li K, Moskowitz RM, Philips JM, Edwards RA, Borin JF, McDougall
EM, Clayman RV. Evaluation of the outcomes of electrosurgical induced bowel injury treated with tissue glue/sealant versus sutured repair in a rabbit model. J Endourol. 2009 Mar;23(3):535-40.
   
  Edwards, R.A., Witherspoon, M., Wang, K., Afrasiabi, K., Pham, T. Birnbaumer, L., and Lipkin, S.M. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Research 2009 Aug 15; 69(16):6423-9. Epub Jul 28, 2009.
   
  Najdi, R., A. Syed, L. Arce, H. Theisen, J.T. Ting, F. Atcha, A.V. Nguyen, M. Martinez, R.F. Holcombe, R.A. Edwards, J.L. Marsh, M.L. Waterman. A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene, 2009 Nov 26, 28(47):4133-46.
   
  Zhao, F., Edwards, R.A, Dizon, D., Mastroianni, J.R., Geyfman, M., Ouellette., A.J., Andersen, B., and S. M. Lipkin. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Developmental Biology, 2010 Feb 15;338(2):270-9. Epub 2009 Dec 16.. PMID: 20025862
   
  Sikandar, S.S, Pate, K.T., Anderson, S., Dizon, D, Edwards, R.A., Waterman, M.L., and Lipkin, S.M. NOTCH signaling is required for colon cancer initiating cell tumor formation, self-renewal and repression of secretory cell lineage differentiation. Cancer Research 2010 Feb 15, 70(4): 1469-78. PMID: 20145124
   
  Louie MK, Gamboa AJ, Kaplan AG, Khosravi A, Truong H, Andrade L, Lin R, Alipanah R, Ortiz C, McCormick D, Box GN, Lee HJ, Deane LA, Edwards RA, McDougall EM, Clayman RV. Bovine serum albumin glutaraldehyde for completely sutureless laparoscopic heminephrectomy in a survival porcine model. J Endourol. 2010 Mar;24(3):451-5
   
  Chen, Y., Chen, C.-F., Chiang, H.-C., Pena, M., Polci, R., Wei, R., Edwards, R.A., Hansel, D.E., Chen, P.-L., and Riley, D.J. Mutation of NIMA-related kinase 1 (Nek1) leads to chromosome instability. Molecular Cancer 2011, 10:5.
   
  Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a. Cell Metab. 2011 May 4;13(5):540-9.
   
  Galitovskiy, V., Chernyavskyy, O., Marchenko,S., Qian, J., Edwards, R.A., Gindi, V., Grando, S.. Cytokine-Induced Alterations of a7 Nicotinic Receptor in Colonic CD4+ T-cells Mediate Dichotomous Response to Nicotine in Murine Models of Th1/Th17 vs. Th2-mediated Colitis. J. Immunol, Epub ahead of print, 22 July 2011.
   
  Liu, J.Z., Jellbauer, S., Poe, A., Pesciaroli, M., Kehl-Fie, T., Restrepo, N., Hosking, M., Edwards, R.A., Battistoni, A., Pasquali, P., Lane, T.L., Chazin, W., Vogl, T., Roth, J., Skaar, E., and Raffatellu, M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host & Microbe, 2012 March 15. Cell Host Microbe. 2012 Mar 15;11(3):227-39.
   
  Galitovskiy V., Chernyavsky A.I., Edwards R.A., Grando S.A. Muscle sarcomas and
alopecia in A/J mice chronically treated with nicotine. Life Sci. 2012 Apr 12. [Epub ahead of print]
   
  Chen, J., Edwards, R.A., Milsom, J., Lee, S., Shen, X., and S.M. Lipkin.
The Chemokine Receptor 9-Chemokine 25 Axis Suppresses Colon Cancer Invasion and Metastasis. J Clin Invest. 2012 Aug 6. pii: 62110. doi: 10.1172/JCI62110. [Epub ahead of print
   
  Jahid S., Sun J., Edwards R.A., Dizon D., Panarelli N.C., Milsom J.W., Sikandar S.S., Gümüs Z.H., Lipkin S.M. miR-23a Promotes the Transition from Indolent to Invasive Colorectal Cancer. Cancer Discov. 2012 May 25. [Epub ahead of print]
   
  Stringari, C., Edwards, R.A., Pate, K., Waterman, M., Donovan, P.J., and E.Gratton. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Scientific Reports (Nature), Sci Rep. 2012;2:568. Epub 2012 Aug 10.
   
  Grando et al.. The Tobacco Carcinogen Nitrosamine Induces a Differential Gene Expression Response in Tumor Susceptible A/J and Resistant C3H Mouse Lungs. European Journal of Cancer 2012 Sep 22. pii: S0959-8049(12)00689-2. doi: 10.1016/j.ejca.2012.08.027. [Epub ahead of print]
   
  Crosignani, V., Dvornikov, A., Aguilar, J.S., Stringari, C., Edwards, R.A., Mantulin, W.W., Gratton, E. Deep tissue fluorescence imaging and in vivo biological applications J. Biomed. Opt. 17 (11), 116023 (November 08, 2012)
   
  Nguyen HM, Galea CA, Schmunk G, Smith BJ, Edwards RA, Norton RS, Chandy KG . Intracellular trafficking of the KV1.3 potassium channel is regulated by the pro-domain of a matrix metalloprotease. J Biol Chem. 2013 Mar 1;288(9):6451-64.
   
  Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P.
Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9897-902.
   
  Deriu E, Liu JZ, Pezeshki M, Edwards RA, Ochoa RJ, Contreras H, Libby SJ, Fang FC, Raffatellu M. Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe. 2013 Jul 17;14(1):26-37.
PMID:23870311
   
Other Experience
Graduate Programs Pathology-Anatomic and Clinical

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4909
   
Last updated 08/05/2013