Anne L. Calof

Associate Professor, Anatomy & Neurobiology
School of Medicine

Associate Professor (joint appointment), Developmental & Cell Biology
School of Biological Sciences

B.A., Reed College, Portland, Oregon


Ph.D., Univ. of Calif., San Francisco, School of Medicine

Phone: (949) 824-4616, 5745
Fax: (949) 824-1104
Email: alcalof@uci.edu

University of California, Irvine
Dept. of Anatomy & Neurobiology
5234 Bio Sci II
Mail Code: 1275
Irvine, CA 92697


Research
Interests
Molecular mechanisms of neurogenesis, neuronal differentiation, and cell death
   
URL www.ucihs.uci.edu/anatomy/calofres.html
   
Academic
Distinctions
1978 Phi Beta Kappa, Reed College Chapter
1978-1981 Graduate Fellowship, National Science Foundation
1981-1982 Graduate Opportunity Fellowship, University of California
1988 Postdoctoral Fellowship, Muscular Dystrophy Association
1989-1990 Postdoctoral Fellowship, National Institutes of Health NRSA
1993-1996 Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation
   
Appointments 1985-1987 Postdoctoral Associate
Columbia Univ. CP & S, New York, NY
1987 Assistant Instructor
Molecular Embryology of the Mouse course
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
1987-1990 Postdoctoral Research Associate/Instructor
Tufts Univ. Sch. Med., Boston, MA
1991-1995 Assistant Professor
Department of Biological Sciences
University of Iowa, Iowa City, IA
1995-1996 Assistant Professor
Department of Anatomy & Neurobiology
and the Developmental Biology Center
Univ. Calif., Irvine, Coll. of Med., Irvine, CA
1996-present Associate Professor
Department of Anatomy & Neurobiology
and the Developmental Biology Center
Univ. Calif., Irvine, Coll. of Med., Irvine, CA
   
Research
Abstract
Understanding the basic biology of neuron production is of fundamental importance if we are to understand the origins of developmental disabilities of the nervous system. The production of most neurons takes place during embryonic development, rapidly at first, then more slowly, and in most cases permanently ceases around the time of birth. How does the developing nervous system know when and where to produce neurons, and when to stop producing them? Signals that promote and then halt neuron production at the correct times and in the correct locations must exist to ensure that the proper form of the nervous system is attained. However, misregulation of stimulatory signals may result in unchecked growth and neural cancers, and persistence of the developmental signal that says "stop making neurons" may account for the fact that neurons cannot be regenerated when their numbers have been reduced by developmental defects, injury, or aging.

My laboratory's research efforts are concentrated on understanding the nature and the targets of the signals that regulate the production of neurons by neuronal progenitor cells, during development and regeneration of the nervous system. To study these issues, we concentrate primarily on one system, in which the behavior of neuronal progenitor cells can be observed and manipulated easily: the olfactory epithelium (OE) of the mouse. We study the molecular regulation of neurogenesis and neuronal regeneration using a variety of approaches, including tissue culture, molecular biology , and the generation and analysis of transgenic mice.
Among the questions we are asking, using these approaches, are the following:
How many distinct cell stages are there in neuronal lineages?
What molecules control the proliferation of neuronal progenitor cells?
Among what cells does one find the self-renewing neuronal stem cell that must exist in the OE to permit neuron production throughout life?
Where do genes important for neurogenesis act in these developmental pathways?
What molecules control the survival of neurons in the OE? And what signals cause the OE to upregulate the production of new neurons when existing neurons are killed?
How are the opposing effects of pro- and anti-neurogenic factors integrated at the tissue level to maintain proper neuron number?
   
Publications Shou J., Murray R.C., Rim P.C., and Calof A.L. Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage. Development, 2000;127 (24):5403-5413.
   
  Murray R.C., Tapscott S.J., Petersen J.W., Calof A.L., and McCormick M.B. A fragment of the Neurogenin1 gene confers regulated expression of a reporter gene in vitro and in vivo. Developmental Dynamics, (2000) 218: 189-194.
   
  Murray R.C. and Calof A.L. Neuronal regeneration: Lessons from the olfactory system. Seminars in Cell Dev Biol, (1999) Aug;10(4):421-431.
   
  Shou J., Rim P.C., Calof A.L. BMPs inhibit neurogenesis by a mechanism involving degradation of transcription factor. Nature Neuroscience, (1999) Apr;2(4):339-45.
   
  Calof A.L., Rim P.C., Askins K.J., Mumm J.S., Gordon M.K., Iannuzzelli P., Shou J. Factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium. Ann N Y Acad Sci. (1998) Nov 30;855:226-9.
   
  Calof A.L., Mumm J.S., Rim P.C., Shou J. The neuronal stem cell of olfactory epithelium. Journal of Neurobiology, (1998) Aug;36(2):190-205. Review.
   
  Calof, A.L., Rim, P.C, Askins, K,J., Mumm, J.S.,
Gordon, M.K., Iannuzzelli, P., and Shou, J. Factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium. In: Olfaction and Taste XII (C. Greer and C. Murphy, eds.), (1997) New York, Annals of the New York Academy of Sciences, In press.
   
  Mumm J.S., Shou J., Calof A.L. Colony-forming progenitors from mouse olfactory epithelium: evidence for feedback regulation of neuron production. Proceedings of the National Academy of Sciences, USA,
(1996) Oct 1;93(20):11167-72.
   
  Calof A.L., Hagiwara N., Holcomb J.D., Mumm J.S., Shou J. Neurogenesis and cell death in olfactory epithelium.
Journal of Neurobiology, (1996) May;30(1):67-81. Review.
   
  Calof A.L., Holcomb J.D., Mumm J.S., Haglwara N., Tran P., Smith K.M., Shelton D. Factors affecting neuronal birth and death in the mammalian olfactory epithelium. Ciba Found Symp. (1996)196:188-205; discussion; 205-10. Review.
   
Professional
Societies
Society for Neuroscience Chair, Chapters Committee, 1998-2002 Association for Chemoreception Sciences
Society for Developmental Biology
American Society for Cell Biology
   
Graduate Programs Developmental Biology and Genetics

Neurobiology

   
Research Center Developmental Biology Center
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2420
   
Last updated 03/15/2002