Jennifer Simpson

Professor, Ophthalmology
School of Medicine

M.D., University of Michigan


Fellowship in Pediatric Ophthalmology, University of Michigan, 1999


Fellowship in Comprehensive Ophthalmology, University of Iowa, 1997


Residency in Ophthalmology, University of Iowa, 1997


Transitional Internship, St. Joseph Mercy Hospital, 1994

Phone: Appointments (949) 824-2020; Academic Office (949) 824-4122
Fax: (949) 824-4015
Email: jens@uci.edu

University of California, Irvine
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697

picture of Jennifer  Simpson

Research
Interests
Pediatric Ophthalmology and Adult Strabismus, Cystinosis
   
URL www.uceye.uci.edu/simpson.html
   
Academic
Distinctions
Honors and awards

1993 Alpha Omega Alpha
1988 Phi Beta Kappa
2016 2017 LA Magazine Top Doctor
2003 The Mark McGwire Foundation
2005 Honorary Chair, Blind Children’s Learning Center
2005 – 2008 Physician of Excellence – Orange Coast Magazine
2005 – 2006 Physician of Excellence – Orange County
2006 - 2016 Best Doctor, Best Doctor in America Database
2008 Orange Coast Top Doctors Award recognized by Orange Coast Magazine
2008 Top Ophthalmologist in America – Consumers’ Research Council of America
2011 Campus Community Research Incubator (CCRI) Award
2016 Southern California Super Doctors
2016 - 2017 Physician of Excellence – Orange Coast Magazine
   
Research
Abstract
Dr. Simpson's primary interests and expertise is in the field of pediatric ophthalmology and adult strabismus, including medical and surgical treatment of pediatric strabismus (eye misalignment), congenital cataracts, pediatric tearing disorders, as well as ocular genetics and congenital eye anomalies.
   
  TEXT BOOK CHAPTERS

DelMonte M, Archer S, Simpson J. Surgery to Correct Duane Syndrome and Brown Syndrome. Duane's Clinical Ophthalmology. Vol 6, Chap. 96. 2004. Lippincott Williams & Wilkens

PEER REVIEWED

Silverstein, FS, Simpson, J, Gordon, K, Hypoglycemia alters striatal amino acid efflux in perinatal rats: an in vivo microdialysis. Stroke, 1991; 22:928-32.

Gordon, K, Simpson, J, Statsman, D, Silverstein, FS. Effects of perinatal stroke on striatal amino acid efflux in rat studies with in vivo microdialysis. Stroke, 1991; 22:932.

Silverstein F.S., Naik, B, Simpson, J, Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Pediatric Research, 1991; 30:587-90.

Simpson J, Alford M, Keech R, Carter K. Metastatic rhabdomyosarcoma presenting as an isolated lateral rectus restriction". Journal of Pediatric Ophthal and Strabismu.1999;4:90-91

Brooks BP, Simpson JL, Leber SM, Robertson PL, Archer SM. Infantile spasms as a cause of acquired perinatal visual loss. Journal of the American Association for Pediatric Ophthalmology and Strabismus. 2002,6:385-8.

McCulley TJ, Mayer K, Dahr SS, Simpson J, Holland EJ. Aniridia and Optic Nerve Hypoplasia. Eye. 2005 Jul; 19(7): 762-4

Syres K, Harrison F, Jester JV, Simpson J, Roy S, Salomen D, Cherqui S. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood First Edition Paper, pre-published online June 8, 2009; DOI 10.1182/blood-2009-03-213934

Simpson JL, Nien CJ, Flynn K, Cherqui S, Jester JV. Quantative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in th Ctns-/- Knockout Mouse. Molecular Vision 2011;17:2212-2220. PMCID: PMC 3209421.

Simpson JL, Nien CJ, Flynn KJ, Jester JV. Evaluation of topical cysteamine therapy in the Ctns-/- mouse using in vivo confocal microscopy. Molecular Vision 2011;17:2649-2654. PMCID:PMC 3164685.

Simpson JL, Melia M, Yang MB, Buffenn AN, Cjiang, MF, Lambert SR. Current role of cryotherapy in retinopathy of prematurity; A Report by the American Academy of Ophthalmology. Ophthalmology 2012;119:873-77.

