Robert A EdwardsAssistant Professor in Residence, Pathology |
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Research Interests |
Mucosal Immunology, Inflammatory Bowel Disease, Colon Cancer, MSI, Translational Research | |
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Research Abstract |
Patents: Monoclonal anti-thioredoxin antibodies, Baylor College of Medicine Technologies, and Invitrogen Corp., Office of Technology Transfer Agreement #OTA-95-13 |
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| Publications | Galitovskiy, V., Chernyavskyy, O., Marchenko,S., Qian, J., Edwards, R.A., Gindi, V., Grando, S.. Cytokine-Induced Alterations of a7 Nicotinic Receptor in Colonic CD4+ T-cells Mediate Dichotomous Response to Nicotine in Murine Models of Th1/Th17 vs. Th2-mediated Colitis. J. Immunol, Epub ahead of print, 22 July 2011. | |
| Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a. Cell Metab. 2011 May 4;13(5):540-9. | ||
| Chen, Y., Chen, C.-F., Chiang, H.-C., Pena, M., Polci, R., Wei, R., Edwards, R.A., Hansel, D.E., Chen, P.-L., and Riley, D.J. Mutation of NIMA-related kinase 1 (Nek1) leads to chromosome instability. Molecular Cancer 2011, 10:5. | ||
| Louie MK, Gamboa AJ, Kaplan AG, Khosravi A, Truong H, Andrade L, Lin R, Alipanah R, Ortiz C, McCormick D, Box GN, Lee HJ, Deane LA, Edwards RA, McDougall EM, Clayman RV. Bovine serum albumin glutaraldehyde for completely sutureless laparoscopic heminephrectomy in a survival porcine model. J Endourol. 2010 Mar;24(3):451-5 | ||
| Sikandar, S.S, Pate, K.T., Anderson, S., Dizon, D, Edwards, R.A., Waterman, M.L., and Lipkin, S.M. NOTCH signaling is required for colon cancer initiating cell tumor formation, self-renewal and repression of secretory cell lineage differentiation. Cancer Research 2010 Feb 15, 70(4): 1469-78. PMID: 20145124 | ||
| Zhao, F., Edwards, R.A, Dizon, D., Mastroianni, J.R., Geyfman, M., Ouellette., A.J., Andersen, B., and S. M. Lipkin. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Developmental Biology, 2010 Feb 15;338(2):270-9. Epub 2009 Dec 16.. PMID: 20025862 | ||
| Najdi, R., A. Syed, L. Arce, H. Theisen, J.T. Ting, F. Atcha, A.V. Nguyen, M. Martinez, R.F. Holcombe, R.A. Edwards, J.L. Marsh, M.L. Waterman. A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene, 2009 Nov 26, 28(47):4133-46. | ||
| Edwards, R.A., Witherspoon, M., Wang, K., Afrasiabi, K., Pham, T. Birnbaumer, L., and Lipkin, S.M. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Research 2009 Aug 15; 69(16):6423-9. Epub Jul 28, 2009. | ||
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Box GN, Lee HJ, Abraham JB, Deane LA, Santos RJ, Elchico ER, Khosravi A, Abdelshehid CA, Alipanah R, Li K, Moskowitz RM, Philips JM, Edwards RA, Borin JF, McDougall EM, Clayman RV. Evaluation of the outcomes of electrosurgical induced bowel injury treated with tissue glue/sealant versus sutured repair in a rabbit model. J Endourol. 2009 Mar;23(3):535-40. |
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Krebs A, Deane LA, Borin JF, Edwards RA, Sala LG, Khan F, Abdelshehid C, McDougall EM, Clayman RV. The 'buoy' stent: evaluation of a prototype indwelling ureteric stent in a porcine model. BJU Int. 2009 Jul;104(1):88-92 |
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Box GN, Lee HJ, Abraham JB, Deane LA, Elchico ER, Abdelshehid CA, Alipanah R, Taylor MB, Andrade L, Edwards RA, Borin JF, McDougall EM, Clayman RV.. Comparative study of in vivo lymphatic sealing capability of the porcine thoracic duct using laparoscopic dissection devices. J Urol. 2009 Jan;181(1):387-91. Epub 2008 Nov 17. |
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Shukla D, Box GN, Edwards RA, Tyson DR. Bone marrow stem cells for urologic tissue engineering. World J Urol. 2008 Aug; 26(4): 341-9. |
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Chen, P-C., Kuraguchi, M., Velasquez, J., Wang, Y, Yang, K., Edwards, R.A., Gillen, D., Edelmann, W., Kucherlapati, R., Lipkin, S.M.. Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression. PLoS Genet 2008 Jun 13;4(6):e1000092 |
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Tirotta, E., Fontaine, V., Picetti, R., Lombardi, M., Samad, T.A., Oulad-Abdelghani, M., Edwards, R.A., and Borrelli, E. Signaling by dopamine regulates D2 receptors trafficking at the membrane. Cell Cycle, 2008 Jul; 14:2241-8. |
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Edwards, R.A., Wang, K., Davis, J.S., Birnbaumer, L.. A role for epithelial dysregulation in early onset colitis- associated colon cancer in Gi2-alpha-/- mice. Inflammatory Bowel Diseases 2008 Jul;14(7):898-907 |
