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Claudia H. Kawas

Professor, Neurology
School of Medicine

Professor, Neurobiology and Behavior
School of Biological Sciences

M.D., University of Louisville, Kentucky

Phone: (949) 824-2323
Fax: (949) 824-4165
Email: ckawas@uci.edu

University of California, Irvine
1121 Gillespie
Mail Code: 4540
Irvine, CA 92697

picture of Claudia H. Kawas

Research
Interests
Dementia and Memory Disorders, Geriatric Neurology, Epidemiology
   
URL The 90+ Study
   
Research
Abstract
Claudia Kawas, M.D., Al and Trish Nichols Chair in Clinical Neuroscience and Professor of Neurobiology & Behavior and Neurology, at the University of California, Irvine, is a geriatric neurologist and researcher in the areas of aging and dementia. Her work is concentrated on the epidemiology of aging and Alzheimer's disease, in the determinants of successful aging, longitudinal and clinical pathological investigations, clinical trials, and most recently, studies in cognitive and functional abilities of the Oldest Old (over 90 years of age). Dr. Kawas is a graduate of Swarthmore College (Pennsylvania), and completed her medical studies at the University of Louisville (Kentucky) and neurology residency training and a fellowship in dementia and aging at Albert Einstein College of Medicine, Bronx, New York. After 15 years on the faculty at Johns Hopkins School of Medicine, Dr. Kawas moved to the University of California, Irvine in 2000, where she is Principle Investigator of The 90+ Study and Associate Director of the UCI Institute for Memory Impairments and Neurological Disorders. Dr. Kawas serves on committees for the National Institutes of Health and the Scientific Advisory Board of several organizations, including the Medical and Scientific Advisory Council of the National Alzheimer’s Association, The Dana Foundation, and the United States Food & Drug Administration. Over the past 25 years, Dr. Kawas has published more than 100 peer-reviewed manuscripts, and has worked on numerous longitudinal studies of aging and dementia, including the Bronx Aging Study, the Baltimore Longitudinal Study of Aging (NIA), and most recently, The 90+ Study, a population based sample of more than 1,400 people aged 90 years and older.
   
Publications 1. Kawas CH, Corrada MM, Brookmeyer R, Morrison A, Resnick SM, Zonderman AB, Arenberg D. Visual Memory Predicts Alzheimer's Disease More Than a Decade Before Diagnosis. Neurology, 2003 Apr, 60(7):1089-1093. PMID 12682311

2. Kawas, CH, Early Alzheimer's Disease, New England Journal of Medicine, 2003;349:1056-63. PMID 12968090

3. Kawas, C. Diet and the Risk of Alzheimer’s Disease. Editorial. Annals of Neurology, June 2006, Vol. 59, No. 6, 877-879. PMID 16718710

4. Kawas CH, Corrada MM. Alzheimer’s and Dementia in the Oldest-Old: A Century of Challenges. Current Alzheimer Research, 2006, 3, 411-419. PMID 17168640

5. Kahle-Wrobleski K, Corrada MM, Li B, Kawas CH. Sensitivity and Specificity of the Mini-Mental State Examination for Identifying Dementia in the Oldest-Old: The 90+ Study. JAGS, 2007, 55:284-289. PMID 17302668

6. Kawas, C, The Oldest Old and the 90+ Study. Alzheimer’s & Dementia, January 2008, Vol. 4, Issue 1, Suppl 1, S56-S59. PMID 18632002

7. Corrada M, Brookmeyer R, Berlau D, Paganini-Hill A, Kawas C. Prevalence of dementia after age 90: results from The 90+ Study. Neurology 71;337-343, 2008. PMID 18596243

8. Head E, Corrada M, Kahle-Wrobleski K, Kim R, Sarsoza F, Goodus M, Kawas C. Synaptic Proteins, Neuropathology and Cognitive Status in the Oldest-Old. Neurobiology of Aging. 2009, 30, 1125-1134. PMID 18006193

