Jennifer Simpson
Professor, Ophthalmology
School of Medicine
School of Medicine
M.D., University of Michigan
Fellowship in Pediatric Ophthalmology, University of Michigan, 1999
Fellowship in Comprehensive Ophthalmology, University of Iowa, 1997
Residency in Ophthalmology, University of Iowa, 1997
Transitional Internship, St. Joseph Mercy Hospital, 1994
Fellowship in Pediatric Ophthalmology, University of Michigan, 1999
Fellowship in Comprehensive Ophthalmology, University of Iowa, 1997
Residency in Ophthalmology, University of Iowa, 1997
Transitional Internship, St. Joseph Mercy Hospital, 1994
Phone: Appointments (949) 824-2020; Academic Office (949) 824-4122
Fax: (949) 824-4015
Email: jens@uci.edu
Fax: (949) 824-4015
Email: jens@uci.edu
University of California, Irvine
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
Research Interests
Pediatric Ophthalmology and Adult Strabismus, Cystinosis
Websites
Academic Distinctions
Honors and awards
1993 Alpha Omega Alpha
1988 Phi Beta Kappa
2016 2017 LA Magazine Top Doctor
2003 The Mark McGwire Foundation
2005 Honorary Chair, Blind Children’s Learning Center
2005 – Pres. Physician of Excellence – Orange Coast Magazine
2006 - Pres. Best Doctor, Best Doctor in America Database
2008 Orange Coast Top Doctors Award recognized by Orange Coast Magazine
2008 Top Ophthalmologist in America – Consumers’ Research Council of America
2011 Campus Community Research Incubator (CCRI) Award
2017 Honoree, United Cerebral Palsy of Orange County,Newport Beach, CA
2016 - Pres. Southern California Super Doctors
1993 Alpha Omega Alpha
1988 Phi Beta Kappa
2016 2017 LA Magazine Top Doctor
2003 The Mark McGwire Foundation
2005 Honorary Chair, Blind Children’s Learning Center
2005 – Pres. Physician of Excellence – Orange Coast Magazine
2006 - Pres. Best Doctor, Best Doctor in America Database
2008 Orange Coast Top Doctors Award recognized by Orange Coast Magazine
2008 Top Ophthalmologist in America – Consumers’ Research Council of America
2011 Campus Community Research Incubator (CCRI) Award
2017 Honoree, United Cerebral Palsy of Orange County,Newport Beach, CA
2016 - Pres. Southern California Super Doctors
Research Abstract
Dr. Jennifer Simpson graduated Magna Cum Laude, Phi Beta Kappa from Kenyon College. She obtained her medical degree from the University of Michigan, graduating Alpha Omega Alpha. Her primary expertise is in the field of pediatric ophthalmology, with clinical interests in cortical visual impairment, ultra-rare eye disease and congenital eye anomalies. Her research interests investigate novel drug therapies for corneal cystinosis, telemedicine in ultra-rare eye disease, and novel infant screening modalities for cortical visual impairment. She has been named a "Best Doctor in America" since 2005, is Board Certified in Ophthalmology and serves as a Board Examiner for the American Board of Ophthalmology. She serves on the Medical Advisory Board for the Cystinosis Research Foundation.
Publications
Pinxten A, Hua, M, Simpson J, Hohenfellner K, Levtchenko E, Casteels I., “Clinical Practice: A Proposed Standardized Ophthalmological Assessment for Patients with Cystinosis”, Ophthalmol Ther, March 16, 2017; doi: 10.1007/s40123-017-0089-3; PMID 28477325
TEXT BOOK CHAPTERS
DelMonte M, Archer S, Simpson J. Surgery to Correct Duane Syndrome and Brown Syndrome. Duane's Clinical Ophthalmology. Vol 6, Chap. 96. 2004. Lippincott Williams & Wilkens
PEER REVIEWED
Silverstein, FS, Simpson, J, Gordon, K, Hypoglycemia alters striatal amino acid efflux in perinatal rats: an in vivo microdialysis. Stroke, 1991; 22:928-32.
Gordon, K, Simpson, J, Statsman, D, Silverstein, FS. Effects of perinatal stroke on striatal amino acid efflux in rat studies with in vivo microdialysis. Stroke, 1991; 22:932.
Silverstein F.S., Naik, B, Simpson, J, Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Pediatric Research, 1991; 30:587-90.
