Lee BardwellAssociate Professor, Developmental & Cell Biology |
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Research Interests |
How cell signaling networks work, and how they achieve specificity. | |
| URL | darwin.bio.uci.edu/~bardwell/ | |
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Academic Distinctions |
2004-05 National Academies of Sciences Keck Futures Initiative Grantee 1999-02 Beckman Young Investigator Award, Beckman Foundation 1999-02 New Investigator Award - Pharmacological Sciences, Burroughs Wellcome Fund 1997-00 Special Fellow Award, Leukemia Society of America 1993-96 NIH National Research Service Award Postdoctoral Fellowship 1987-91 Predoctoral Training Grant, National Cancer Institute 1984 Phi Beta Kappa 1984 Sigma Xi |
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| Appointments | 1993-98 Postdoctoral Fellow, University of California, Berkeley (Laboratory of Prof. Jeremy Thorner) | |
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Research Abstract |
Signal transduction networks are a crucial part of the circuitry by which a cell regulates and coordinates its growth and developmental program, and its response to the external environment. Faulty or malfunctioning signaling pathways lie at the heart of the molecular pathology of many diseases, including cancer. The signaling components we study have been highly conserved through evolution, and are thus of great importance to basic biology, as well as medicine. Research Interests: Conserved signaling pathways controlling growth and development in yeast and mammalian cells. Mechanisms of specificity in signal transduction, especially protein kinase signaling. Regulation of mitogen-activated protein kinase (MAPK) cascades in yeast and mammalian cells. Protein-protein interactions and their role in signaling. |
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| Publications | My latest publications are listed on my lab website. | |
| Grants | NIH - R01 GM60366 (PI: Bardwell) “MAP Kinase Cascade Signal Transmission and Specificity" | |
| NIH - R33 GM69013 (PI: E. Mjolsness), “A Signal Transduction Pathway Database/Modeling System” | ||
| National Academies Keck Futures Initiative (PI: Bardwell) “Intracellular Signaling Specificity: Theoretical and Computational Explorations” | ||
| (This is just a partial listing of past and present grants.) | ||
| Graduate Programs |
Developmental Biology and Genetics Cancer Biology Biotechnology Cellular and Molecular Biosciences Mathematical and Computational Biology Stem Cell Biology |
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| Research Centers | ||
| UCI/Chao Family Cancer Center | ||
| UCI Institute for Genomics and Bioinformatics | ||
| UCI Developmental Biology Center | ||
| UCI Center for Complex Biological Systems | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=4549 | |
| Last updated | 02/10/2009 | |