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Thomas Poulos

Chancellor's Professor of Biochemistry, Chemistry, and Pharmaceutical Sciences


PH.D., University of California, San Diego, 1972, Biology

Phone: (949)824-7020 lab: 4322
Fax: (949) 824-3280
Email: poulos@uci.edu

University of California, Irvine
2206 Natural Sciences 1
Mail Code: 3900
Irvine, CA 92697

picture of Thomas  Poulos

Research
Interests
Protein crystallography, protein engineering, heme enzyme structure and function.
   
URL Poulos Lab Web Site
   
Academic
Distinctions
Presidential Meritorious Service Award, Univ. Maryland 1991;
Chancellor's Professor, UCI 2000
Brodie Award for Drug Metabolism Amer. Soc. of Pharmacology and Experimental Therapeutics, 2004

Appointments:
Research Scientist UCSD Dept. Chemistry from 1973-1983;
Principal Res. Scientist at Genex Corp. from 1983-1984;
Director of Protein Engineering at Genex Corp. from 1984-1987;
Director for the Univ. of Maryland's Center for Advanced Res. in Biotehcnology and Professor of Chemistry, Univ. of Maryland, College Park from 1987-1991;
Professor at UCI since 1992.
   
Publications Madrona Y, Hollingsworth SA, Khan B, Poulos TL (2013). P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry 52, 5039-5050
   
  Sevrioukova IF, Poulos TL (2013) Dissecting Cytochrome P450 3A4-ligand interactions using ritonavir analogues. Biochemistry 52, 4474-4481.
   
  Sevrioukova IF, Poulos TL (2013). Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. J. Med. Chem. 9, 3733-3741.
   
  Tripathi S, Li H, Poulos TL (2013). Structural basis for effector control and redox partner recognition in cytochrome P450. Science 340, 1227-1230.
   
  Li H, Jamal J, Chreifi G, Venkatesh V, Abou-Ziab H, Poulos TL. (2013). Dissecting the Kinetics of the NADP+ - FADH2 Charge Transfer Complex and Flavin Semiquinones in Neuronal Nitric Oxide Synthase. J. Inorg. Biochem. 124, 1-10.
   
  Jasion VS, Poulos TL (2012). Leishmania major peroxidase is a cytochrome c peroxidase. Biochemistry 51, 2453-2460
   
  Sevrioukova IF, Poulos TL (2012) Interaction of human P4503A4 with ritonavir analogs. Arch. Biochem. Biophys. 520, 108-116
   
  Publications from Pubmed
   
Professional
Societies
Protein Society
American Chemical Society
Ameican Crystallographic Association
Biophysical Society
Amer. Society of Pharmacology and Experimental Therapeutics
   
Graduate Programs Chemical Biology

Medicinal Chemistry and Pharmacology

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2699
   
Last updated 01/09/2014