Frederic Y.M. Wan

Professor, Mathematics
School of Physical Sciences

Professor, Mechanical & Aerospace Engineering
The Henry Samueli School of Engineering

S.B., Massachusetts Institute of Technology, 1959, Mathematics

S.M. and Ph.D. Mathematics, June, 1993 and September, 1965, MIT

Phone: (949) 824-5529
Fax: (949) 824-7993

University of California, Irvine
510B Rowland Hall
Mail Code: 3875
Irvine, CA 92697

picture of Frederic Y.M. Wan

Applied Mathematics, Solid Mechanics, Resource Economics, Biomathematics
Honors and Awards:
**Arthur Beaumont Distinguished Service Award, Canadian Applied Mathematics Society, 1991
**Foreign Member, Russian Academy of Natural Sciences, 1999 -
**Fellow: American Academy of Mechanics (AAM), 1981, American Society of Mechanical Engineers (ASME), 1987; American Association for the Advancement of Science (AAAS), 1995; Society for Industrial and Applied Mathematics (SIAM), 2010.

**University of British Columbia: Director, Institute of Applied Mathematics and Statistics (1974-83)
**University of Washington: Chair, Department of Applied Mathematics (1983-88); Divsional Dean of Natural and Mathematical Sciences, College of Arts & Sciences (1988-92)
**Natural Science and Engineering Council of Canada: Member (1980-83) and Chairman (1982-83), Committee of Pure and Applied Mathematics
**National Science Foundation: Program Officer, Appl. Math. Program, DMS (1986-87); Division Director, DMS (January, 1993 - December, 1994)
**MIT: MIT Educational Council (1974-79) MIT Visiting Committee for Mathematics (1991-93)
**University of California, Irvine: Vice Chancellor for Research and Dean of Graduate Studies (1995-2000)
Chair of Board of Trustees, IPAM, UCLA (1999-2002)
Member of Scientific Committee, ZCAM, Tsinghua University, 2002 -
Member of Advisory Committee, Center for the Mathematical Sciences, Renmin University of China, 2015 -.

Editorial Board Membership: 1) Studies in Appl. Math. 84- ; 2) Canadian Appl. Math. Quarterly, 93- ; 3) International J. Solids & Strucutres 96- ; 4) World Sci. Publ. 95- ; 5) J. Mech. Materials & Structures (JoMMS), 05 - ; 6) International J. Num. Anal. & Modeling, Series B, 10 -16.

Professional Societies: Canadian Applied Mathematics Society (CAMS/SCMA): Council Member 1980-82, President 1983-85, Past President 1985-87. American Mathematical Society (AMS): Committee of Committees (1995-97), Science Policy Committee (1995-97). Society for Industrial and Applied Mathematics (SIAM): Educational Committee (1983-87), Representative on the U.S. National Committee on Theoretical and Applied Mechanics (1991-93, 2001-), Science Policy Committee (1990-92,1995-) Mathematical Association of America (MAA)
Appointments Department of Mathematics, MIT, 1965-67
**Copyrights on Books: 1) Mathematical Models and Their Analysis, Harper and Row, February, 1989. 2) Introduction to the Calculus of Variations and Its Applications, Chapman & Hall, January, 1995.
**Recent Presentations: 2004-05 - SIAM Conferences on the Life Sciences (7/11-16/04, Portland, OR), AIM's 5th Int'l Conf. on Dyn. Syst. & Diff. Eq'ns (6/16-19/04, Pomona, CA); 2003-04 - Int'l Conf. Math. & Its Applications (5/28-31/04, City Univ. of Hong Kong), Math. Seminar (5/21/04, Peking Univ.), Mechanics Seminar (5/14/04, Peking Univ.), Comp. Math. Seminar (4/23/04, Xian Jaotong Univ.), Mechanics Seminar (4/9/04, Tsinghua Univ.), 5th ICIAM (7/7-11/03, Sydney, Australia); 2002-03 - W.M. Keck Seminars in Comp. Biology (5/21/03, UCLA), 3rd So.Calif. Appl. Math. Symp. (5/3/2003, UC Irvine), Annual SIAM Meeting (7/8-12/2002, Philadelphia, PA).
Publications Timing of CD8 T cell effector responses in viral infections, Royal Society Open Science, 2016, to appear. (with S.R. Stipp, A. Iniguez, and D. Wodarz)
  Transient Feedback and Robust Signaling Gradients, Int. J. Num. Anal. & Modeling, Series B, 13 (2), 2016, Pgs.175-200. (with A. Simonyan)
  Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms, Interface, J. Royal Soc. 12 . 2014, Pgs. 1014-26. (with W.-C. Lo, S. Zhou, A.D. Lander and Q. Nie)
  A new approach to feedback for robust signaling gradients, Studies in Appl. Math. 133, 2014, 18-51. (with T. Kushner abd A. Simonyan)
  Fastest time to cancer by loss of tumor suppressor genes, Bull. Math Bio.. 76. 2014, 2737-2784. (with C. Sanchez-Tapia)
  Robustness of signaling gradient in Drosophila wing imaginal disc, J. DCDS-B (Discrete and Continuous Dynamical Systems, Series B) Vol. 16 (3) 2011, Pgs. 835-866. (with J. Lei, A.D. Lander, and Q. Nie)
  Size-normalized robustness of Dpp gradient in Drosophila wing imaginal disc, JoMMS Vol. 6 (1-4), 2011, Pgs. 321-350. (with A.D. Lander, Q, Nie, and B. Vargas)
  Genetic instability in cancer: an optimal control problem, Studies in Appl. Math., Vol. 125(1), 2010, Pgs. 1 - 10. (with A. Sadovsky and N. L. Komarova)