Simpson J, Alford M, Keech R, Carter K. Metastatic rhabdomyosarcoma presenting as an isolated lateral rectus restriction". Journal of Pediatric Ophthal and Strabismu.1999;4:90-91
Brooks BP, Simpson JL, Leber SM, Robertson PL, Archer SM. Infantile spasms as a cause of acquired perinatal visual loss. Journal of the American Association for Pediatric Ophthalmology and Strabismus. 2002,6:385-8.
McCulley TJ, Mayer K, Dahr SS, Simpson J, Holland EJ. Aniridia and Optic Nerve Hypoplasia. Eye. 2005 Jul; 19(7): 762-4
Syres K, Harrison F, Jester JV, Simpson J, Roy S, Salomen D, Cherqui S. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood First Edition Paper, pre-published online June 8, 2009; DOI 10.1182/blood-2009-03-213934
Simpson JL, Nien CJ, Flynn K, Cherqui S, Jester JV. Quantative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in th Ctns-/- Knockout Mouse. Molecular Vision 2011;17:2212-2220. PMCID: PMC 3209421.
Simpson JL, Nien CJ, Flynn KJ, Jester JV. Evaluation of topical cysteamine therapy in the Ctns-/- mouse using in vivo confocal microscopy. Molecular Vision 2011;17:2649-2654. PMCID:PMC 3164685.
Simpson JL, Melia M, Yang MB, Buffenn AN, Cjiang, MF, Lambert SR. Current role of cryotherapy in retinopathy of prematurity; A Report by the American Academy of Ophthalmology. Ophthalmology 2012;119:873-77.
Chiang MF, Melia M, Buffenn AN, Lambert SR, Recchia FM, Simpson JL, Yang MB. Detection of Clinically Significant Retinopathy of Prematurity Using Wide-angle Digital Retinal Photography: A Report by the American Academy of Ophthalmology. 2012 Jun;119(6):1272-80. Epub 2012 Apr 27
Lambert SR, Melia M, Buffenn AN, Chiang MF, Simpson JL, Yang MB.
Rebound Tonometry in Children: a Eeport by the American Academy of Ophthalmology. 2013 Feb 7. doi:pii: S0161-6420(12)00979-7. 10.1016/j.ophtha.2012.09.058
Yang MB, Melia M, Lambert SR, Chiang MF, Simpson JL, Buffenn AN. Fibrin Glue for Closure of Conjunctival Incision in Strabismus Surgery: A Report by the American Academy of Ophthalmology. Ophthalmology. 2013 Jun 29. doi:pii: S0161-6420(13)00417-X. 10.1016/j.ophtha.2013.05.008.
BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL, J Neurovirol, “Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation”, Journal of NeuroVirology. 2015 May 22
Marcano D, Shin C, Lee B, Lucas C. Isenhart, Liu X, Li F, Jester J, Pflugfelder S, Simpson JL, Acharya G, “Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis”, Mol. Pharmaceutics, August 29, 2016; DOI: 10.1021/acs.molpharmaceut.6b00488
PUBLISHED ABSTRACTS
Simpson J, Gordon K, Silverstein FS. Influence of hypoglycemia on striatal extracellular fluid levels of neuroactive amino acids in perinatal rats: an in vivo microdialysis study. Annals of Neurology. 1989;26(3):144.
Gordon K, Simpson J, Statsman D, Silverstein FS. Perinatal hypoxic-ischemic brain injury alters striatal efflux in rat brain: an in vivo microdialysis study. Annual of Neurology. 1990;28:410.
Silverstein FS, Naik B, Simpson J. Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Society of Pediatric Research. 1991.
Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction subsequent to pars plana vitrectomy. Association for Research in Vision and Ophthalmology. 1996.
Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction in previously vitrectomiezed eyes for repair of macular holes. Association for Research in Vision and Ophthalmology. 1997.
Simpson J, Kardon RH. Identification of lateral geniculate nuclear lesion in quadruple sectoranpoia using novel MRI imaging. American Academy of Ophthalmology. 1997.
F.S. Jehan, D.S. Kim, Simpson J, B.D. Kuppermann, G.P. Resende, J.H. Sills, R.M. Kurtz. University of California - Irvine, Irvine, CA. Poster presentation, “Prevalence of Threshold Retinopathy in Infants Screened at a Tertiary Care University-Based Hospital.” ARVO – The Association for Research and Vision and Ophthalmology, Ft. Lauderdale, FL. April 24-29, 2004.
