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Steven G. Potkin

Professor of Psychiatry, Psychiatry & Human Behavior
School of Medicine

Robert R. Sprague Chair in Brain Imaging, Psychiatry & Human Behavior
School of Medicine

Director, Brain Imaging Center, Psychiatry & Human Behavior
School of Medicine

M.D., Washington University

Phone: (949) 824-8040
Fax: (949) 824-3324
Email: sgpotkin@uci.edu

University of California, Irvine
5251 California Ave., Ste 240
Mail Code: 1680
Irvine, CA 92617

picture of Steven G. Potkin

Research
Abstract
My major interests are to investigate the underlying causes of schizophrenic and manic depressive illness by using neurioimaging, neurophysiology, neuropsychology and post-mortem neuroscience investigations, based on the recent findings in neuroscience, my goal is to develop and assess novel treatment for these illnesses.
   
Available Technologies
Publications Zung WW, Gianturco D, Pfeiffer E, Wang HH, Bridge TP, Potkin SG: Pharmacology of Depression in the Aged: Evaluation of Gerovital H3 as an Antidepressant Drug. Psychosomatics 15:127-131, 1974.

Bridge TP, Potkin SG, Zung WK, Soldo B: Effectiveness of Suicide Prevention Centers: An Epidemiological Study. Journal of Nervous and Mental Diseases 164:18-24, 1977.

Karoum F, Moyer-Schwing J, Potkin SG, Wyatt RJ: Presence of Free Sulfate and Glucuronide Conjugated 3-Methoxy-4-Hydroxyphenylglycol (MHPG) in Human Brain, Cerebrospinal Fluid and Plasma. Brain Research 125: 333-339, 1977.

Nasrallah HA, Donnelly EF, Bigelow LB, Calimlim LR, Rogol A, Potkin SG, Rauscher FP, Wyatt RJ, Gillin JC: Inhibition of Dopamine Synthesis in Chronic Schizophrenia: Clinical Ineffectiveness of Metyrosine. Archives of General Psychiatry 34: 649-655, 1977.

Karoum FK, Moyer-Schwing J, Potkin SG, Wyatt RJ: Plasma Concentrations of Some Acidic and Alcoholic Metabolites Derived from M- and P-Tyramine, Octopamine and Catecholamines in Humans. Communications in Psychopharmacology 1:343-352, 1977.

Potkin SG, Cannon HE, Murphy DL, Wyatt RJ: Are Paranoid Schizophrenics Biologically Different from Other Schizophrenics? New England Journal of Medicine 298:61-66, 1978.

Potkin SG, Gillin JC, Rogol A, Nasrallah HA, Wyatt RJ: Baclofen: Lack of Effect on Human Plasma Prolactin. Communications in Psychopharmacology 2:297-300, 1978.

Wyatt RJ, Potkin SG, Murphy DL: Platelet Monoamine Oxidase Activity in Schizophrenia: A Review of the Data. American Journal of Psychiatry 136:377-385, 1979.

Karoum F, Nasrallah H, Potkin SG, Chuang L, Moyer-Schwing J, Phillips I, Gillin JC, Wyatt RJ: Mass Fragmentography of Phenylethylamine, M- and P-Tyramine and Related Amines in Plasma, Cerebrospinal Fluid, Urine and Brain. Journal of Neurochemistry 33:201-212, 1979.

Jeste DV, Potkin SG, Sinha S, Feders S, Wyatt RJ: Tardive Dyskinesia: Reversible and Persistent. Archives of General Psychiatry 36:585-590, 1979.

Potkin SG, Karoum F, Chuang WW, Cannon-Spoor HE, Phillips I, Wyatt RJ: Phenylethylamine in Paranoid Chronic Schizophrenia. Science, 204:470-471, 1979.

Kleinman JE, Potkin SG, Rogol A, Buchsbaum MS, Murphy DL, Gillin JC, Nasrallah H A, Wyatt RJ: A Correlation between Platelet Monoamine Oxidase Activity and Plasma Prolactin Concentrations in Man. Science 206:474-281, 1979.

Wise CD, Potkin SG, Bridge P, Wyatt RJ: An Endogenous Inhibitor of Platelet MAO Activity in Chronic Schizophrenia: Failure to Replicate. American Journal of Psychiatry 136:1336-1337, 1979.

Kobes RD, Potkin SG, Wise CD, Bridge TP, Neckers LM, Wyatt RJ: Some Kinetic Parameters of Platelet Monoamine Oxidase in Chronic Schizophrenia. Psychiatry 1:179-185, 1979.

Wise CD, Bridge TP, Potkin SG, Wyatt RJ: Platelet Monoamine Oxidase: Studies on the Rate of the Heat Inactivation in Normal, Chronic Paranoid and Non-paranoid Schizophrenic Groups. Psychiatry Research 1:187-190, 1979.

Jeste DV, Stoff DM, Potkin SG, Wyatt RJ: Tardive Dyskinesia: Study on an Animal Model. Indian Journal of Psychiatry 21:360-369, 1979.

Potkin SG, Wyatt RJ, Karoum D: Phenylethylamine and Phenylacetic Acid in Urine of Chronic Schizophrenic Patients and Controls. Psychopharmacology Bulletin 16:52-54, 1980.

Wise CD, Potkin SG, Bridge TP, Phelps BH, Cannon-Spoor HE, Wyatt RJ: Sources of Error in the Determination of Platelet Monoamine Oxidase: A Review of Methods. Schizophrenia Bulletin 6:245-251, 1980.

Wyatt RJ, Potkin SG, Bridge TP, Phelps BH. Wise CD: Monoamine Oxidase in Schizophrenia: An Overview. Schizophrenia Bulletin 6:199-207, 1980.

Shore D, King S, Kaye W, Torrey EF, Winfrey HJ, Potkin SG, Weinberger DR, Savory J, Willis MR, Wyatt RJ: Serum and Cerebrospinal Fluid Aluminum and Circulating Parathyroid Hormone in Primary Degenerative (Senile) Dementia. Neurotoxicology 1:55-63, 1980.

Freed WF, Kleinman JE, Karson CN, Potkin SG, Murphy DL, Wyatt RJ: Eye-Blink Rates and Platelet Monoamine Oxidase Activity in Chronic Schizophrenic Patients. Biological Psychiatry 15:239-244, 1980.

DeLisi LE, Wise CD, Potkin SG, Zalcman SG, Phelps BH, Lovenberg W, Wyatt RJ: Dopamine-Beta-Hydroxylase, Monoamine Oxidase and Schizophrenia. Biological Psychiatry 15(6):899-905, 1980.

Rosenblatt JE, Pary RH, Bigelow LB, DeLisi LE, Wagner RL, Kleinman JE, Weinberger DR, Potkin SG, Shiling D, Jeste DV, Alexander P, Wyatt RJ: Measurement of Serum Neuroleptic Concentrations by Radioreceptor Assay: Concurrent Assessment of Clinical Response and Toxicity. Psychopharmacology Bulletin 16:78-80, 1980.

Luchins DJ, Freed WJ, Potkin SG, Rosenblatt JE, Gilling JD, Wyatt RJ: Gluten and Haloperidol Absorption. Biological Psychiatry 15:819-820, 1980.

Weinberger DR, Cannon-Spoor E, Potkin SG, Wyatt RJ: Poor Premorbid Adjustment and CT Scan Abnormalities in Chronic Schizophrenia. American Journal of Psychiatry 137:1410-1413, 1980.

Jeste DV, Neckers LM, Wagner RL, Wise CD, Staub RA, Rogol A, Potkin SG, Bridge T P, Wyatt RJ: Lymphocyte Monoamine Oxidase and Plasma Prolactin and Growth Hormone in Tardive Dyskinesia. Journal of Clinical Psychiatry 42:75-77, 1981.

Wyatt RJ, Karoum F, Stoff DM, Kleinman JE, Gillin JC, Jeste DV, Potkin SG: Monoamine Oxidase, Phenylethylamine, Norepinephrine and Schizophrenia. Clinical Genetics 437-442, 1981.