9. Berlau DJ, Corrada MM, Head E, Kawas CH. ApoE ?2 is Associated with Intact Cognition but Increased Alzheimer Pathology in the Oldest-Old. Neurology. 2009;Mar 3;72(9):829-34. PMID 19255410; PMCID 2667799

10. Kravitz BA, Corrada MM, Kawas CH. High Levels of Serum C-Reactive Protein are Associated with Greater Risk of All-Cause Mortality, but not Dementia, In the Oldest-Old: Results from The 90+ Study. Journal of the American Geriatrics Society. 2009, Apr 57(4):641-6. PMID 19245412; NIHMS 102057

11. Berlau DJ, Corrada MM, Kawas C. The Prevalence of Disability in the Oldest-Old is High and Continues to Increase with Age: Findings from The 90+ Study. Int J Geriatr Psychiatry. 2009, Nov;24(11):1217-25. PMID 19259982; PMCID 2783224; NIHMS 115343

12. Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas C. Dementia Incidence Continues to Increase with Age in the Oldest-Old: The 90+ Study. Annals of Neurology. 2010;67:114-121. PMID: 20186856.

13. Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. Operationalizing Diagnostic Criteria for Alzheimer’s Disease and Other Age-related Cognitive Impairment – Part 2. Alzheimer’s & Dementia. 7, 2011, 35-52.

14. Brumback-Peltz C, Balasubramanian AB, Corrada MM, Kawas CH. Diagnosing Dementia in the Oldest-Old. Maturitas. 2011. 70;164-168.

15. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carillo MC, Thies B, Weintraub S, Phelps CH. The Diagnosis of Dementia Due to Alzheimer’s Disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association Workgroup. Alzheimer’s & Dementia. 2011. May 7(3):263-9.

16. Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Incidence of Dementia in Oldest-old with Amnestic MCI and Other Cognitive Impairments. Neurology. 2011. Nov 22;77(21):1906-12.

17. Robinson JL, Geser F, Corrada M, Berlau D. Neocortical and Hippocampal Amyloid-? and Tau Measures Associate with Dementia in the Oldest-Old. Brain. 2011. Dec;134(Pt 12):3708-15.

18. Berlau DJ, Corrada MM, Peltz CB, Kawas CH. Disability in the Oldest-old: Incidence and Risk Factors in The 90+ Study. American Journal of Geriatric Psychiatry. 2012. Feb;20(2):159-68.
   
Grants Clinical and Pathological Studies in the Oldest Old, National Institute on Aging 03/01/08 - 02/28/13. This project will examine biological, psychological, and social factors associated with functional, cognitive and behavioral capacities of individuals aged 90 years and older living independently.
   
Alzheimer's Disease Research Center of the University of California, Irvine (Clinical Core), National Institute on Aging, 04/01/10 - 03/31/15. The effort on this project is focused on clinical evaluation and characterization of research subjects in the ADRC.
   
Leukocyte-Derived Biomarkers as Predictors of Risk Progression in AD. National Institute on Aging, 03/01/08 - 02/28/13. This project seeks to discover and validate potential biomarkers of disease in subjects at risk for cognitive impairment and Alzheimer's disease.
   
18F-AV-45-A07, Avid, 07/01/09 - 06/30/11. This clinical industry trial is a phase III study of the correlation between florbetapir PET imaging and amyloid pathology.
   
Inflammation, Long-term Diabetes Characteristics, and Cognitive Decline, National Institute on Aging, 09/15/09 - 08/31/14. This prospective 5-year study examines how long-term characteristics of type 2 diabetes and inflammation affect the development of cognitive decline in non-demented 65 year old diabetic individuals.
   
Professional
Societies
American Neurological Association
Society of Neurosciences
American Academy of Neurology
American Geriatric Society
American Medical Association
National Arab American Medical Association
   
Research Centers Institute for Memory Impairments & Neurological Disorders (IMIND)
   
Clinic for Aging Research and Education (CARE) - The 90+ Study
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4890
   
Last updated 03/07/2012