UC Irvine - Faculty Profile System

Steven P. Gross

Assistant Professor, Developmental & Cell Biology
School of Biological Sciences

Physics & Astronomy
School of Physical Sciences

B.A., University of Chicago, Physics

PhD-Physics, University of Texas at Austin

Phone: (949) 824-3159
Fax: (949) 824-4709
Email: sgross@uci.edu

University of California
2222 Natural Sciences I
University of California, Irvine
Mail Code: 2300
Irvine, CA 92697



Research Interests	Laser tweezers, optical tweezers. lasers, molecular motors, kinesin, dynein, cargo transport,myosin, drosophila, biophysics, cross-disciplinary, motor coordination

URL	bioweb.bio.uci.edu/sgross/

Research Abstract	Cells are highly structured, and this structure is created and maintained using the cytoskeleton in conjunction with molecular motors. My research combines genetic and biochemical manipulations with biophysical techniques ( laser-tweezers, single-particle tracking and analysis, and computer modeling) to study cargo transport in vivo. My primary goal is to understand the extent to which the activity of different molecular motors is coordinated, and the detailed physical changes in motor activity that result in alteration of net cargo transport.

Publications	S. P. Gross, M. C. Tuma, S. W. Deacon, A. S. Serpinskaya A. R. Reilein and V. I. Gelfand, “Interactions and Regulation of Molecular Motors in Xenopus Melanophores”, to appear Mar. 4 issue J. Cell Bio., 2002

	S.P Gross, M. Welte, S.M. Block, and E.F. Wieschaus, “Coordination of opposite-polarity microtubule motors”, to appear Feb 18 issue J. Cell Biol., 2002

	L.W. Enquist, M.J. Tomishima, S. Gross, G.S. Smith, “Directional spread of an alpha-herpsesvirus in the nervous system”, Veter. Microb. 2266, 1-12 (2002).

	G.A. Smith, S.P Gross, and L.W. Enquist, “Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons”, PNAS 98 3466-70 (2001)

	S.P Gross, M. Welte, S.M. Block, and E.F. Wieschaus, “Dynein-mediated cargo transport In vivo. A switch controls travel distance.”, J. Cell Biol. 148 945-56 (2000).

	S.P. Gross, M. Welte, M. Postner, S. M. Block, and E.F. Wieschaus, “Developmental and Genetic Regulation of Vesicle Transport in Drosphila Embryos”, Cell 92, 547 (1998).

	K. Visscher, S. P. Gross, and S. M. Block, “Construction of Multiple-Beam Optical Traps with Nanometer-Resolution Position Sensing”, IEEE Jl. Sel. Top. Quant. Electr., 2, 1066 (1996).

Professional Societies	American Society of Cell Biology Biophysical Society

Link to this profile	http://www.faculty.uci.edu/profile.cfm?faculty_id=4538

Last updated	07/29/2005

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Steven P. Gross