Bridge TP, Jeste DV, Wise CD, Potkin SG, Phelps BH, Wyatt RJ: Platelet Monoamine Oxidase in an Aged General Population and Elderly Chronic Schizophrenia. Psychopharmacology Bulletin 17:103-104, 1981.

Wyatt RJ, Potkin SG, Kleinman JE, Weinberger DR, Luchins DJ, Jeste DV: The Schizophrenia Syndrome: Examples of Biological Tools for Subclassification. Journal of Nervous and Mental Disease 169:100-112, 1981.

Potkin SG, Weinberger DR, Kleinman JE, et al: Wheat Gluten Challenge in Schizophrenia Patients. American Journal of Psychiatry 138:1208-1211, 1981.

DeLisi L, Wise CD, Bridge TP, Rosenblatt JE, Wagner R, Morihisa J, Karson C, Potkin SG, Wyatt RJ: A Probable Neuroleptic Effect on Platelet Monoamine Oxidase Activity. Psychiatry Research 4:95-107, 1981.

Jeste DV, DeLisi LE, Zalcman S, Wise CD, Phelps BH, Rosenblatt JE, Potkin SG, Bridge TP, Wyatt RJ: A Biochemical Study of Tardive Dyskinesia in Young Male Patients. Psychiatry Research 4:327-331, 1981.

DeLisi LE, Weinberger DR, Neckers LM, Potkin SG, Shiling D, Wyatt RJ: Quantitative Determination of Immunoglobulin Concentrations in CSF and Plasma of Schizophrenic Patients. British Journal of Psychiatry 139:513-519, 1981.

Jeste DV, Doongaji DR, Panjwani D, Datta M, Potkin SG, Karoum F, Thatte S, Wyatt RJ: Cross-Cultural Study of a Biochemical Abnormality in Paranoid Schizophrenia. Psychiatry Research 3:341-352, 1981.

Jeste DV, Kleinman JE, Potkin SG, Luchins DJ, Weinberger DR: Ex Uno Multi: Subtyping the Schizophrenic Syndrome. Biological Psychiatry 17:199-222, 1982.

Cannon-Spoor HE, Potkin SG, Wyatt RJ: Measurement of Premorbid Adjustment in Chronic Schizophrenia. Schizophrenia Bulletin 8:470-484, 1982.

Potkin SG, Shore D, Torrey EF, Weinberger DR, Gillin JC, Henkin RI, Agarwal RP, Wyatt RJ: Cerebrospinal Fluid Zinc Concentrations in Ex-Heroin Addicts and Patients with Schizophrenia: Some Preliminary Observations. Biological Psychiatry, 17:1315-1322, 1982.

Karson CN, Bridge TP, Phelps BP, Wise CD, Potkin SG, Wyatt RJ: The Effect of Oral Glucose on Platelet Monoamine Oxidase. Biological Psychiatry 7:1011-1015, 1982.

Shore D, Potkin SG, Weinberger DR, Torrey EF, Henkin R, Agarwal A, Gillin JC, Wyatt RJ: CSF Copper in Chronic Schizophrenia. American Journal of Psychiatry 140:754-756, 1983.

Linnoila M, Karoum F, Potkin SG, Wyatt RJ, Potter WZ: Amelioration of Psychosis with Carbidopa. British Journal of Psychiatry, 1983.

Potkin SG, Weinberger DR, Linnoila M, Wyatt RJ: Low CSF 5-Hydroxyindoleacetic Acid in Schizophrenic Patients with Enlarged Ventricles. American Journal of Psychiatry 140:21-25, 1983.

Potkin SG, Shen YC, Xia ZY, Phelps BH, Korpi E, Pardes HP: Psychopharmacological Research in the Peoples Republic of China. Psychopharmacological Bulletin, 1983.

Potkin SG, Cannon-Spoor HE, DeLisi LE, Neckers LM, Wyatt RJ: Plasma Phenylalanine, Tyrosine and Tryptophan Concentrations in Schizophrenic Patients and Controls. Archives of General Psychiatry 40:749-752, 1983.

Potkin SG, Gu NF, Zhou DF: Novel Technique for Collection and Storage of Biological Samples. Lancet ii:1304, 1983.

Kaufmann C, Weinberger D, Yolken RH, Torrey EF, Potkin SG: CSF Cytomegalovirus Antibody Levels in Schizophrenia. Lancet 12(2): 1137, 1983.

Potkin SG, Chang WH: Some Practical Problems in Schizophrenia Research. Taipei Psychiatric Journal 73:191-195, 1983.

Mered B, Albrecht P, Torrey EF, Weinberger DR, Potkin SG, Winfrey CJ: Failure to Isolate Virus from CSF of Schizophrenics. Lancet (2): 919, 1983.

Bridge PT, Dilip V, Jeste C, Wise D, Potkin SG, Phelps BH, Wyatt RJ: Schizophrenic Outcome in Late Life: Symptom State and Platelet Monoamine Oxidase Activity. Psychiatric Research 11:91-97, 1983.

Potkin SG, Shen YC, Zhou DF, Shu L, Pardes H: Biological Differences Between Orientals and Non-Orientals: Pharmacokinetics and Dexamethasone Suppression Testing. Psychopharmacology Bulletin, 1983.

Bridge TP, Jeste DV, Wise CD, Potkin SG, Phelps BH, Wyatt RJ: Schizophrenic Outcome in Late Life: Symptom State and Platelet Monoamine Oxidase Activity. Psychiatry Research 11(2):91-97, 1984.

Karoum F, Potkin SG, Chuang L, Murphy DL, Leibowitz MR, Wyatt RJ: Phenylacetic Acid (PAA) Excretion in Schizophrenia and Depression: The Origins of PAA in Man. Biological Psychiatry 19(2):165-178, 1984.

Linnoila M, Karoum F, Potkin SG, Wyatt RJ, Potter WZ: Amelioration of Psychosis with
Carbidopa: A Case Report. British Journal of Psychiatry 144:428-431, 1984.

Potkin SG, Shen Y, Pardes H, Phelps BH, Zhou DF, Shu L, Korpi E, Wyatt RJ: Haloperidol Concentrations Elevated in Chinese Patients. Psychiatry Research 12:167-172, 1984.

Potkin SG, Shen Y, Zhou DF, Pardes H, Shu L, Phelps B, Poland R: Does a Therapeutic Window For Plasma Haloperidol Exist?: Preliminary Chinese Data. Psychopharmacology Bulletin 21:59-61, 1985.

Zhang SZ, Zhou GZ, Xi GF, Gu NF, Xiz ZY, Yao JL, Chang JK, Webber E, Potkin SG: Lower CSF Level of Dynorphin (1-8) Immunoreactivity in Schizophrenic Patients. Neuropeptides 5: 553-556, 1985.

Potkin SG, Zetin M, Stamenkovic V, Kripke D, Bunney WE Jr.: Seasonal Affective Disorder: Prevalence Varies with Latitude and Climate. 15th Congress, Collegium Internationale Neuro-Psychopharmacologicum. Clinical Neuropharmacology 9:181-183, 1986.

Potkin SG, Hahn R, Sramek J: Plasma Neuroleptic Concentrations: In Search of a Therapeutic Window. Clinical Neuropharmacology 9:256-258, 1986.

Kojima T, Matsushima E, Moriya H, Ando K, Takashashi R, Shimazono Y, Kharazmi M, Herrera J, Potkin SG: Eye Movements in Remitting and Non-Remitting Schizophrenia. Clinical Neuropharmacology 9:277-279, 1986.

Potkin SG, Urbanchek MS, Kirch DG, Bunney WE Jr.: Evaluation of Optimal Doses of A Neuroleptic: Preliminary Results. Clinical Neuropharmacology 9:437-439, 1986.

Halevie-Goldman B, Potkin SG, Poyourow P: AIDS-Related Complex Presenting as Psychosis. American Journal of Psychiatry 144(7):964, 1987.

Zetin M, Potkin SG, Urbanchek M: Melatonin in Depression. Psychiatric Annals, 17(10):676-681, October 1987.

Potkin SG, Bell K, Plon L, Bunney WE Jr.: Rapid Antidepressant Response with SAMe: A Double-Blind Study. The Alabama Journal of Medical Sciences, 25(3), 1988.

