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Bruce J. Tromberg

Professor, College of Medicine, Biomedical Engineering
The Henry Samueli School of Engineering

Director, Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic
School of Medicine

Director, Beckman Laser Institute


B.A., Vanderbilt University, Chemistry


Ph.D., Chemistry,, Univ. of Tenn., Oak Ridge Nat. Lab.

Phone: (949)824-8705, 8367, 4713
Fax: (949)824-8413
Email: bjtrombe@uci.edu

University of California, Irvine
Beckman Laser Institute
Mail Code: 1475
Irvine, CA 92612-1475

picture of Bruce J. Tromberg

Research
Interests
Lasers, near infrared spectroscopy, non-invasive diagnostics, photomedicine, biomedical optics, photodynamic therapy
   
URL www.bli.uci.edu/research/bjt/bjt.html
   
Research
Abstract
Optical Spectroscopy and Selective Photochemistry in Cells and Tissues.

My research involves the development of optical techniques to non-invasively monitor and perturb physiological processes in tissues and cells. In order to describe the optical characteristics of thick tissues we have developed a method, known as Photon Migration, that can be used to quantitatively measure light scattering and absorption on a picosecond timescale. We have devised biophysical models and constructed instrumentation for measuring parameters such as hemoglobin oxygenation, tissue water content, relative blood volume, and cell size/shape. We are currently applying this technology to non-invasive functional imaging of tumors and dysplastic lesions in human breast, brain, cervix, and uterus. Complementary strategies based on photodynamic inactivation are used to selectively treat cancers upon diagnosis.
   
Publications Zoumi, A. Yeh, A. Tromberg, B.J. Imaging Cells And Extracellular Matrix In Vivo Using Second-Harmonic Generation And Two-Photon Excited Fluorescence, PNAS, 99, 11014 – 11019, 2002.


Shah, N., Cerussi, A., Eker, C., Espinoza, J., Butler, J., Fishkin, J., Hornung, R., Tromberg, B. Non-Invasive Functional Optical Spectroscopy of Human Breast Tissue. . Proceedings of the National Academy of Science, 98, 4420-4425, 2001.
   
  Fishkin, J. B., Coquoz, O., Anderson, E. R., Brenner, M., Tromberg, B. J. Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject. Applied Optics. 36: 10-20, (1997).
   
  Tromberg, B.J., Coquoz, O., Fishkin, J.B., Pham, T., Anderson, E.R., Butler, J., Cahn, M., Gross, J.D., Venugopalan, V., Pham, D. Non-Invasive Measurements of Breast Tissue Optical Properties Using Frequency-Domain Photon Migration. Phil. Trans. Royal Society London B. 352, 661-668 (1997).
   
Graduate Programs Structural Biology and Molecular Biophysics

   
Research Center Beckman Laser Institute
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2377
   
Last updated 07/09/2009