Spatial dynamics of multi-state cell lineages in tissue stratification, Biophysical J. Vol. 99 (10), 2010, Pgs. 3145-3154. (with C.-S. Chiou, W. Lo, K. Gokoffski,Y.-T.Zhang, A.D. Lander, A.L. Calof, and Q. Nie)
  Feedback regulation in multistage cell lineages, Math. Biosci. & Eng., 6(1), 2009, Pgs. 59-82. (W.-C. Lo, C.-S. Chou, K. Gokoffski, A.D. Lander, A.L. Calof and Q. Nie)
  Compact integration factor methods in high spatial dimension, J. Comp. Phys., 227, 2008, Pgs. 5238-5525. (with Q. Nie, F.Y.M. Wan, Y.-T. Zhang and X.-F. Liu)
  Selective pressures for and against genetic instability in cancer: a time-dependent problem, J. Royal Society, Interface, 2007, Online, June 19, 2007, doi: 10.1098/rsif.2007.1054. (with N. Komarova and A. Sadovsky)
  Elastodynamics of embryonic epidermal wound closure, Studies in Appl. Math., 118, 2007, Pgs. 365-395. (with A. Sadovsky)
  Time to first spike in Hodgkin-Huxley stochastic systems, Physica A - Stat. Mech. Applic., 351 (2-4), 2005, Pgs. 427-438. (with H.C. Tuckwell)
  Effects of Sog on Dpp-receptor binding, SIAM J. Appl. Math., 65, 2005, Pgs. 1748 - 1771. (with Y. Lou and Q. Nie)
  Formation of the BMP activity gradient in the Drosophila embryo, Dev. Cell, 8, 2005, Pgs. 519-5?? [plus supplement]. (with C.M. Mizutani, Q. Nie, Y.-T. Zhang, P. Vilmos, E. Bier, J.L. Marsh and A.D. Lander)
  Spatially distributed morphogen synthesis and morphogen gradient formation, Math. Biosci. & Eng. (MBE), 2 , 2005, Pgs. 239 – 262. (with A.D. Lander and Q. Nie)
  Stress boundary conditions for plate bending, Int. J. Solids Structure Vol. 40, 2003, 4107-4123. (A Special Issue in honour of Arthur. W. Leissa on his 70th Birthday)
  Determination of Firing Times for the Stochastic Fitzhugh-Nagumo Neuronal Model, Neural Comp., vol. 15, 2003, 143-159. (with H.C. Tuckwell and Rodriguez)
  Do morphogen gradients arise by diffusion? Dev. Cell, vol. 2, 2002, 785-796. (with A.D. Lander and Q. Nie)
  Nature of equilibria and effects of drug treatments in some viral population dynamical models, IMA J. Math. Appl. Med. & Biol. vol. 17, 2000, Pgs. 311-327. (with H.C. Tuckwell)
  Locational equilibrium models for publicly owned residential land, Natural Resource Modeling vol. 13(2), 2000, 219-246.
  A thick hollow sphere compressed by equal and opposite concentrated axial loads, an asymptotic solution, SIAM J. Appl. Math., vol. 59, 1999, 1080-1097. (with R. D. Gregory & T. I. Milac)
Grant NIH grant R01GM67247 (PI), 2002-2006, 2006-2010; 2010-2014; NIH grant R25GM-096989 (PI), 2011 - 2016; NIH grant P50GM-066051 (Co-PI), 2007-2012, 2013-2018; NSF DMS (SCREMS) grant DMS-0112416 (PI), 2001-2003, DMS (UBM) grant DMS-1129008 (PI), 2011 - 2016
American Academy of Mechanics
American Society for Mechanical Engineers (ASME)
Canadian Applied Mathematical Society (CAMS/SCMA)
Society for Industrial and Applied Mathematics (SIAM)
American Mathematical Society (AMS)
Mathematical Association of America (MAA)
Other Experience
Research Center Center for Research on Complex Biological Systems
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Last updated 02/09/2016