Sramek J, Potkin SG, Hahn R: Neuroleptic Plasma Concentrations and Clinical Response: In Search of a Therapeutic Window. Drug Intelligence and Clinical Pharmacy 22:373-380, 1988.

Heh CW, Herrera J, DeMet E, Potkin SG, Costa J, Sramek J, Hazlett E, Buchsbaum MS: Neuroleptic-Induced Hypothermia Associated with Amelioration of Psychosis in Schizophrenia. Neuropsychopharmacology 1(2), 1988.

Bell K, Plon L, Bunney WE Jr., Potkin SG: S-Adenosylmethionine the Treatment of Depression: A Controlled Clinical Trial. American Journal of Psychiatry 145:1110-1114, 1988.

Hullett FJ, Potkin SG, Levy, Alan B, Ciasca R: Depression Associated With Nifedipine-Induced Calcium Channel Blockade. American Journal of Psychiatry 145(10):1277-1279, 1988.

Heh C, Potkin SG, Pickar D, Costa J, Herrera J, Sramek J, DeMet E: Serum Homovanillic Acid Concentrations in Carbamazepine-Treated Chronic Schizophrenics. Biological Psychiatry 25(5):639-641, 1989.

Kojima T, Potkin SG, Kharazmi M, Matsushima E, Herrera J, Shimazono Y: Limited Eye Movement Patterns in Chronic Schizophrenic Patients. Psychiatry Research 28:307-314, 1989.

Rice D, Potkin SG, Jin Y, Isenhart R, Heh C, Sramek J, Costa J, Sandman C: EEG Alpha Photic Driving Abnormalities in Chronic Schizophrenia. Psychiatry Research, 30:313-324, 1989.

Guich SM, Buchsbaum MS, Burgwald L, Wu J, Haier R, Asarnow R, Nuechterlein KH, Potkin SG: Effects of Attention on Frontal Distribution of Delta Activity and Cerebral Metabolic Rate in Schizophrenia. Schizophrenia Research 2:439-448, 1989.

Sramek J, Guarano V, Herrera J, Potkin SG: Patterns of Neuroleptic Usage in Continuously Hospitalized Chronic Schizophrenic Patients: Evidence for Development of Drug Tolerance. The Annals of Pharmacotherapy 24:7-24, 1990.

Sramek J, Costa J, Jin Y, Gulasekaram B, Khaled E, Potkin SG: Tiospirone in Chronic Treatment-Resistant Schizophrenics. Drug Investigation 2(1):65-66, 1990.

Buchsbaum MS, Nuechterlein KH, Haier RJ, Lagunas-Solar M, Wu JC, Sicotte N, Hazlett E, Asarnow R, Potkin SG, Guich S: Glucose Metabolic Rate in Normals and Schizophrenics during the Continuous Performance Test Assessed by Positron Emission Tomography. British Journal of Psychiatry 156:216-227, 1990.

O'Dell S, LaHoste G, Widmark C, Shapiro R, Potkin SG, Marshall J: Chronic Treatment with Clozapine or Haloperidol Differentially Regulates Dopamine and Serotonin Receptors in Rat Brain. Synapse 6:146-153, 1990.

Jin Y, Potkin SG, Rice D, Sramek J, Isenhart R, Costa J, Heh C, Sandman, C: Abnormal EEG Responses to Photic Stimulation in Schizophrenic Patients. Schizophrenia Bulletin 16(4):627-634, 1990.

Buchsbaum MS, Haier R, Katz M, Tafalla R, Lottenberg S, Potkin SG, Bunney WE Jr.: Testing Neural Models of Schizophrenia with Positron Emission Tomography. Clinical Neuropharmacology 13, 1990.

Swanson JM, Posner MI, Potkin SG, Bonforte S, Youpa D, Cantwell D, Crinella F: Activating Tasks for the Study of Visual-Spatial Attention in ADHD Children: A Cognitive Anatomical Approach. Journal of Child Neurology 6:119-127, 1991.

Jones EG, Hendry SHC, Liu XB, Potkin SG, Hodgins S, Tourtellotte W: A Method for Fixation of Previously Fresh-Frozen Human Adult and Fetal Brains that Preserves Histological Quality and Immunoreactivity. Journal of Neuroscience Method 44:133-144, 1992.

Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha S, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek PA, Trenary M, Tafalla R, Reynolds C, Bunney WE Jr.: Frontostriatal Disorder of Cerebral Metabolism in Never-Medicated Schizophrenics. Archives of General Psychiatry 49(12):935-942, 1992.

Buchsbaum MS, Potkin SG, Siegel BV, Lohr J, Katz M, Gottschalk LA, Marshall JF, Lottenberg S, Tang CY, Abel L, Plon L, Bunney WE Jr.: Striatal Metabolic Rate and Clinical Response to Neuroleptics in Schizophrenia. Archives of General Psychiatry, 49(12):966-974, 1992.

Buchsbaum MS, Potkin SG, Marshall J, Lottenberg S, Heh CW, Tafalla R, Reynolds C, Bunney WE Jr.: Effects of Clozapine and Thiothixene on Glucose Metabolic Rate in Schizophrenia. Neuropsychopharmacology 6(3):155-163, 1992.

Akbarian S, Bunney WE Jr., Potkin SG, Wigal SB, Hagman JO, Sandman CS, Jones EG: Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate-Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development. Archives of General Psychiatry 50(3):169-177, 1993.

Akbarian S, Viñuela A, Kim J, Potkin SG, Bunney WE Jr., Jones EG: Distorted Distribution of Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development. Archives of General Psychiatry 50(3):178-187, 1993.

Wu J, Buchsbaum MS, Moy K, Denlea N, Kesslak P, Tseng H, Plosnaj D, Hetu M, Potkin SG, Bracha S, et al: Olfactory Memory in Unmedicated Schizophrenics. Schizophrenia Research 9(1):41-7, 1993.

Wigal T, Christian DL, Wigal SB, Swanson JM, Crinella FM, Potkin SG, Carreon D, Ackerland V, Dean DB: Classification of Types of Tardive Dyskinesia in a Developmentally Disabled Population at a Public Residential Facility. Journal of Developmental and Physical Disabilities 5:55-69, 1993.

Siegel BV Jr., Buchsbaum MS, Bunney WE Jr., Gottschalk LA, Haier RJ, Lohr JB, Lottenberg S, Najafi A, Nuechterlein KH, Potkin SG: Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. American Journal of Psychiatry 150(9):1325-1336 1993.

Shapiro DH Jr., Potkin SG, Jin Y, Brown B, Carreon D, Wu JC: Measuring the Psychological Construct of Control: Discriminant, Divergent, and Incremental Validity of the Shapiro Control Inventory and Rotter’s and Wallstons’ Locus of Control Scales. International Journal of Psychosomatics 40(1-4):35-46, 1993.

Potkin SG, Buchsbaum MS, Jin Y, Tang C, Telford J, Friedman G, Lottenberg S, Najafi A, Gulasekaram B, Costa J, Richmond GH, Bunney WE Jr.: Clozapine Effects on Glucose Metabolic Rate in Striatum and Frontal Cortex. The Journal of Clinical Psychiatry 55(9):63-66, 1994.

Potkin SG, Bera R, Gulasekaram B, Costa J, Hayes S, Jin Y, Richmond G, Carreon D, Sitanggan K, Gerber B, Telford J, Plon L, Plon H, Park L, Chang YJ, Oldroyd J, Cooper T: Plasma Clozapine Concentrations Predict Clinical Response in Treatment-Resistant Schizophrenia. The Journal of Clinical Psychiatry 55(9):133-136, 1994.

Bell KM, Potkin SG, Carreon D, Plon L: S-adenosylmethionine Blood Levels in Major Depression: Changes with Drug Treatment. ACTA Neurologica Scandinavia 154:15-18, 1994.

Schroeder J, Buchsbaum MS, Siegel BV, Geider FJ, Haier RJ, Lohr J, Wu JC, Potkin SG: Patterns of Cortical Activity in Schizophrenia. Psychological Medicine 24:947-955, 1994.

Akbarian S, Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE Jr., Jones EG: Gene Expression for Glutamic Acid Decarboxylase is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics. Archives of General Psychiatry 52:258-266, 1995.

