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Christine M. Gall

Professor, Anatomy & Neurobiology
School of Medicine

Professor, Neurobiology and Behavior
School of Biological Sciences

PH.D., University of California, Irvine

Phone: (949) 824-8652, 4251
Fax: (949) 824-1255
Email: cmgall@uci.edu

University of California, Irvine
Gillespie Neuroscience Research Facility
837 Health Sci. Road
Mail Code: 4292
Irvine, CA 92697


Research
Interests
adult synaptic plasticity, neurotrophic factor localization and function, Integrin adhesion molecules, learning, aging
   
URL www.ucihs.uci.edu/anatomy/gall.html
   
Academic
Distinctions
• Research Career Development Award, NINCDS ('84- '89);
• Alfred P. Sloan Fellowship ('82-'84);
• Silver Beaker Award, Outstanding Basic Science Professor, UCI- CCM (1986);
• Kaiser Permanente Award for Excellence in Teaching, UCI-CCM (1989);
• NSF Faculty Award for Women Scientists and Engineers ('91-'96);
• Lauds and Laurels, UCI Alumni Association Award for Distinguished Research (1995);
• Athalie Clark Research Associates Achievement Award, UCI College of Medicine (1996)
• Chair, UCI College of Medicine Academic Senate (2004)
• Journal Editorial Boards: Hippocampus (1990-pres); Journal of Comparative Neurology (1998-04); Experimental Neurology (1999-04); Neuroscience (2000-pres); J. Neurosci. Res
• Society for Neuroscience: Program Committee (1998-2000); Councilor (2000-04)
• Society for Neuroscience Treasurer 2006-07 (Treasurer group: 2005-08)
   
Research
Abstract
Research in the Gall laboratory is focused on mechanisms of neuronal plasticity in the adult brain and, in particular, on the role of regulated changes in neurotrophic factor gene expression and adhesive interactions in plasticity and neuronal protection. Studies in this laboratory and elsewhere have demonstrated that within the adult brain neuronal and glial gene expression is quite dynamic and is regulated by such diverse influences as levels of neuronal activity, hormonal interactions, and adhesive interactions with matrix proteins. We were the first to demonstrate that the expression of different classes of neurotrophic factor genes is regulated by physiological activity and by neuronal degeneration. These results indicate that different trophic "programs" are activated by different functional demands placed on the nervous system and that these programs coordinate complex cellular responses that are likely to play critical roles in processes as activity- dependent neuronal plasticity (i.e., learning) and reactive synaptogenesis following brain damage. Recent studies have extended our analyses to the consideration of the role of adhesion proteins in regulating neurotrophic factor expression and synaptic plasticity. In particular, we have found that integrins, that serve as receptors for extracellular matrix proteins, are concentrated at synapses, regulate tyrosine kinase signaling cascades within the synapse and, ultimately, regulate the properties of codistributed neurotransmitter receptors and ion channels. Moreover, through effects on calcium influx the integrins regulate neuronal gene expression of neurotrophins. Current studies are resolving integrin-mediated signaling activities and fthe nature of functional interactions between these adhesion proteins and the transmission and trophic functions of the synapse
   
Publications Chen, L.Y., C.S. Rex, Y. Sanaiha, G. Lynch and C.M. Gall. 2010 Learning Induces Neurotrophin Signaling at Hippocampal Synapses. Proc. Natl. Acad Sci. USA 107:7030-7035. PMID: 20356829
   
  Chen, LY*, CS Rex*, A.H. Babayan, E.A. Kramar, G. Lynch, C.M. Galla and J.C. Lauterborn. 2010 Physiological activation of synaptic Rac > PAK signaling is defective in a mouse model of Fragile-X Syndrome. J. Neurosci. 30: 10977-10984.
   
  Rex, C.S., L.Y. Chen, A. Sharma, J. Liu, C.M. Gall, and G. Lynch. 2009 Different Rho GTPase-dependent Signaling Pathways Initiate Sequential Steps in LTP Consolidation. J. Cell Biol. 186: 85-97. PMCID: PMC2712993
   
  Simmons, D.A., C. S. Rex, L. Palmer, V. Pandyarajan, V. Fedulov, C. M. Gall, and G. Lynch 2009 Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in knock-in Huntington’s Disease mice. Proc. Natl. Acad Sci., USA 106:4906-1911. PMCID: PMC266072
   
  Lynch, G., C.S. Rex, L.Y. Chen and C.M. Gall 2008 The Substrates of Memory: Defects, Treatments and Enhancement. Eur. J. Pharmacol., 585: 2-13.
   
  Lin, C.-Y., L. Hilgenberg, M. Smith, G. Lynch and C.M. Gall 2008 Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Mol. Cell. Neurosci. 37: 770-780.
   
  Chen LY, Rex CS, Casale M, Gall CM, Lynch G (2007) Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci, 27:5363-72.
   
  Lauterborn J.L., C.S. Rex, E.A. Kramar, L.Y. Chen, V. Pandyarajan, G. Lynch and C.M. Gall. 2007 Brain derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J. Neurosci. 27:10685-10694.
   
  Rex, C.S., J.C. Lauterborn, C.-Y. Lin, E.A. Kramár, C.M. Gall and G. Lynch 2006 Restoration of LTP in middle-aged hippocampus following induction of brain-derived neurotrophic factor. J. Neurophys. 96:677-685.
   
  Lin, C-Y., G. Lynch and C.M. Gall, 2005 AMPA receptor stimulation increases alpha5ß1 integrin surface expression, adhesive function and signaling. J. Neurochem., 94: 531-546.
   
  Bernard-Trifilo, J.A., E. A. Kramár, R. Torp, C.-Y. Lin, E. A. Pineda, G. Lynch, C. M. Gall 2005 Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem. 93:834-849.
   
  Lauterborn, J.C., G.S. Troung and C.M. Gall 2003 Intermittant ampakine treatment sustains elevated hippocampal brain derived neurotrophic factor levels in vitro. JPET 2003; 307: 297-305.
   
Professional
Society
Society for Neuroscience
   
Graduate Programs Neurobiology and Behavior

Interdepartmental Neuroscience Program

Cellular and Molecular Biosciences

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2314
   
Last updated 08/19/2010