Chiang MF, Melia M, Buffenn AN, Lambert SR, Recchia FM, Simpson JL, Yang MB. Detection of Clinically Significant Retinopathy of Prematurity Using Wide-angle Digital Retinal Photography: A Report by the American Academy of Ophthalmology. 2012 Jun;119(6):1272-80. Epub 2012 Apr 27

Lambert SR, Melia M, Buffenn AN, Chiang MF, Simpson JL, Yang MB.
Rebound Tonometry in Children: a Eeport by the American Academy of Ophthalmology. 2013 Feb 7. doi:pii: S0161-6420(12)00979-7. 10.1016/j.ophtha.2012.09.058

Yang MB, Melia M, Lambert SR, Chiang MF, Simpson JL, Buffenn AN. Fibrin Glue for Closure of Conjunctival Incision in Strabismus Surgery: A Report by the American Academy of Ophthalmology. Ophthalmology. 2013 Jun 29. doi:pii: S0161-6420(13)00417-X. 10.1016/j.ophtha.2013.05.008.

BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL, J Neurovirol, “Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation”, Journal of NeuroVirology. 2015 May 22

Marcano D, Shin C, Lee B, Lucas C. Isenhart, Liu X, Li F, Jester J, Pflugfelder S, Simpson JL, Acharya G, “Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis”, Mol. Pharmaceutics, August 29, 2016; DOI: 10.1021/acs.molpharmaceut.6b00488



PUBLISHED ABSTRACTS

Simpson J, Gordon K, Silverstein FS. Influence of hypoglycemia on striatal extracellular fluid levels of neuroactive amino acids in perinatal rats: an in vivo microdialysis study. Annals of Neurology. 1989;26(3):144.

Gordon K, Simpson J, Statsman D, Silverstein FS. Perinatal hypoxic-ischemic brain injury alters striatal efflux in rat brain: an in vivo microdialysis study. Annual of Neurology. 1990;28:410.

Silverstein FS, Naik B, Simpson J. Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Society of Pediatric Research. 1991.

Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction subsequent to pars plana vitrectomy. Association for Research in Vision and Ophthalmology. 1996.

Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction in previously vitrectomiezed eyes for repair of macular holes. Association for Research in Vision and Ophthalmology. 1997.

Simpson J, Kardon RH. Identification of lateral geniculate nuclear lesion in quadruple sectoranpoia using novel MRI imaging. American Academy of Ophthalmology. 1997.

F.S. Jehan, D.S. Kim, Simpson J, B.D. Kuppermann, G.P. Resende, J.H. Sills, R.M. Kurtz. University of California - Irvine, Irvine, CA. Poster presentation, “Prevalence of Threshold Retinopathy in Infants Screened at a Tertiary Care University-Based Hospital.” ARVO – The Association for Research and Vision and Ophthalmology, Ft. Lauderdale, FL. April 24-29, 2004.

C. Nien Shy, T. Yamagami, K. Flynn, D. Carpenter, H. Levis, Simpson J, J.V. Jester. The Gavin S. Herbert Eye Institute, University of California, Irvine, Orange, CA. ARVO "Inmunologic Response of the Rabbit Cornea to Xenogenic and Allogeneic Bone Marrow Derived Mesenchymal Stem Cells” (MSC), May 04, 2009

Simpson J, Shy – Nien C, Flynn K, Cherqui S, Jester JV.
Corneal Imaging in the CTNS -/- Knockout Mouse Model. Association
for Research in Vision and Ophthalmology. May 2009
   
Grants • Knight’s Templar Eye Foundation Grant: Wavefront Aberrometry: Applications to Pathogenesis and Therapy of Amblyopia. 2002-2003.
   
• Clinical X Research Grant, University of California, Irvine. “Wavefront Aberrometry: Applications to Pathogenesis and Therapy of Amblyopia.” 2001-2002.
   
• Cystinosis Research Foundation Grant: “Evaluation of Novel Corneal Imaging and Therapeutics in the CTNS Knockout (Cystinosis) Mouse Model”. June 2008 -June 2010.
   
• Cystinosis Research Foundation Grant: “Novel Treatment Modalities for Corneal Cystinosis”. August 2010 to August, 2012.
   
• NIH RO1 EY022365: “Mesenchymal Stem Cell Therapy for Corneal Cystinosis”. April 2012-April 2016.
   
• Cystinosis Research Foundation Grant: “Nanowafer Drug Delivery for Corneal Cystinosis: Sustained-Release Cysteamine”. September 1, 2012 to August 31, 2014.
   
Cystinosis Research Foundation Grant: Development of Extended Release Cysteamine Nanowafer. September 1, 2014 to August 31, 2016
   
Gerber Company Grant: Cortical Visual Impairment in Very Low Birth Weight Preterm Infants: Correlation of Early Cranial UltrasoundFindings with Visual Function. May 1, 2015 to April 30, 2018
   
Professional
Societies
American Academy of Ophthalmology
Association for Research in Vision and Ophthalmology
Associate Member of the Association of University Professors
American Association for Pediatric Ophthalmology and Strabis
   
Graduate Programs Ophthalmology

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4862
   
Last updated 12/19/2016