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Irina F. Sevrioukova

Associate Researcher, Molecular Biology and Biochemistry
School of Biological Sciences

M.D., School of Medicine, Moscow, Russia


PH.D., Institute of Biomedical Chemistry, Moscow, Russia

Phone: (949) 824-1953
Fax: (949) 824-3280
Email: sevrioui@uci.edu

University of California, Irvine
3205 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697
Research
Interests 		Structure/function of flavo- and metalloenzymes, protein-protein interactions and molecular recognition, electron transport, protein crystallography
   
Academic
Distinctions 		1993-1995 - Postdoctoral Fellowship, Robert Welch Foundation;

1997-2000 - Institutional and Individual Postdoctoral National Research Service Awards, NIH.
   
Appointments Postdoctoral fellow, University of Texas Southwestern Medical Center, Dallas TX
Postdoctoral fellow, University of California, Irvine CA
   
Publications D. Ghezzi, I. Sevrioukova, F. Invernizzi, C. Lamperti, M. Mora, P. D'Adamo, F. Novara, O.Zuffardi, G. Uziel, M. Zeviani "Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor" (2010) Am. J. Hum. Genet. 86, 639-49.
   
  I. Sevrioukova, T. Poulos and I. Churbanova "Crystal structure of the putidaredoxin reductase- putidaredoxin electron transfer complex" (2010) J. Biol. Chem. 285, 13616-13620.
   
  I. Churbanova, T. Poulos and I. Sevrioukova "Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex" (2010) Biochemistry 49, 58-67.
   
  I. Sevrioukova "Redox-linked conformational dynamics in apoptosis-inducing factor" (2009) J. Mol. Biol. 390, 924-938.
   
  I. Churbanova and I. Sevrioukova "Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor" (2008) J. Biol. Chem.283,5622-5631.
   
  V. Kuznetsov, T. Poulos and I. Sevrioukova "Putidaredoxin-to-cytochrome P450cam electron transfer: differences between the two reductive steps required for catalysis" (2006) Biochemistry 45,11934-11944.
   
  I. Sevrioukova "Redox-dependent structural reorganization in putidaredoxin, a vertebrate-type [2Fe-2S] ferredoxin from Pseudomonas putida" (2005)J. Mol. Biol. 347,607-621.
   
  V. Kuznetsov, E. Blair, P.Farmer, T. Poulos, A. Pifferitti, and I. Sevrioukova "The putidaredoxin reductase-putidaredoxin electron transfer complex: theoretical and experimental studies"(2005)
J. Biol. Chem. 280,16135-16142
   
  I.F. Sevrioukova, H. Li, and T.L. Poulos "Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida, the Final Structural Component of the Cytochrome P450cam Monooxygenase" (2004) J. Mol. Biol. 336 889-902
   
  I.F. Sevrioukova, C. Garcia, H. Li, B. Bhaskar, and T.L. Poulos "Crystal Structure of Putidaredoxin, the [2Fe,2S] Component of the P450cm Monooxygenase System from Pseudomonas putida" (2003) J. Mol. Biol. 333, 377-392
   
Grant National Institute of Health grant GM67637
   
Professional
Society 		American Society for Biochemistry and Molecular Biology
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4606
   
Last updated 07/04/2010