Jin Y, Sandman CA, Wu JC, Bernat J, Potkin SG: Topographic Analysis of EEG Photic Driving in Normal and Schizophrenic Subject. Clinical Electroencephalography 26(2): 102-107, 1995.

Jin Y, Potkin SG, Sandman C: Clozapine Increase EEG Photic Driving in Clinical Responders. Schizophrenia Bulletin 21(2):263-268, 1995.

Bunney BG, Potkin SG, Bunney WE Jr.: New Morphological Findings in Schizophrenia: A Neurodevelopmental Perspective. Clinical Neuroscience 3(2):81-88, 1995.

Akbarian S, Huntsman M, Kim J, Tafazzoli A, Potkin S, Bunney WE Jr., Jones E: GABAA Receptor Subunit Gene Expression in Human Prefrontal Cortex: Comparison of Schizophrenics and Controls. Cerebral Cortex 5(6):550-560, 1995.

Hong CCH, Jin Y, Potkin SG, Wu JC, Buchsbaum M, Callaghan G, Nudleman K, Gillin JC: Language in Dreaming and Regional Alpha Power. Sleep 19(3):232-235, 1996.

Jin Y, Potkin SG: P50 Changes with Visual Interference in Normal Subjects: A Sensory Distraction Model for Schizophrenia. Clinical Electroencephalography 27(3), 1996.

Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE Jr., Jones EG: Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients. Archives of General Psychiatry 53(5):425-436, 1996.

Helmeste DM, Tang SW, Bunney WE Jr., Potkin SG, Jones EG: Decrease in Sigma but No Increase in Striatal Dopamine D4 Sites in Schizophrenic Brains. European Journal of Pharmacology 314:R3-R5, 1996.

Akbarian S, Sucher NJ, Bradley D, Tafazzoli A, Trinh D, Hetrick WP, Potkin SG, Sandman CA, Bunney WE Jr., Jones EG: Selective Alterations in Gene Expression for NMDA Receptor Subunits in Prefrontal Cortex of Schizophrenics. Journal of Neuroscience 16(1):19-30, 1996.

Hetrick W, Sandman C, Bunney WE Jr., Jin Y, Potkin SG, White MH: Gender Differences in the Gating of the Auditory Evoked Potential in Normal Subjects. Biological Psychiatry 39(1):51-8, 1996.

Schroeder J, Buchsbaum MS, Siegel BV, Gieder FJ, Lohr J, Tang C, Wu J, Potkin SG: Cerebral Metabolic Activity Correlates of Subsyndromes in Chronic Schizophrenia. Schizophrenia Research 19(1):41-53, 1996.

Hong C, Potkin SG, Antrobus JS, Dow BM, Callachan GM, Gillin JC: REM Sleep Eye Movement Correlate with Visual Imagery in Dreaming: A Pilot Study. Psychophysiology 34(3):377-381, 1997.

Tang SW, Helmeste DM, Fang, H, Li M, Vu R, Bunney WE Jr., Potkin SG, Jones EG: Differential Labeling of Dopamine and Sigma Site by [3H] Nemonapride and [3H] Raclopride in Postmortem Human Brains. Brain Research 765:7-12, 1997.

Wigal SB, Swanson JM, Potkin SG: Lateralized attentional deficits in drug free and medicated schizophrenic patients. Neuropsychologia 35(12):1519-1525, 1997.

Bunney BG, Potkin SG, Bunney WE Jr.: Neuropathological Studies of Brain Tissue in Schizophrenia. J Psychiatric Res 31(2):159-173, 1997.

Jin Y, Potkin SG, Sandman CA, Bunney WE Jr.: Electroencephalographic Photic Driving in Patients with Schizophrenia and Depression. Biological Psychiatry 41(4):496-499, 1997.

Baysal BE, Potkin SG, Farr JE, Higgins MJ, Korcz J, Gollin SM, James MR, Evans GA, Richard CW 3rd: Bipolar Affective Disorder Partially Cosegregates with a Balanced t(9;11) (p24;q23.1) Chromosomal Translocation in a Small Pedigree. American Journal of Medical Genetics 81(1):81-91, 1998.

Jin, Y, Potkin SG, Sandman CA, Bunney WE Jr.: Topographic Analysis of EEG Photic Driving in Patients with Schizophrenia Following Clozapine Treatment, Clinical Electroencephalography 29(2):73-78, 1998.

Jin Y, Bunney WE Jr., Sandman CA, Patterson JV, Fleming K, Moenter JR, Kalali AH, Hetrick WP, Potkin SG: Is P50 Suppression a Measure of Sensory Gating in Schizophrenia? Biological Psychiatry 43:873-878, 1998.

Jin Y, Potkin SG, Patterson JV, Sandman CA, Hetrick WP, Bunney WE Jr.: Effects of P50 Temporal Variability on Sensory Gating in Schizophrenia. Psychiatry Research 70(2):71-81, 1998.

Huntsman MM, Tran BV, Potkin SG, Bunney WE Jr., Jones EG: Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics. Proceedings of the National Academy of Sciences of the United States of America 95(25):1266-1271, 1998.

Potkin SG, Jin Y, Bunney B, Costa J, Gulasekaram B: Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. American Journal of Psychiatry 156:145-147, 1999.

Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP, Laksminarayanan M, the Ziprasidone Study Group: Ziprasidone 80 mg.day and 160/mg day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 6-week placebo-controlled trial. Neuropsychopharmacology 20(5):491-505, 1999.

Basile VS, Masellis M, Badri F, Paterson AD, Meltzer HY, Lieberman JA, Potkin SG, Macciardi F, Kennedy JL: Association of the MscI Polymorphism of the Dopamine D3 Receptor Gene with Tardive Dyskinesia in Schizophrenia. Neuropsychopharmacology 21(1):17-27, 1999.

Vellas B, Inglis F, Potkin S, et al.: Interim results from an international clinical trial with rivastigmine evaluating a 2-week titration rate in mild to severe Alzheimer’s disease in patients. International Journal of Geriatric Psychopharmacology 1:140-44, 1998.

Bunney WE Jr., Hetrick WP, Bunney BG, Patterson JV, Jin Y, Potkin SG, Sandman CA: Structured Interview for Assessing Perceptual Anomalies. Schizophrenia Bulletin 25(3):577-592, 1999.

Jin Y, Castellanos A Jr., Solis ER Jr., Potkin SG: EEG Resonant Responses in Schizophrenia: A Photic Driving Study with Improved Harmonic Resolution. Schizophrenia Research. Schizophrenia Research, 44(3):213-20, 2000.

Moayeri SE, Cahill L, Jin Y, Potkin SG: Relative Sparing of Emotionally Influenced Memory in Alzheimer’s Disease. Neuroreport 11(4), 2000.

Vincent JB, Neves-Pereira ML, Paterson AD, Yamamoto E, Parikh SV, Macciardi F, Gurling H, Potkin SG, Pato CN, Azevedo H, Kovacs M, Davies M, Lieberman JA, Meltzer HY, Petronis A, Kennedy JL: An Unstable Trinucleotide Repeat Region on Chromosome 13 Implicated in Spinocerebellar Ataxia: A Common Expansion Locus. The American Journal of Human Genetics 66(3):819-829, 2000.

Patterson JV, Jin Y, Gierczak M, Hetrick WP, Potkin S, Bunney WE Jr., Sandman CA: Effects of Temporal Variability on P50 and the Gating Ratio in Schizophrenia. Archives of General Psychiatry 57(1): 57-64, 2000.

Basile VS, Ozdemir V, Masellis M, Walker ML, Meltzer HY, Lieberman JA, Potkin SG, Kalow W, Macciardi FM, Kennedy JL: A Functional Polymorphism of the Cytochrome P450 1A2 (CYP1A2) Gene: Association with Tardive Dyskinesia in Schizophrenia. Molecular Psychiatry, 5(4):410-7, 2000.

Popken, GJ; Bunney, WE Jr; Potkin, SG; Jones, EG. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics. Proceedings of the National Academy of Sciences of the United States of America, 97(16):9276-80, 2000.

