James H. FallonProfessor Emeritus, Anatomy & Neurobiology Professor, Psychiatry & Human Behavior |
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Research Interests |
Adult stem cells, CNS circuitry, neurotrophic factors, prosthetic interfaces, addiction, neuroananatomy, basal ganglia, limbic system, dopamine, Schizophrenia, Parkinson's and Alzheimer's disease, Human Brain Imaging, art, law, culture, and the brain | |
| URLs | Department of Anatomy and Neurobiology faculty page-Fallon | |
| Brain Engineering Laboratory | ||
| NIH Funtional Biomedical Informatics Research Network (FBIRN) Consortium personnel | ||
| NIH Biomedical Informatics Research Network (BIRN @ NIH/NCRR) | ||
| National Alliance for Medical Imaging Centers WiKi (NAMIC-NIH) | ||
| NIH Roadmap Grant at UCI; Transdisciplinary Imaging Genetics Center (TIGC) | ||
| UCI Beall Center for Art and Technology: Reading Frankenstein | ||
| Neural Architecture and Smart Buildings-Laguna Art Museum | ||
| Creative Leaps International | ||
| "VIRGA TEARS" (novella) | ||
| Associated Solo Artists, Inc. | ||
| Fallon publications abstracts #1 | ||
| Fallon publications abstracts #2 | ||
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Academic Distinctions |
Honorary Doctorate, St Michael's College Academic Hall of Fame, St Michael's College (1st in 100 yr history of the college) Sloan Scholar Fulbright Scholar in East Africa NIH Career Development Award Teacher of the Year (several) in College of Medicine |
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| Appointments |
Elected: Chair of the UCI Faculty/Academic Senate 1998-1999, Chair of the UCI College of Medicine Faculty 1992-1994 |
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Research Abstract |
My research program is primarily in four areas, including adult stem cells, chemical neuroanatomy and circuitry, higher brain functions, and brain imaging. Human Brain Imaging - Extensive collaborations with clinical and basic researchers on imaging genetics studies of depression, schizophrenia, tobacco use, language disorders, personality, intelligence, male-female differences in cognition, consciousness and anesthesia, human cortical development, sleep, emotional memory, imaging genetic studies of psychiatric disorders, modeling of neural circuits, and law, culture, and the brain. Stem Cells and Neurotrophic factors - We have been studying the localization, development, and function of neurotrophic factors in the mammalian brain. We have studied EGF, TGFalpha, TGFbeta, and FGF and have focused on the TGFa family of growth factors since 1982. Experimental approaches include in situ nucleic acid hybridization, immunocytochemistry, minipump infusions, neurotoxic lesions, behavioral pharmacology, fluorescence histochemistry, and retrograde tracing. Present focus is on in vivo regeneration from endogenous stem cells in the brain, and their application to neurodegenerative diseases, stroke, and trauma in humans and have just begun a study to create new neural interfaces for advanced prosthetic limbs and neural chips. Chemical Neuroanatomy- We study of the distribution and connections of chemically defined circuits in the brain and have detailed the dopamine and norepinephrine system, as well as the distribution of opioid peptide and growth factor systems, especially in the basal ganglia, limbic system, and cortex in the developing and adult brain. Higher Brain Functions- I am interested in the neural circuitry and genetics of creativity, artistic talent, psychopathology, criminal behavior, and levels of consciousness. Patents:on request |
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| Publications | Guerra-Crespo, M, Gleason, D., Sistos, A., and Fallon, J.H. (2009) Intranasal Administration of PEGylated Transforming Growth Factor-alpha Improves Behavioral Deficits in a Chronic Stroke Model. Journal of Stroke and Cerebrovascular Diseases. In press. | |
| Guerra-Crespo, M, D. Gleason, A. Sistos, T.Toosky, I. Solaroglu, J.H. Zhang, P.J. Bryant and Fallon J.H.(2009) Transforming Growth Factor-alpha Induces Neurogenesis and Behavioral Improvement in a Chronic Stroke Model. Neuroscience (in press) | ||
| Kim, M.A., Tura, E., Potkin. S.G., Fallon, J.H. , Manoach, D.S., Calhoun, V.D., FBIRN, Turner, J.A. (2009) Working memory circuitry in schizophrenia, as revealed by partial least squares analysis. Biological Psychiatry | ||
| Potkin, S.G. 1*, Jessica A. Turner1, James A. Fallon1, Anita Lakatos1, David B. Keator1, Guia Guffanti2, Fabio Macciardi2*, FBIRN1 (2008) Gene Discovery Through Imaging Genetics: Identification of Two Novel Genes Associated with Schizophrenia. . International Congress on Schizophrenia Research | ||
