Bruce BlumbergProfessor, Developmental & Cell Biology Professor |
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Research Interests |
molecular embryology, molecular biology, developmental biology, functional genomics, endocrinology, pharmacology, high-throughput screening | |
| URLs | lab web site | |
| blumberg.bio.uci.edu | ||
| Appointments |
Department of Biological Chemistry, UCLA School of Medicine 1988-1992 Staff Scientist, Salk Institute for Biological Studies, La Jolla, CA 1992-1998 |
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Research Abstract |
Our laboratory is broadly interested in the study of gene regulation and intercellular signaling during embryonic development. We study a family of regulatory proteins called nuclear hormone receptors and their ligands. These receptors are all members of the steroid receptor superfamily and are ligand-regulated transcription factors that regulate important events during embryonic development and adult physiology. PATENTS Mouse peroxisome proliferator-activated receptor gamma – US 5,861,274 Human peroxisome proliferator-activated receptor gamma – US 6,200,802 Human peroxisome proliferators-activated receptor gamma compositions and methods - US 6,815,168 High throughput functional screening of cDNAs – US 6,274,321 Method, polypeptides, nucleotide sequence of XOR-6 (BXR), a vitamin D-like receptor from Xenopus – US 6,391,847 Steroid-activated nuclear receptors and uses therefore (SXR) - US 6,756,491, US 6,809,178 Transgenic mice expressing a human SXR receptor polypeptide – US 6,984,773 |
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| Publications | Zhou, C.C., Tabb, M.M., Nelson, E.L., Grün, F., Verma, S., Sadatrafiei, A., Lin, M., Mallick, S., Forman, B.M., Thummel, K.E., and Blumberg, B. (2006) Mutual repression between steroid and xenobiotic receptor and NF-?B signaling pathways links xenobiotic metabolism and inflammation. J. Clin. Invest, 116, 2280-2289. | |
| Grün, F., Watanabe, H., Zamanian, Z., Maeda, L., Arima, K., Chubacha, R., Gardiner, D.M., Iguchi, T., Kanno, J., and Blumberg, B. (2006) Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol., 20, 2141-2155. | ||
| Grün, F., and Blumberg, B. (2007) Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Reviews in Endocrinology and Metabolism, 8, 161-171. | ||
| Arima, K., Shiotsugu, J., Niu, R., Khandpur, R., Martinez, M., Shin, Y., Koide, T., Cho, K.W.Y., Kitayama, A., Ueno, N., Chandraratna, R.A.S., and Blumberg, B. (2005) Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays. Dev. Dyn., 232, 414-431. | ||
| Zhou, C. Tabb, M.M., Sadatrafiei, A., Grün, F., and Blumberg, B. (2004) Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes Drug Metab. Dispos., 32, 1075-1082. | ||
| Shiotsugu, J., Katsuyama, Y., Arima, K., Baxter, A., Koide, T., Song, J., Chandraratna, R.A.S., and Blumberg, B. (2004) Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development, 131, 2653-2667. | ||
| Tabb, M.M., Kholodovych, V., Grün, F., Zhou, C., Welsh, W.J., and Blumberg, B. (2004) Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the Steroid and Xenobiotic Receptor (SXR) Environmental Health Perspectives, 112, 163-169. | ||
| Tabb, M.M., Sun, A., Zhou, C., Grün, F., Errandi, J., Romero, K., Pham, H., Inoue, S., Mallick, S., Lin, M., Forman, B.M., and Blumberg, B. (2003) Vitamin K2 regulation of bone homeostasis is mediated by the orphan receptor, SXR. J. Biol. Chem. 278, 43919-43927 | ||
| Koide, T., Downes, M., Chandraratna, R.A.S., Blumberg, B. and Umesono, K. (2001) Active repression of RAR signaling is required for head formation. Genes Dev., 15, 2111-2121. | ||
| Graduate Programs |
Developmental Biology and Genetics Mechanisms of Gene Expression Cell Biology Biomedical Engineering |
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| Research Centers | Developmental Biology Center | |
| Institute for Genomics and Bioinformatics | ||
| Cancer Research Institute | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=4539 | |
| Last updated | 04/17/2008 | |