Cahill, L; Haier, RJ; White, NS; Fallon, J; Kilpatrick, L; Lawrence, C; Potkin, SG; M: Sex Difference in Amygdala Activity During Emotionally Influenced Memory Storage, Neurobiology of Learning and Memory, 075: 1-9, 2001.

Fleming, K; Thyrum, PT; Yeh, C; Vargo, DL; Potkin, SG: Cognitive Improvements in Psychotic Patients Treated with ‘Seroquel’ (Quetiapine Fumarate): An Exploratory Study Journal of Clinical Psychopharmacology, 21(5): 527-529, 2001.

Daniel, DG; Potkin, SG; Reeves, KR; Swift, RH; Harrigan, EP: Intramuscular (IM) Ziprasidone 20 mg is Effective in Reducing Acute Agitation Associated with Psychosis: A Double-Blind, Randomized Trial. Psychopharmacology 155:128-134, 2001.

Potkin, SG; Anand, R; Alva, G; Fallon, JH; Keator, D; Carreon, D; Messina, J; Wu, JC; Hartman, R; Fleming, K: Brain Metabolic and Clinical Effects of Rivastigmine in Alzheimer’s Disease. International Journal of Neuropsychopharmacology, 4, 223-230 (2001).

Potkin, SG; Thyrum, PT; Bera, R; Carreon, D; Maguire, G; Kalali, A; Yeh, Chiao: Effect of Combination Quietiapine/Lithium Therapy on Lithium Pharmacokinetics and Tolerability, Clinical Therapeutics, 24 (11): 1809-1823, 2002.

Potkin, SG, Fleming, K, Jin, Y., Gulasekaram, B.: Clozapine Enhances Neurocognition and Clinical Symptomatology More Than Standard Neuroleptics, Journal of Clinical Psychopharmacology, 21(5): 479-483, 2001.

Albert, K.A., Hemmings, H.C., Adamo, A.I.B., Potkin, S.G., Akbarian, S., Sandman, C.A., Cotman, C.W., Bunney, W.E., Greengard, P.: Evidence for Decreased DARPP-32 in the Prefontal Cortex of Schizophrenics. Archives of General Psychiatry, 59(8):705-712, 2002.

Kojima, T, Matsushima, E, Ohta, K,Toru, M, Han, Y, Shen, Y, Moussaoui, D, David, I, Sato, K, Yamashita, I, Kathmann, N, Hippius, H, Thanvundayil, JX, Lal, S, Vasavan Nair, NP, Potkin, SG, Prilipko, L: Stability of exploratory eye movements as a marker of schizophrenia – a WHO multi-center study, Schizophrenia Research, 52:203-213, 2001.

Asnis, GM, Hameedi, FA, Goddard, AW; Potkin, SG, Black, D, Jameel, M, Desagani, K, Woods, SW. Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients. Psychiatry Research 103(1):1-14, 2001.

Potkin, SG, Thyrum, PT, Yeh, C, Arvanitis, LA, and the Pharmacokinetic Study Group: Effect of Fluoxetine and Impipramine on the Pharmacokinetics and Tolerability of the Antipsychotic Quetiapine, Journal of Clinical Psychopharmacology, 22(2) 174-182, 2002.

Potkin, SG, Thyrum, PT, Alva, G, Bera, R, Yeh, C, Arvanitis, LA: The Safety and Pharmacokinetics of Quetiapine When Coadministered with Haloperidol, Risperidone, or Thioridazine, Journal of Clinical Psychopharmacology, 22(2):174-182. 2002.

Potkin, SG, Anand, R, Alphs, L, Fleming, K. and the InterSePT Investigators: Neurocognitive Performance Does Not Correlate with Suicidaility in Schizophrenic and Schizoaffective Patients at Risk for Suicide, Schizophrenia Research, 1:59(1):59-66, 2002.

Potkin, SG, Anand, R, Hartman, R, Veach, J, Grossberg, G: Impact of Alzheimer’s Disease and Rivastigmine Treatment on Activities of Daily Living Over the Course of Mild to Moderately Severe Disease, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 26(4):713-720, 2002.

Potkin, S.G., Alva, G.A., Fleming, K., Anand, R., Keator, D., Carreon, D., Doo, M., Jin, Y., Wu, J.C., Fallon, J.H. Distinguishing Negative Symptom Schizophrenia with Positron Emission Tomography. American Journal of Psychiatry, 159(2):227-237, 2002.

Potkin SG, Basile VS, Jin Y, Masellis M, Badri F, Keator D, Wu JC, Alva G, Carreon DT, Bunney WE, Fallon JH, Kennedy JL: D1 Receptor Alleles Predict PET Metabolic Correlates of Clinical Response to Clozapine. Molecular Psychiatry, 8(1): 109-132, 2003.

Potkin SG, Anand R, Alphs L, Fleming K: Neurocognitive Performance Does Not Correlate with Suicidality in Schizophrenic and Schizoaffective Patients at Risk for Suicide. Schizophrenia Research, 59 (1):59-66, 2003.

Potkin SG, Thyrum PT, Bera R, Carreon D, Alva G, Kalali AH, Yeh C: Open-Label Study of the Effect of Combination Quetiapine/Lithium Therapy on Lithium Pharmacokinetics and Tolerability. Clinical Therapeutics, 24(11):1809-23, 2002.

Molnar M, Potkin SG, Bunney WE, Jones EG: MRNA Expression Patterns and Distribution of White Matter Neurons in Dorsolateral Prefrontal Cortex of Depressed Patients Differ from Those in Schizophrenia Patients. Biol Psychiatry, 1;53(1):39-47, 2003.

Meltzer HY, Alphs L, Green AI, Altamura AC, Anand R, Bertoldi A, Bourgeois M, Chouinard G, Islam MZ, Kane J, Krishnan R, Lindenmayer JP, Potkin S; International Suicide Prevention Trial Study Group: Clozapine Treatment for Suicidality in Schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry, 60(1): 82-91; 2003.

Fallon JH, Opole IO, Potkin SG: The Neuroanatomy of Schizophrenia: Circuitry and Neurotransmitter Systems. Clinical Neuroscience Research, 3(1-2):5-16, 2003.

Sivagnansundaram S, Muller DJ, Gubanov A, Potkin SG, Kennedy JL; Genetics of Schizophrenia: Current Strategies. Clinical Neuroscience Research, 3(1-2): 5-15, 2003.

Bunney BG, Bunney WE, Stein R, Potkin SG: Cortical Pathology in Schizophrenia: A Review of Data from the Dorsolateral Prefrontal Cortex. Current Opinion in Psychiatry, Vol. 16, Supplement 2, S9-S14,2003.

Roth BL, Douglas S, Potkin SG: Atypical Antipsychotic Drug Actions: Unitary or Multiple Mechanisms for “Atypicality”? Clinical Neuroscience Research, 3(1-2): 108-117, 2003.

Potkin SG, Saha AR, Kujawa MJ, Carson WH, Ali M, Stock E, Stringfellow J, Ingenito G, Marder SR: Aripiprazole, an Antipsychotic with a Novel Mechanism of Action, and Risperidone vs. Placebo in Patients with Schizophrenia and Schizoaffective Disorder. Archives of General Psychiatry, 60:681-690, 2003.

Keck PE Jr., Versiana M, Potkin SG, West SA, Giller E, Ice K, and the Ziprasidone in Mania Study Group: Ziprasidone in the Treatment of Acute Bipolar Mania: A Three Week, Placebo-Controlled, Double-Blind, Randomized Trial. American Journal of Psychiatry, 160:741-748, 2003.

Potkin SG, Alphs L, Hsu C, Krishnan R, Anand R, Young FK, Meltzer H, Green A: Predicting Suicidal Risk in Schizophrenic and Schizoaffective Patients in a Prospective 2 Year Trial. Biological Psychiatry, 54:444-452, 2003.

Fleming K, Kim S, Doo M, Maguire G, Potkin SG: Memory for Emotional Stimuli in Patients with Alzheimers Disease. American Journal of Alzheimer’s Disease and Other Dementias, 18(6):1-3, 2003.

