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Luis M. de la Maza

Professor, Pathology
School of Medicine

Director, Division of Medical Microbiology


M.D., Facultad de Medicina (Spain), 1966


Ph.D.,, University of Minnesota, 1974

Phone: (949) 824-7450
Fax: (949) 824-2160
Email: lmdelama@uci.edu

University of California, Irvine
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-4800

picture of Luis M. de la Maza

Research
Interests
Chlamydia trachomatis. Vaccines. Sexually transmitted diseases. Diagnostic Medical Microbiology
   
URL www.ucihs.uci.edu/com/pathology/faculty/delamaza.html
   
Research
Abstract
Currently attempts are being made to vaccinate experimental animals with the purified major outer membrane protein (MOMP) of the C. trachomatis mouse pneumonitis biovar. Antibodies to this protein have been shown to occur in a majority of chlamydial infections and furthermore polyclonal and monoclonal antibodies to the MOMP are known to neutralize chlamydial infectivity in vitro. In the animal model mice will be inoculated with the purified MOMP and then they will be challenged with infectious Chlamydiae in the genital tract. The ability of the vaccine to prevent infection and/or to preserve fertility will be determined.
   
Publications Most Recent Publications
   
  Cruz-Fisher, M. I., C. Cheng, G. Sun, S. Pal, A. Teng, D. M. Molina, M. A. Kayala, A. Vigil, P. Baldi, P. L. Felgner, X. Liang and L. M. de la Maza. Identification of immunodominant antigens by probing a whole Chlamydia ORFome microarray using sera from immunized mice. Infect. Immun. Jan. 2011 (in press)
   
  Cheng, C., M. I. Cruz-Fisher, D. Tifrea, S. Pal, B. Wizel and L. M. de la Maza. Induction of protection in mice against a respiratory challenge by a vaccine formulated with the Chlamydia major outer membrane protein adjuvanted with IC31. Vaccine (in press).
   
  Ralli-Jain, P., D. Tifrea, C. Cheng, S. Pal and L. M. de la Maza. Enhancement of the protective efficacy of a Chlamydia trachomatis recombinant vaccine by combining systemic and mucosal routes for immunization. Vaccine 28:7659-7666, 2010.
   
  Pal, S., A. K. Sarcon and L. M. de la Maza. A new murine model for testing vaccines against genital Chlamydia trachomatis infections in males. Vaccine 28:7606-7612, 2010.
   
  Chu, H., A. Slepenkin, M. Elofsson, P. Keyser, L. M. de la Maza and E. M. Peterson. Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseria gonorrhoeae. Int. J. Antimicrob. Agents 36:145-150, 2010.
   
  Pal, S., O. Tatarenkova and L. M. de la Maza. Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge. J. Reprod. Immunol. 2010.
   
  Molina, D. M., S. Pal, M. A. Kayala, A. Teng, P. J. Kim, P. Baldi, P. L. Felgner, X. Liang and L. M. de la Maza. Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays. Vaccine 28:3014-3024, 2009.
   
  Pal, S, A. K. Sarcon and L. M. de la Maza. C3H male mice with severe combined immunodeficiency cannot clear a urethral infection with a human serovar of Chlamydia trachomatis. Infect. Immun. 77:5602-5607, 2009.
   
  Cheng, C., I. Bettahi, M. I. Cruz-Fisher, S. Pal, P. Jain, Z. Jia, J. Holmgren, A. M. Harandi, and L. M. de la Maza. Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin. Vaccine 27:6239-6246, 2009.
   
  Sun, G., S. Pal, J. Weiland, E. M. Peterson, and L. M. de la Maza. Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein. Vaccine 27:5020-5025, 2009.
   
  Pal, S., J. Bravo, E. M. Peterson, and L. M. de la Maza. Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Infect. Immun. 76:5581-5587, 2008.
   
  Matheu, M. P., C. Beeton, A. Garcia, V. Chi, S. Rangaraju, O. Safrina, K. Monaghan, M. L. Uemura, D. Li, S. Pal, L. M. de la Maza, E. Monuki, A. Flugel, M. W. Pennington, I. Parker, K. G. Chandy, and M. D. Cahalan. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity 29:602-614, 2008.
   
  Cai, S., F. He, H. S. Samra, L. M. de la Maza, M. E. Botazzi, S. B. Joshi, and C. R. Middaugh. Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Mol. Pharm. 6:1553-1561, 2009.
   
Professional
Societies
American Society for Advancement of Science
American Society of Clinical Pathologists
American Society for Microbiology
American Association for Investigative Pathology
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2972
   
Last updated 12/09/2010