C. Nien Shy, T. Yamagami, K. Flynn, D. Carpenter, H. Levis, Simpson J, J.V. Jester. The Gavin S. Herbert Eye Institute, University of California, Irvine, Orange, CA. ARVO "Inmunologic Response of the Rabbit Cornea to Xenogenic and Allogeneic Bone Marrow Derived Mesenchymal Stem Cells” (MSC), May 04, 2009
Simpson J, Shy – Nien C, Flynn K, Cherqui S, Jester JV.
Corneal Imaging in the CTNS -/- Knockout Mouse Model. Association
for Research in Vision and Ophthalmology. May 2009
DelMonte M, Archer S, Simpson J. Surgery to Correct Duane Syndrome and Brown Syndrome. Duane's Clinical Ophthalmology. Vol 6, Chap. 96. 2004. Lippincott Williams & Wilkens
PEER REVIEWED
Silverstein, FS, Simpson, J, Gordon, K, Hypoglycemia alters striatal amino acid efflux in perinatal rats: an in vivo microdialysis. Stroke, 1991; 22:928-32.
Gordon, K, Simpson, J, Statsman, D, Silverstein, FS. Effects of perinatal stroke on striatal amino acid efflux in rat studies with in vivo microdialysis. Stroke, 1991; 22:932.
Silverstein F.S., Naik, B, Simpson, J, Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Pediatric Research, 1991; 30:587-90.
Simpson J, Alford M, Keech R, Carter K. Metastatic rhabdomyosarcoma presenting as an isolated lateral rectus restriction". Journal of Pediatric Ophthal and Strabismu.1999;4:90-91
Brooks BP, Simpson JL, Leber SM, Robertson PL, Archer SM. Infantile spasms as a cause of acquired perinatal visual loss. Journal of the American Association for Pediatric Ophthalmology and Strabismus. 2002,6:385-8.
McCulley TJ, Mayer K, Dahr SS, Simpson J, Holland EJ. Aniridia and Optic Nerve Hypoplasia. Eye. 2005 Jul; 19(7): 762-4
Syres K, Harrison F, Jester JV, Simpson J, Roy S, Salomen D, Cherqui S. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood First Edition Paper, pre-published online June 8, 2009; DOI 10.1182/blood-2009-03-213934
Simpson JL, Nien CJ, Flynn K, Cherqui S, Jester JV. Quantative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in th Ctns-/- Knockout Mouse. Molecular Vision 2011;17:2212-2220. PMCID: PMC 3209421.
Simpson JL, Nien CJ, Flynn KJ, Jester JV. Evaluation of topical cysteamine therapy in the Ctns-/- mouse using in vivo confocal microscopy. Molecular Vision 2011;17:2649-2654. PMCID:PMC 3164685.
Simpson JL, Melia M, Yang MB, Buffenn AN, Cjiang, MF, Lambert SR. Current role of cryotherapy in retinopathy of prematurity; A Report by the American Academy of Ophthalmology. Ophthalmology 2012;119:873-77.
Chiang MF, Melia M, Buffenn AN, Lambert SR, Recchia FM, Simpson JL, Yang MB. Detection of Clinically Significant Retinopathy of Prematurity Using Wide-angle Digital Retinal Photography: A Report by the American Academy of Ophthalmology. 2012 Jun;119(6):1272-80. Epub 2012 Apr 27
Lambert SR, Melia M, Buffenn AN, Chiang MF, Simpson JL, Yang MB.
Rebound Tonometry in Children: a Eeport by the American Academy of Ophthalmology. 2013 Feb 7. doi:pii: S0161-6420(12)00979-7. 10.1016/j.ophtha.2012.09.058
Yang MB, Melia M, Lambert SR, Chiang MF, Simpson JL, Buffenn AN. Fibrin Glue for Closure of Conjunctival Incision in Strabismus Surgery: A Report by the American Academy of Ophthalmology. Ophthalmology. 2013 Jun 29. doi:pii: S0161-6420(13)00417-X. 10.1016/j.ophtha.2013.05.008.
BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL, J Neurovirol, “Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation”, Journal of NeuroVirology. 2015 May 22
Marcano D, Shin C, Lee B, Lucas C. Isenhart, Liu X, Li F, Jester J, Pflugfelder S, Simpson JL, Acharya G, “Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis”, Mol. Pharmaceutics, August 29, 2016; DOI: 10.1021/acs.molpharmaceut.6b00488
PUBLISHED ABSTRACTS
Simpson J, Gordon K, Silverstein FS. Influence of hypoglycemia on striatal extracellular fluid levels of neuroactive amino acids in perinatal rats: an in vivo microdialysis study. Annals of Neurology. 1989;26(3):144.
Gordon K, Simpson J, Statsman D, Silverstein FS. Perinatal hypoxic-ischemic brain injury alters striatal efflux in rat brain: an in vivo microdialysis study. Annual of Neurology. 1990;28:410.
Silverstein FS, Naik B, Simpson J. Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study. Society of Pediatric Research. 1991.
Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction subsequent to pars plana vitrectomy. Association for Research in Vision and Ophthalmology. 1996.
Simpson J, Miller-Meeks, MJ. Outcomes of cataract extraction in previously vitrectomiezed eyes for repair of macular holes. Association for Research in Vision and Ophthalmology. 1997.
Simpson J, Kardon RH. Identification of lateral geniculate nuclear lesion in quadruple sectoranpoia using novel MRI imaging. American Academy of Ophthalmology. 1997.
F.S. Jehan, D.S. Kim, Simpson J, B.D. Kuppermann, G.P. Resende, J.H. Sills, R.M. Kurtz. University of California - Irvine, Irvine, CA. Poster presentation, “Prevalence of Threshold Retinopathy in Infants Screened at a Tertiary Care University-Based Hospital.” ARVO – The Association for Research and Vision and Ophthalmology, Ft. Lauderdale, FL. April 24-29, 2004.
C. Nien Shy, T. Yamagami, K. Flynn, D. Carpenter, H. Levis, Simpson J, J.V. Jester. The Gavin S. Herbert Eye Institute, University of California, Irvine, Orange, CA. ARVO "Inmunologic Response of the Rabbit Cornea to Xenogenic and Allogeneic Bone Marrow Derived Mesenchymal Stem Cells” (MSC), May 04, 2009
Simpson J, Shy – Nien C, Flynn K, Cherqui S, Jester JV.
Corneal Imaging in the CTNS -/- Knockout Mouse Model. Association
for Research in Vision and Ophthalmology. May 2009
Grants
• Knight’s Templar Eye Foundation Grant: Wavefront Aberrometry: Applications to Pathogenesis and Therapy of Amblyopia. 2002-2003.
• Clinical X Research Grant, University of California, Irvine. “Wavefront Aberrometry: Applications to Pathogenesis and Therapy of Amblyopia.” 2001-2002.
• Cystinosis Research Foundation Grant: “Evaluation of Novel Corneal Imaging and Therapeutics in the CTNS Knockout (Cystinosis) Mouse Model”. June 2008 -June 2010.
• Cystinosis Research Foundation Grant: “Novel Treatment Modalities for Corneal Cystinosis”. August 2010 to August, 2012.
• NIH RO1 EY022365: “Mesenchymal Stem Cell Therapy for Corneal Cystinosis”. April 2012-April 2016.
• Cystinosis Research Foundation Grant: “Nanowafer Drug Delivery for Corneal Cystinosis: Sustained-Release Cysteamine”. September 1, 2012 to August 31, 2014.
Cystinosis Research Foundation Grant: Development of Extended Release Cysteamine Nanowafer.
September 1, 2014 to August 31, 2016
Gerber Company Grant: Cortical Visual Impairment in Very Low Birth Weight Preterm Infants: Correlation of Early Cranial UltrasoundFindings with Visual Function. May 1, 2015 to April 30, 2018
Cystinosis Foundation of New Jersey: Cystinosis Telemedicine Project 2017
Professional Societies
American Academy of Ophthalmology
Association for Research in Vision and Ophthalmology
Associate Member of the Association of University Professors
American Association for Pediatric Ophthalmology and Strabis
Graduate Programs
Ophthalmology
Link to this profile
https://faculty.uci.edu/profile/?facultyId=4862
https://faculty.uci.edu/profile/?facultyId=4862
Last updated
04/10/2020
04/10/2020