Farlow M, Potkin SG, Koumaras B, Veach J, Mirski D: Analysis of Outcome in Retrieved Dropout Patients in a Rivastigmine vs Placebo, 26-Week, Alzheimer’s Disease Trial. Archives of Neurology, 60:843-848, 2003.

Alva G, Potkin SG: Alzheimer’s Disease and Other Dementias. Clinical Geriatric Medicine, 19(4):763-776, 2003.

Gauthier S, Emre M, Farlow MR, Bullock R, Grossberg GT, Potkin SG: Strategies for Continued Successful Treatment of Alzheimer’s Disease: Switching Cholinesterase Inhibitors. Current Medicine Research Opinion, 19(8):707-714, 2003.

Weiden PJ, Simpson GM, Potkin SG, O’Sullivan RL: Effectiveness of Switching to Ziprasidone for Stable but Symptomatic Outpatients with Schizophrenia. Journal of Clinical Psychiatry, 64(5):580-588, 2003.

Lee, HJ, Turner, JA, Potkin, S.G. (2004). Scalable parallel reconstruction algorithm for magnetic resonance images. Proceedings of the 2004 International Conference on Parallel and Distributed Processing Techniques and Applications (PDPTA ’04), Las Vegas, NV, Vol. 1, 73-79.

Lee, H.J., Potkin, S.G. (2004). Fine-grain parallel reconstruction algorithm for MR images. Proceedings of the 17th International Conference on Parallel and Distributed Computing Systems (PDCS ’04), San Francisco, CA, Vol. 1, 383-389.

Lee, H.J., Potkin, S.G., Lee, S. (2004). Intelligent Reconstruction Method of MR Images. Proceedings of 2004 International Symposium on Intelligent Signal Processing and Communication Systems, November 2004, Seoul Korea, 365-369.

Fallon JH, Keator DB, Mbogori J, Turner J, Potkin SG: Hostility Differentiates the Brain Metabolic Effects of Nicotine. Cognitive Brain Research, 18(2):142-148, 2004.

Harvey PD, Meltzer H, Simpson GM, Potkin SG, Loebel A, Siu C, Romano SJ: Improvement in Cognitive Function Following a Switch to Ziprasidone from Conventional Antipsychotics, Olanzapine, or Risperidone in Outpatients with Schizophrenia. Schizophrenia Research, 66(2-3):101-113, 2004.

Alphs L, Anand R, Islam MZ, Meltzer HY, Kane JM, Krisnan R, Green AI, Potkin SG, Chouinard G, Lindenmayer JP, Kerwin R: The International Suicide Prevention Trial (InterSePT): Rationale and Design of Suicidal Behavior in Schizophrenia and Schizoaffective Patients. Schizophrenic Bulletin, 30(3):577-586, 2004.

Potkin S. Butyrylcholinesterase: A Target in the Cholinergic Treatment of Alzheimer's Disease. Primary Care Psychiatry, 9:83-87 (2004).

Chattonpadhyay S, Xue B, Collins D, Pichika R, Bagnera R, Leslie FM, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J: Synthesis and Evaluation of Nicotine {alpha}4{beta}2 Receptor Radioligand, 5-(3’-18F-Fluoropropyl)-3-(2-(S)-Pyrrolidinylmethoxy) Pyridine, in Rodents and PET in Nonhuman Primate. Journal of Nuclear Medicine, 46(1):130-140, 2005.

Fallon J, Keator D, Mbogori J, Taylor D, Potkin SG: Gender: A Major Determinant of Brain Response to Nicotine. International Journal of Neuropsychopharmacology, 8(1): 17-26, 2005.

Tuszynski M, Thal L, Pay M, Salmon D, Sang H, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon JH, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J: A Phase I Clinical Trial of Nerve Growth Factor Gene Therapy for Alzheimer’s Disease. Nature Genetics, 11(5): 551-555, 2005

Hwang R, Shinkai T, Deluca V, Mueller DJ, Ni X, Macciardi F, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL: Association Study of 12 Polymorphisms Spanning the Dopamine D2 Receptor Gene and Clozapine Treatment Response in Two Treatment Refractory/Intolerant Populations. Psychopharmacology, (1):179-87, 2005.

Potkin S, Keck P Jr, Segal S, Ice K, English P: Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial. Journal of Clinical Psychopharmacology, 25 (4): 301-10, 2005.

Potkin S, Gharabawi G, Greenspan A, Rupnow M, Kosik-Gonzalez C, Remington G, Ruetsch C, Revicki D: Psychometric evaluation of the Readiness for Discharge Questionnaire. Schizophrenia Research, 80(2-3):203-12, 2005.

Jin Y, Potkin S, Kemp A, Huerta S, Alva G, Thai TM, Carreon D, Bunney W: Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ({alpha}TMS) on the Negative Symptoms of Schizophrenia. Schizophrenia Bulletin, e-published ahead of print, 2005.

Shinkai T, De Luca V, Hwang R, Matsumoto C, Hori H, Ohmori O, Remington G, Meltzer H, Lieberman J, Potkin S, Nakamura J, Kennedy J: Association study between a functional glutathione S-transferase (GSTP1) Gene Polymorphism (Ile105VAL) and Tardive Dyskinesia. Neuroscience Letters, 388 (2): 116-20, 2005.

Hwang R, Shinkai T, Deluca V, Macciardi F, Potkin S, Meltzer H, Kennedy J: Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment. European Neuropsychopharmacology, 16 (4): 248-259, 2006.

Keator, D; Gadde, S; Grethe, J ; Taylor, D; FIRST BIRN; Potkin, S. A General XML Schema and Associated SPM Toolbox for Storage and Retrieval of Neuro-Imaging Results and Anatomical Labels. Neuroinformatics 4(2), 2006.

Bose S, Mok A, Fallon J, Potkin S: Three-month change in cerebral glucose metabolism in patients with nonarteritic ischemic optic neuropathy. Graefe’s Archive for Clinical and Experimental Ophthalmology 13: 1-4, 2006.

Lane R, Potkin S, Enz A: Targeting acetylcholinesterase and butyrylcholinesterase in dementia. International Journal of Neuropsychopharmacology 9 (1): 101-24, 2006.

Turner JA, Smyth P, Macciardi F, Fallon JH, Kennedy JL, Potkin SG: Imaging phenotypes and genotypes in schizophrenia. Neuroinformatics 4(1): 21-49, 2006.

Potkin SG, Alva G, Gunay I, Koumaras B, Chen M, Mirski D: A pilot study evaluating the efficacy and safety of rivastigmine in patients with mixed dementia. Drugs Aging 23(3):241-9, 2006.

Mee S, Bunney BG, Reist C, Potkin SG, Bunney WE: Psychological Pain: A Review of Evidence. Journal of Psychiatric Research, 2006 Dec;40(8):680-90.

Peskind E, Potkin SG, Pomara N, Ott B, Olin J, Graham S, McDonald S for the Memantine Study Group: Memantine Treatment in Mild to Moderate Alzheimer Disease: A 24-Week Randomized Controlled Trial. The American Journal of Geriatric Psychiatry, 2006 Aug;14(8):704-15.

Potkin SG, Georges GM, Greenspan AJ, Mahmoud R, Kosik-Gonzalez C, Rupnow M, Bossie CY, Burtea V, Zhu Y, Trivedi JK: A Double-blind comparison of Risperidone, Quetiapine and Placebo in Patients with Schizophrenia Experiencing Acute Exacerbation Requiring Hospitalization. Schizophrenia Research, 2006 Jul;85(1-3):254-65.

Silver JM, Koumaras B, Chen M, Mirski D, Potkin SG, Reyes P, Warden D, Harvey PD, Arciniegas D, Katz D, Gunay I: The Effects of Rivastigmine on Cognitive Function in Patients with Traumatic Brain Injury. Neurology, 2006 Sep 12;67(5):748-55.

Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, Narayanan TK, Potkin SF, Mukherjee J: Nicotinic alpha4beta2 receptor imaging agents Part II. Synthesis and biological evaluation of 2-[(18)F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ((18)F-nifene) in rodents and imaging by PET in nonhuman primate. Nuclear Medicine and Biology, 33(3):295-304, 2006.