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Borin JF, Deane LA, Sala LG, Abdelshehid CS, White SM, Poulson AK, Khan F, Edwards RA, McDougall EM, Clayman RV.Comparison of healing after cystotomy and repair with fibrin glue and sutured closure in the porcine model. J Endourol. 2008 Jan;22(1):145-50. |
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| Walsh K.B., Lodoen M.B., Edwards R.A., Lanier L.L., Lane T.E.. Evidence for differential roles for NKG2D signaling in innate host defense against coronavirus-induced neurological and liver disease. J. Virol., 82: 3021-3030, 2008. | ||
| Kim I.Y., Eichel L., Edwards R.A., Uribe C., Chou D.S., Abdelshehid C., Ahlering M, White S, Woo E., McDougall, E., and Clayman, R.V.. Effects of commonly used hemostatic agents on the porcine collecting system. Journal of Endourology. June 1, 2007, 21(6): 652-654. | ||
| Walsh K.B., Edwards, R.A., Romero, K.M., Kotlajich, M.V., Stohlman, S.A., and Lane, T.E.. Expression of CXCL10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease. J. Immunol 179(2):1155-65, 2007. | ||
| Hoang, B., Trinh, A., and Edwards, R. A. Decreased MAPK- and PGE2-dependent IL-11 production in Gia2-/- colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007 Mar 1; [Epub ahead of print]. | ||
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Stiles, L.N., Hosking, M.P., Edwards, R.A., Strieter, R.M., and Lane, T. E., Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. Eur J. Immunol. 36(3):613-22, 2006. |
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| Edwards, R.A., and Smock, A.Z. Defective arachidonate release and PGE2 production in Gi?2-Deficient Intestinal and Colonic Subepithelial Myofibroblasts. Inflammatory Bowel Diseases 12 (3):153-165, 2006. | ||
| Ahlering, T.E., Eichel, L., Edwards, R.A., and Skarecky, D.W. The Impact of Obesity on Clinical Outcomes in Robotic Prostatectomy. Urology 65(4): 740-744, 2005. | ||
| Wu, J.Y., Zhang, Y., Edwards, R.A., Finegold, M.J., Jin, Y., Wu, M.X. Impairment of TGF-beta signaling in T cells of Gai2-/- mice. J. Immunol. 174 (10): 6122-6128, 2005. | ||
| Ahlering, T.E., Eichel, L., Edwards, R.A., Lee, D., and Skarecky, D.W. Robotic Radical Prostatectomy: A technique to reduce pT2 Positive Margins. Urology, 64(6):1224-8, 2004. | ||
| Ahlering,T.E., Woo, D., Eichel, L., Lee, D. I., Edwards, R. A., and Skarecky, D.W.. Robot-Assisted vs. Open Radical Prostatectomy: A comparison of one surgeon’s outcomes. Urology, 63(5):819-22, 2004 | ||
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Zhang, Y, Schlossman S.F., Edwards R.A., Ou C.N., Gu J., and Wu M.X.. Impaired Apoptosis, Extended Effector-Phase of Immune Responses, and Autoimmunity in IEX-1-Transgenic Mice. Proc. Natl. Acad. Sci. U S A, 99: 878-883, 2002. |
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| Zhao, B., Chua, S.S., Burcin, M.M., Edwards, R.A., Finegold, M.J., Tsai, S.Y., and DeMayo, F.J. Phenotypic consequences of lung-specific inducible expression of FGF-3. Proc. Natl. Acad. Sci. U S A 98(10): 5898-5903, 2001. | ||
| Smith, V.C., Edwards, R.A., Jorgensen, J.L., Goldfarb, R.A., Kadmon, D., Cagle, P. C., and Truong, L.D. Unilocular retroperitoneal cyst of mesothelial origin presenting as a renal mass. Arch. Pathol. Lab Med. 124: 766-9, 2000. | ||
| Tao, Y.S., Edwards, R.A., Tubb, B., Wang, S., Bryan, J., and McCrea, P.D. Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex. J. Cell Biol. 134:1271-81, 1996. | ||
| Dickason, R.R., Edwards, R.A., Bryan, J., and Huston, D.P. Versatile E. coli thioredoxin specific monoclonal antibodies afford convenient analysis and purification of prokaryote expressed soluble fusion protein. J. Immunol. Methods 185:237-44, 1995. | ||
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Edwards, R.A., Bryan, J. Fascins, a family of actin bundling proteins. Cell Motil. Cytoskeleton 32:1-9, 1995. |
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| Edwards R.A., Herrera-Sosa, H., Otto, J., and Bryan, J. Cloning and expression of a murine fascin homolog from mouse brain. J. Biol. Chem. 270:10764-70, 1993. | ||
| Bryan, J., Edwards, R.A., Matsudaira, P., Otto, J., and Wulfkuhle, J. Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product. Proc. Natl. Acad. Sci. U S A 90:9115-9119, 1993. | ||
| Graduate Programs |
Pathology-Anatomic and Clinical |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=4909 | |
| Last updated | 10/26/2011 | |