Christopher C.W. Hughes

Professor & Chair, Molecular Biology and Biochemistry
School of Biological Sciences

Professor, Biomedical Engineering
The Henry Samueli School of Engineering

B.Sc (Hon)., University of London, 1981, Biochemistry


Ph.D., University of London, 1988

Phone: (949)824-8771
Fax: (949) 824-8551
Email: cchughes@uci.edu

University of California, Irvine
Dept. Mol. Biol. & Biochem.
3219 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697

picture of Christopher C.W. Hughes

Research
Interests
Blood vessel development, angiogenesis in cancer, bioengineering of blood vessels and tissues
   
URL Hughes Lab Website
   
Research
Abstract
Growth of new blood vessels (angiogenesis) is an important process both in the healthy individual and in disease. Angiogenesis is becoming a hot area of research for cancer biologists as recent data suggest that blocking new blood vessel growth can slow tumor growth by cutting off the supply of oxygen and nutrients.

We have identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes.

In collaboration with Dr. Steven George we are developing multi-cellular 3D tissues for high-throughput drug screening (HTS). In addition we are using tissue engineering to create pre-vascularized thick tissues suitable for transplantation and tissue repair.

For more information see our website: http://darwin.bio.uci.edu/~cchughes/

Patents:
Doubly chimeric human T cell-microvessel SCID mice: a small animal model of human allograft rejection

Keywords: Endothelial, vascular, angiogenesis, tissue engineering, high-throughput drug screening (HTS), 3D-tissues, tumor microenvironment
   
Available Technologies
Publications Selected from > 70 (h-index = 44)
   
  Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, and Hughes CCW. 2013. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterio. Thromb. Vasc. Biol. (in revision)
   
  Welch-Reardon KM, Ehsan SM, Wang K, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CCW. 2013 Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2). Arterio. Thromb. Vasc. Biol. (in revision)
   
  Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CCW, and George SC. 2013. A three-dimensional in vitro model of tumor angiogenesis and intravasation. Integrative Biology (in revision)
   
  Heylman C, Sobrino A, Shirure VS, Hughes CCW, and George SC 2013. A strategy for integrating essential 3D microphysiological systems of human organs for realistic anti-cancer drug screening. Exp. Biol. Med. (in revision)
   
  Hsu YH, Moya ML, Hughes CCW, George SC and Lee AP. 2013 microfluidic platform for generating large-scale nearly identical human microphysiological system arrays. Lab on a Chip 13: 2990-2998
   
  Moya ML, Hsu, YH, Lee AP, Hughes CCW, and George SC. 2013. In vitro perfused human capillaries. Tissue Engineering 19: 730-737
   
  Gong J, Archer R, Brown M, Fisher S, Chang C, Peacock MR, Hughes CCW, Freimark B. 2013 Measuring response to therapy by near-infrared imaging of tumors using a phosphatidylserine-targeting antibody fragment. Mol. Imaging 12: 244-56
   
  Newman AC and Hughes CCW. 2012. Macrophages and angiogenesis: A role for wnt signaling. Vasc. Cell 4: 13-27
   
  Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Gershon PD, and Hughes CCW. 2012. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived HGF and fibronectin in angiogenesis. Arterioscler. Thromb. Vasc. Biol. 33: 513-22.
   
  Hsu YH, Moya ML, Abiri P, Hughes CCW, George SC, and Lee AP. 2012. Full range physiological mass transport control in 3D tissue cultures. Lab on a Chip 13: 81-89
   
  White SM, Hingorania R, Aroraa R, Hughes CCW, George SC, and Choi B. 2012. Longitudinal in vivo imaging to assess vascularization of implantable engineered tissues. Tissue Eng. 18: 697-709
   
  Kim J-H, George SC, and Hughes CCW. 2012. BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis 15: 497-509
   
  Newman AC, Nakatsu MN, Chou W, Gershon PD, and Hughes CCW. 2011 The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Molecular Biology of the Cell. 22: 3791-800
   
  Mestas J, and Hughes CCW. 2004. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172: 2731-2738
   
Grant PI on two NIH RO1s. PI on an NIH R21. Co-I on an RO1, and a UH2
   
Professional
Societies
North American Vascular Biology Organization
American Society for Investigative Pathology
   
Graduate Programs Cancer Biology

Biotechnology

Biomedical Engineering

   
Research Centers Cancer Research Institute
   
Edwards Lifesciences Center for Advanced Cardiovascular Technology
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2498
   
Last updated 02/08/2016