Jin Y, O’Halloran JP, Plon L, Sandman JP, Potkin SG: Alpha EEG predicts visual reaction time. International Journal of Neuroscience, 116(9): 1035-1044, 2006.

Saigal N, Pichika R, Easwaramoorthy B, Collins D, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J: Synthesis and biological evaluation of a novel serotonin 5-HT1a receptor radioligand, 18F-Mefway in rodents and imaging by PET in non-human primate. Journal of Nuclear Medicine, 47(10), 2006.

Hwang R, Shinkai T, De Luca V, Ni X, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL. Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. Nov 8 2006

Hwang R, Shinkai T, DeLuca V, Ni X, Potkin SG, Lieberman JA, Meltzer H: Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. Journal of Psychopharmacology, 2007 Sep;21(7):718-27.

Feldman HH, Ferris S, Winblad B, Sfikas N, Mancione L, He Y, Tekin S, Burns A, Cummings J, del Ser T, Inzitari D, Orgogozo JM, Sauer H, Scheltens P, Scarpini E, Herrmann N, Farlow M, Potkin S, Charles HC, Fox NC, Lane R. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol. ;6(6):501-12, 2007

Zai CC, Hwang RW, De Luca V, Müller DJ, King N, Zai GC, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL.Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients. Int J Neuropsychopharmacol. 10(5):639-51, 2007

Easwaramoorthy, B., Pichika, R., Collins, D., Potkin, S.G., Leslie, F.M. and Mukherjee, J.: Effect of acetylcholinesterase inhibitors on nicotinic a4b2 receptor PET radiotracer, 18F-Nifene: A measure of acetylcholine competition. Synapse. 2007 Jan;61(1):29-36.

Friedman L, Stern H, Brown GG, Mathalon DH, Turner J, Glover GH, Gollub RL, Lauriello J, Lim KO, Cannon T, Greve DN, Bockholt HJ, Belger A, Mueller B, Doty MJ, He J, Wells W, Smyth P, Pieper S, Kim S, Kubicki M, Vangel M, Potkin SG. Test-retest and between-site reliability in a multicenter fMRI study. Hum Brain Mapp. Jul 17, 2007

Atz M, Walsh D, Cartagena P, Li J, Evans S, Choudary P, Overman K, Stein R, Tomita H, Potkin S, Myers R, Watson SJ, Jones EG, Akil H, Bunney WE Jr, Vawter MP; Members of National Institute of Mental Health Conte Center and Pritzker Neuropsychiatric Disorders Research Consortium. Methodological considerations for gene expression profiling of human brain. J Neurosci Methods.163(2):295-309, 2007

Potkin, SG, Cohen, M, Panagides, J Efficacy and Tolerability of Asenapine in Acute Schizophrenia: A Placebo- and Risperidone-Controlled Trial, J Clin Psychiatry, 68(10):1492-500, 2007.

Loebel AD, Khanna S, Rajadhyaksha S, Siu CO, Giller E, Potkin SG. Ziprasidone in treatment-resistant schizophrenia: a 52-week, open-label continuation study. J Clin Psychiatry. 68(9):1333-8, 2007

Gehricke JG, Loughlin SE, Whalen CK, Potkin SG, Fallon JH, Jamner LD, Belluzzi JD, Leslie FM. Smoking to self-medicate attentional and emotional dysfunctions. Nicotine Tob Res. 2007 Nov;9 Suppl 4:S523-36. Review.

Potkin, SG, Litman R, Torres R, Wolfgang CD. Efficacy of Iloperidone in the Treatment of Schizophrenia: Initial Phase 3 Studies. J of Clin Psychopharmacology, 28(2 Suppl1):S4-11, 2008

Bunney JN, Potkin SG.Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br Med Bull. 86:23-32, 2008

Potkin SG. New advances in the treatment of schizophrenia. Introduction. J Clin Psychopharmacol. 28(2 Suppl 1):S1-3, 2008.

Tura E, Turner JA, Fallon JH, Kennedy JL, Potkin SG. Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia. Neuroreport 19(6):603-7,2008.

Friedman L, Turner JA, Stern H, Mathalon DH, Trondsen LC, Potkin SG. Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls. Neuroimage 40(3):1181-94, 2008.

Kemp AS, Schooler NR, Kalali AH, Alphs L, Anand R, Awad G, Davidson M, Dubé S, Ereshefsky L, Gharabawi G, Leon AC, Lepine JP, Potkin SG, Vermeulen A. What Is Causing the Reduced Drug-Placebo Difference in Recent Schizophrenia Clinical Trials and What Can be Done About It? Schizophr Bull. 2008 Aug 22.

Zai CC, Romano-Silva MA, Hwang R, Zai GC, Deluca V, Müller DJ, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia. Schizophr Res. 2008 Dec;106(2-3):248-52.

Ford JM, Roach BJ, Jorgensen KW, Turner JA, Brown GG, Notestine R, Bischoff-Grethe A, Greve D, Wible C, Lauriello J, Belger A, Mueller BA, Calhoun V, Preda A, Keator D, O'Leary DS, Lim KO, Glover G, Potkin SG; FBIRN, Mathalon DH. Tuning in to the voices: a multisite FMRI study of auditory hallucinations. Schizophr Bull. 2009 Jan;35(1):58-66.

Wible CG, Lee K, Molina I, Hashimoto R, Preus AP, Roach BJ, Ford JM, Mathalon DH, McCarthey G, Turner JA, Potkin SG, O'Leary D, Belger A, Diaz M, Voyvodic J, Brown GG, Notestine R, Greve D, Lauriello J; FBIRN. fMRI Activity Correlated With Auditory Hallucinations During Performance of a Working Memory Task: Data From the FBIRN Consortium Study. Schizophr Bull. 2009 Jan;35(1):47-57.

Potkin SG, Ford JM. Widespread Cortical Dysfunction in Schizophrenia: The FBIRN Imaging Consortium. Schizophr Bull. 2009 Jan;35(1):15-8.

Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, Nguyen DD, Mathalon D, Ford J, Lauriello J, Macciardi F; FBIRN. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull. 2009 35(1):96-108.

Brown GG, McCarthy G, Bischoff-Grethe A, Ozyurt B, Greve D, Potkin SG, Turner JA, Notestine R, Calhoun VD, Ford JM, Mathalon D, Manoach DS, Gadde S, Glover GH, Wible CG, Belger A, Gollub RL, Lauriello J, O'Leary D, Lim KO. Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophr Bull. 2009 Jan;35(1):32-46.

Potkin SG, Turner JA, Brown GG, McCarthy G, Greve DN, Glover GH, Manoach DS, Belger A, Diaz M, Wible CG, Ford JM, Mathalon DH, Gollub R, Lauriello J, O'Leary D, van Erp TG, Toga AW, Preda A, Lim KO; FBIRN. Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study. Schizophr Bull. 2009 35(1):19-31.

Kim DI, Mathalon DH, Ford JM, Mannell M, Turner JA, Brown GG, Belger A, Gollub R, Lauriello J, Wible C, O'Leary D, Lim K, Toga A, Potkin SG, Birn F, Calhoun VD. Auditory Oddball Deficits in Schizophrenia: An Independent Component Analysis of the fMRI Multisite Function BIRN Study. Schizophr Bull. 2009 Jan;35(1):67-81.

Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, Macciardi F. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol Psych, (2009) 14, 416–428.

Potkin SG, Weiden PJ, Loebel AD, Warrington LE, Watsky EJ, Siu CO. Remission in schizophrenia: 196-week, double-blind treatment with ziprasidone vs. haloperidol. Int J Neuropsychopharmacol. 2009 M7:1-16.

Gehricke JG, Potkin SG, Leslie FM, Loughlin SE, Whalen CK, Jamner LD, Mbogori J, Fallon JH. Nicotine-induced brain metabolism associated with anger provocation. Behav Brain Funct. 2009 24;5(1):19.

Wu JC, Kelsoe JR, Schachat C, Bunney BG, Demodena A, Golshan S, Gillin JC, Potkin SG, Bunney WE. Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder. Biol Psychiatry. 2009 Aug 1;66(3):298-301. Epub 2009 Apr 9..

