Robert K. Moyzis

Professor, Biological Chemistry
School of Medicine

PH.D., The Johns Hopkins University, 1978

Phone: (949) 824-1849, 1870
Fax: (949) 824-3403
Email: rmoyzis@uci.edu

University of California, Irvine
128, 131 Plumwood House
Irvine, CA 92697


Research
Interests
Human genome project, complex genetic disease, recent evolutionary selection of human genes
   
URLs www.ucihs.uci.edu/biochem/faculty/moyzis.html
   
www.genome.uci.edu
   
Research
Abstract
For the 8 years prior to joining the Faculty at UCI, I was Director of the Center for Human Genome Studies at Los Alamos National Laboratory, the first Genome Center to be established as part of the Human Genome Project (HGP). My major research interests were mapping and sequencing human DNA and the identification of genomic regions involved in chromosome structure/ function. Notable contributions included: 1) the identification and cloning of the human telomere; 2) the first crystal structure of telomeric DNA; 3) The generation of high-resolution YAC/cosmid physical maps of human chromosomes 5 and 16, and 4) the identification and cloning of various human disease genes, including Fanconi Anaemia Group A and Familial Mediterranean Fever. Following my move to UCI, my laboratory has focused on 1) using genome technology and information to identify and sequence genes/DNA regions involved in human chromosome stability, with emphasis on telomeres and centromeres, and 2) exploiting and developing genomic/bioinformatic technology to assess human DNA variability, with emphasis on complex neurogenetic diseases/ traits. Recent highlights include A) integration of telomere sequences with the human genome sequence, as part of the international HGP, B) obtaining evidence of positive selection acting at the human dopamine receptor D4 (DRD4) gene locus, associated with attention deficit/hyperactivity disorder (ADHD) and the personality trait of novelty seeking, and C) uncovering the evidence of extensive recent positive selection throughout the human genome.
   
Publications All publications at www.genome.uci.edu
   
  Y.C. Ding, H.C. Chi, D.L. Grady, A. Morishima, J.R. Kidd, K.K. Kidd, P. Flodman, M.A. Spence, S. Schuck, J.M. Swanson, Y.P. Zhang, R.K. Moyzis, Evidence of positive selection acting at the human dopamine receptor D4 gene locus, Proc. Natl. Acad. Sci. USA 99, 309-314 (2002).
   
  D.L. Grady, H.C. Chi, Y.C. Ding, M. Smith, E. Wang, S. Schuck, P. Flodman, M.A. Spence, J.M. Swanson, R.K. Moyzis, High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder, Mol. Psychiatry 8, 536-545 (2003).
   
  E. Wang, Y.C. Ding, P. Flodman, J.R. Kidd, K.K. Kidd, D.L. Grady, O.A. Ryder, M.A. Spence, J.M. Swanson, R.K. Moyzis, The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus, Am. J. Hum. Genet. 74, 931-944 (2004).
   
  The International Human Genome Sequencing Consortium, Finishing the euchromatic sequence of the human genome, Nature 431, 931-945 (2004).
   
  E.T. Wang, G. Kodama, P. Baldi, R.K. Moyzis, Global landscape of recent inferred Darwinian selection for Homo sapiens, Proc. Natl. Acad. Sci. USA 103, 135-140 (2006).
   
Graduate Programs Cancer Biology

Developmental Biology and Genetics

   
Research Center Genomics and Bioinformatics
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=4558
   
Last updated 03/06/2007