Thomas Poulos

Chancellor's Professor of Biochemistry, Chemistry, and Pharmaceutical Sciences

PH.D., University of California, San Diego, 1972, Biology

Phone: (949)824-7020 lab: 4322
Fax: (949) 824-3280

University of California, Irvine
2206 Natural Sciences 1
Mail Code: 3900
Irvine, CA 92697

picture of Thomas  Poulos

Protein crystallography, protein engineering, heme enzyme structure and function.
URL Poulos Lab Web Site
Presidential Meritorious Service Award, Univ. Maryland 1991;
Chancellor's Professor, UCI 2000
Brodie Award for Drug Metabolism Amer. Soc. of Pharmacology and Experimental Therapeutics, 2004

Research Scientist UCSD Dept. Chemistry from 1973-1983;
Principal Res. Scientist at Genex Corp. from 1983-1984;
Director of Protein Engineering at Genex Corp. from 1984-1987;
Director for the Univ. of Maryland's Center for Advanced Res. in Biotehcnology and Professor of Chemistry, Univ. of Maryland, College Park from 1987-1991;
Professor at UCI since 1992.
Available Technologies
Publications Madrona Y, Hollingsworth SA, Khan B, Poulos TL (2013). P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry 52, 5039-5050
  Sevrioukova IF, Poulos TL (2013) Dissecting Cytochrome P450 3A4-ligand interactions using ritonavir analogues. Biochemistry 52, 4474-4481.
  Sevrioukova IF, Poulos TL (2013). Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. J. Med. Chem. 9, 3733-3741.
  Tripathi S, Li H, Poulos TL (2013). Structural basis for effector control and redox partner recognition in cytochrome P450. Science 340, 1227-1230.
  Li H, Jamal J, Chreifi G, Venkatesh V, Abou-Ziab H, Poulos TL. (2013). Dissecting the Kinetics of the NADP+ - FADH2 Charge Transfer Complex and Flavin Semiquinones in Neuronal Nitric Oxide Synthase. J. Inorg. Biochem. 124, 1-10.
  Jasion VS, Poulos TL (2012). Leishmania major peroxidase is a cytochrome c peroxidase. Biochemistry 51, 2453-2460
  Sevrioukova IF, Poulos TL (2012) Interaction of human P4503A4 with ritonavir analogs. Arch. Biochem. Biophys. 520, 108-116
  Publications from Pubmed
Protein Society
American Chemical Society
Ameican Crystallographic Association
Biophysical Society
Amer. Society of Pharmacology and Experimental Therapeutics
Graduate Programs Chemical Biology

Medicinal Chemistry and Pharmacology

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Last updated 01/09/2014