De Luca V, Souza RP, Viggiano E, Zai CC, Shinkai T, Lieberman JA, Potkin SG, Meltzer HY, Remington G, Kennedy JL. MDR1 gene in tardive dyskinesia scale scores: Comparison of strategies for quantitative trait haplotype analysis. Schizophr Res. 2009 110(1-3):200-1.

Zai CC, Tiwari AK, Basile V, De Luca V, Müller DJ, King N, Voineskos AN, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL. Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients. Pharmacogenomics J. 2009 Jun;9(3):168-74. Epub 2009 Feb 24..

Zai CC, Tiwari AK, De Luca V, Müller DJ, Bulgin N, Hwang R, Zai GC, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia. Eur Neuropsychopharmacol. 2009 19(5):317-28.

Silver JM, Koumaras B, Meng X, Potkin SG, Reyes PF, Harvey PD, Katz DI, Gunay I, Arciniegas DB. Long-term effects of rivastigmine capsules in patients with traumatic brain injury. Brain Inj. 2009 Feb;23(2):123-32.

Volpi S, Potkin SG, Malhotra AK, Licamele L, Lavedan C: Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. Journal of Clinical Psychiatry, 2009 Jun;70(6):801-9.

Potkin SG, Turner JA, Guffanti G, Lakatos A, Torri F, Keator DB, Macciardi F: Genome-wide Strategies for Discovering Genetic Influences on Cognition and Cognitive Disorders: Methodological Considerations. Cognitive Neuropsychiatry, 2009 Jul;14(4):391-418.

Kim DI, Manoach DS, Mathalon DH, Turner JA, Mannell M, Brown GG, Ford JM, Gollub RL, White T, Wible C, Belger A, Bockholt HJ, Clark VP, Lauriello J, O'Leary D, Mueller BA, Lim KO, Andreasen N, Potkin SG, Calhoun VD. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum Brain Mapp. 2009 Nov;30(11):3795-811.

Zai CC, Tiwari AK, Basile V, de Luca V, Müller DJ, Voineskos AN, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL. Oxidative stress in tardive dyskinesia: Genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes. ProgNeuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):50-6. Epub 2009 Sep 22.

Potkin SG, Siu CO. Dropouts and missing data in psychiatric clinical trials. Letter to Editor Am J Psychiatry. 2009 Nov;166(11):1295

Holland D, Brewer JB, Hagler DJ, ... Potkin SG, ... Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20954-20959.

Hwang R, Zai C, Tiwari A, Müller DJ, Arranz MJ, Morris AG, McKenna PJ, Munro J, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010 Jun;10(3):200-18. Epub 2009 Dec 22.

Shen, L, Kim, S, Risacher, S, Nho, K,Swaminathan, S, West, JD, Foroud, T, Pankratz, N, Moore, JH, Sloan, CD, Huentelman, MJ, Craig, DW, DeChairo, BM, Potkin, SG, Jack Jr, CR, Weiner, MW, Saykin, AJ, Alzheimer’s Disease Neuroimaging Initiative. Whole genome association study of brain-wide imaging ohenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort, Neuroimage 2010 15:53(3):1051-63. Epub 2010 Jan 25.

Potkin SG, Guffanti G, Lakatos A, Turner JA, Kruggel F, Fallon JH, Saykin AJ, Orro A, Lupoli S, Salvi E, Weiner M, Macciardi F; Alzheimer's Disease Neuroimaging Initiative. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS One. 2009 7;4(8):e6501.

Novak G, Gallo A, Zai CC, Meltzer HY, Lieberman JA, Potkin SG, Voineskos AN, Remington G, Kennedy JL, Levesque D, Le Foll B. Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. Psychiatr Genet. 2010;20(1):39-43.

Stein JL, Hua X , Lee S,. Ho AJ, Leow AD, Toga AW, Saykin AJ,
Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW,. Gerber JD,
Allen AN, Corneveaux JJ, DeChairo BM Potkin SG Weiner MW, Thompson PM Voxelwise genome-wide association study (vGWAS), Neuroimage. 2010 15;53(3):1160-74.

Stein JL, Hua X , Morra JH, Lee S,. Hibar, DP, Ho AJ, Leow AD, Toga AW, Sul JH, Kang HM, Eskin, E, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW,. Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, Webster J, DeChairo BM Potkin SG, Jack C, Weiner MW, Thompson PM Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease, Neuroimage. 2010 Jun;51(2):542-54.

Lakatos A, Derbeneva O, Younes D, Keator D, Bakken T, Lvova M, Brandon M, Guffanti G, Reglodi D, Saykin A, Weiner M, Macciardi F, Schork N, Wallace DC, Steven G. Potkin, and the Alzheimer’s Disease Neuroimaging Initiative, Association between Mitochondrial DNA variations and Alzheimer's Disease in the ADNI cohort, Neurobiol Aging. 2010 31(8):1355-63.

DeBattista C, Kinrys, G Goldstein C, Zajecka J, Kocsis JH, Teicher M, Potkin SG, Preda A, Multani G, Brandt LJ, Schiller M, Iosifescu D, Fava M, Hoffman DA, Efficacy of Referenced-EEG (rEEG) in Guiding Medication Selection for the Treatment of Depression Journal of Psychiatric Research, in press.

Stahl SM, Malla A, Newcomer JW, Potkin SG, Weiden, PJ, Harvey, PD, Loebel A, Watsky E, Siu CO, Romano S. A Post Hoc Analysis of Negative Symptoms and Psychosocial Function in Patients With Schizophrenia: A 40-Week Randomized, Double-Blind Study of Ziprasidone Versus Haloperidol Followed by a 3-Year Double-Blind Extension Trial. Journal of Clinical Psychopharmacology. 2010 ;30(4):425-30.

Kim MA, Tura E, Potkin SG, Fallon JH, Manoach DS, Calhoun VD; FBIRN, Turner JA. Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation. Schizophr Res. 2010 117(1):42-51.

Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, Dinov ID, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, DeCarli CS, DeChairo BM, Potkin SG, Jack CR Jr, Weiner MW, Raji CA, Lopez OL, Becker JT, Carmichael OT, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010 4;107(18):8404-9. Epub 2010 Apr 19.

Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR Jr, Weiner MW; Alzheimer's Disease Neuroimaging Initiative. Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement. 2010;6(3):265-73.

Zai CC, Tiwari AK, Muller DJ, De Luca V, Shinkai T, Shaikh S, Ni X, Sibony D, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL. The catehol-O-methyl-transferase gene in tardive dyskinesia. World J Biol Psychiatry. 2010 Sep;11(6):803-12.

Kane JM, Potkin SG, Daniel DG, Buckley PF. A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia. J Clin Psychiatry. 2010 Jul 27. [Epub ahead of print] doi:10.4088/jcp.07m03733yel.

Potkin SG, Preda A, Kalali AH, Harvey PD. Using new antipsychotics in your clinical practice. J Clin Psychiatry. 2010 Oct;71(10):e101.

Brown GG, Mathalon DH, Stern H, Ford J, Mueller B, Greve DN, McCarthy G, Voyvodic J, Glover G, Diaz M, Yetter E, Ozyurt IB, Jorgensen KW, Wible CG, Turner JA, Thompson WK, Potkin SG; Function Biomedical Informatics Research Network. Multisite reliability of cognitive BOLD data. Neuroimage. 2010 Oct 13. [Epub ahead of print] doi:10.1016/j.neuroimage.2010.09.076.

Potkin SG, Macciardi F, Vawter, M, Guffanti G, Wang Q, Turner, JA, Lakatos A, Miles M, Lander A, Xie X, Identifying Gene Regulatory networks in Schizophrenia, Neuroimage. 2010 15;53(3):839-47.
   
Professional
Societies
American Psychiatric Association
Society of Biological Psychiatry
American Association for the Advancement of Science
Collegium Internationale Neuro-Psychopharmacologicum
Psychiatric Research Society
West Coast College of Biological Psychiatry
Winter Conference on Brain Research
American Foundation for Suicide Prevention
International College of Geriatric Psychopharmacology
American College of Neuropsychopharmacology
International Society for CNS Clinical Trials and Methodolog
Society for Neuroscience
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=3170
   
Last updated 01/13/2011