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Hartmut Luecke

Professor, Molecular Biology and Biochemistry
School of Biological Sciences

Professor, Physiology & Biophysics
School of Medicine

Professor, Computer Science
Donald Bren School of Information and Computer Sciences

Director, Center for Biomembrane Systems

B.S., Heidelberg College, OH


Ph.D., Rice University

Email: hudel@uci.edu

University of California, Irvine

Mail Code: 3900
Irvine, CA 92697-3900

picture of Hartmut  Luecke

Research
Interests
Protein crystallography Structure function studies Membrane proteins Bacteriorhodopsin Annexin G protein-coupled receptors (GPCR) Structure-based drug design
   
URLs Hartmut Luecke's UCI webpage
   
The UCI Center for Biomembrane Systems
   
Research
Abstract
See web page
   
Publications A transporter converted into a sensor, a phototaxis signaling mutant of bacteriorhodopsin at 3.0 Å.
Spudich EN, Ozorowski G, Schow EV, Tobias DJ, Spudich JL, Luecke H.
J Mol Biol. 2012 Jan 20;415(3):455-63. Epub 2011 Nov 22.
   
  Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.
Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9449-54. Epub 2011 May 23.
   
  Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization.
Stagno J, Aphasizheva I, Bruystens J, Luecke H, Aphasizhev R.
J Mol Biol. 2010 Jun 11;399(3):464-75. Epub 2010 Apr 18.
   
  Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia.
Pathuri P, Nguyen ET, Ozorowski G, Svärd SG, Luecke H.
J Mol Biol. 2009 Jan 30;385(4):1098-112. Epub 2008 Nov 20.
   
  Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore.
Luecke H, Schobert B, Stagno J, Imasheva ES, Wang JM, Balashov SP, Lanyi JK.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16561-5. Epub 2008 Oct 15.
   
  Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form.
Pathuri P, Vogeley L, Luecke H.
J Mol Biol. 2008 Oct 31;383(1):62-77. Epub 2008 May 7.
   
Professional
Societies
ACA
APS
Alexander von Humboldt Foundation
   
Graduate Programs Structural Biology and Molecular Biophysics

Biotechnology

   
Research Centers Cancer Research Institute
   
Center for Biomembrane Systems
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=3283
   
Last updated 01/25/2012