| Potkin, S.G., Guffanti, G. Lakatos, A., Turner, J., Kruggel, F. Fallon, J.H., Saykin, A, Orro, A., Lupoli, S., Salvi, E., Weiner,M., Macciardi, F.,(2009) Hippocampal Atrophy as a Quantitative Trait in a Genome-wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease. PloS ONE. (in press) | ||
| Fallon, J.H. and Keator, D.B. (2008) Commentary on In Silico Modeling System: A National Research Resource for Simulation of Complex Brain Disorders. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Jan;5(1):5-6 | ||
| Amen, D.G., Prunella, J.R., Fallon, J.H., Amen, B., Hanks, C (2008) High Resolution Brain SPECT Imaging In Completed Suicides. J Neuropsychiatry and Clinical Neurosciences. (in press). | ||
| Gehricke, J.G., Potkin, S.G., Leslie, F.M., Loughlin, S.E., Whalen, C. K., Jamner, L.D., Mbogori, J. and Fallon, J.H. (2009) Nicotine-induced brain metabolism associated with anger provocation. Behavioral and Brain Functions (in press). | ||
| Potkin, S.G., Turner, J.A., Fallon, J.H., Laurielleo, J., Guffanti, G., Lakatos, A., Macciardi, F., FBIRN (2009) A Genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophrenia Bulletin. Jan;35(1):96-108. Epub 2008 Nov 20. | ||
| Gleason, D, Fallon JH, Guerra, M, Liu, J-C, Bryant, PJ (2008) Ependymal Stem Cells Divide Asymmetrically and Transfer Progeny into the Subventricular Zone when Activated by Injury. Neuroscience (in press). | ||
| Kikinis, Z, Fallon, J.H., , M. Niznikiewicz3, P. Nestor C. Wible, C. Davidson, L. Bobrow, P. Pelavin1 B. Fischl, A. Yendiki, R.W. McCarley, R. Kikinis, M. Kubicki, M.E. Shenton (2009) Gray matter volume reduction in rostra middle frontal gyrus in patients with chronic schizophrenia. In press. | ||
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Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, Macciardi F. (2009) Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.Mol Psychiatry. 2009 Apr;14(4):416-28. Epub 2008 Dec 9. |
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| Hong, C.,Harris, J.C., Pearlson, G.D., Kim, J-S., Calhoun, V.D., Fallon, J.H.,Golay, X., Gillen, J.S., Zijl, P.C..M., Zee, D.S., Pekar, J.J. (2008) fMRI Evidence for Multisensory Recruitment Associated with Rapid Eye Movements during Sleep. Human Brain Mapping (in press) | ||
| Labus, JS , B.N. Naliboff, J. Fallon, S.M. Berman, B. Suyenobu, J.A. Bueller, M. Mandelkern and E.A. Mayer (2008) Sex differences in brain activity during aversive visceral stimulation and its expectation in patients with chronic abdominal pain: A network analysis. NeuroImage 41:3, 1032-1043. | ||
| Tura, E., Turner, J.A., Fallon, J.A., Potkin, S.G. (2008) Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia. Neuroreport Apr 16;19(6):603-7. | ||
| Wu JC, Gillin JC, Buchsbaum MS, Schachat C, Darnall LA, Keator DB, Fallon JH, Bunney WE. (2008) Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depression. J Affect Disord. 107(1-3):181-6. Epub 2007 Nov 26. | ||
| Su, J., Guerra-Crespo, M. & Fallon, J. H. (2007). The therapeutic potential of transforming growth factor a as a treatment for chronic stroke. Journal of Investigative Medicine 55, S151-S151. | ||
| Petrovic, V, Fallon, H, & Kuester, F (2007) Visualizing Whole-Brain DTI Tractography with GPU-based Tuboids and LoD Management IEEE | ||
| Fallon, J.H., Keator, D.B., Mbogori,, J. , Taylor, D., and Potkin, S.G. (2004) Gender: A major determinant of brain response to nicotine. International Journal of Neuropharmacology. (December, 2004). | ||
| Fallon, JH (2006) Neuroanatomical background to understanding the brain of the young psychopath. Ohio State Journal of Criminal Law. 3:34 341-367. | ||
| Fallon, JH, Keator, D, Mbgori, J., Turner, J., and Potkin, SG (2004) Hostility predicts susceptibility to nicotine dependence. Cognitive Brain Research 18:142-148. | ||
| Fallon JH, Reid JR, Kinyamu RM, Opole IO, Opole R, Baratta J, Korc M, Endo T, Duong A, Nguyen G, Karkehebadhi M, Twardzik D, Loughlin SE (2000) In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc. Natl. Acad. Sci. 26(97): 14686-14691. | ||
| Fallon, JH, Opole, IO, Potkin, SG (2003) The Neuroanatomy of Schizophrenia: Circuitry and Neurotransmitter Systems. Clinical Neuroscience. Research. 3:77-107. | ||
| Wakana, S, Panzenboeck, M., Fallon, JH, Hua, K. Zhang , J., Jiang, H. Dubey, P., Blitz, A., van Zijl, P., Mori, S. (2006) Tractography-based Quantitative Analyses of White Matter Anatomy: Tracking Protocol, Reproducibility and Tract-Specific Quantification of Cerebral Hemisphere. Neuroimage.(in press) | ||
| Shankle, WR, Hara, J, O’Heany,T, Bjornsen, L, Gade, G., Leport, P., Ali, M., Rayhaun, A., Kim, J., Malkazian, D., Raimo, M., Reyes, L. Amen, D., Fallon, JH, Kim, R., Rudy, R. (2006) NeuroSPECT Demonstrates Increased Cortical Function in Alzheimer’s Disease Patients For At Least Two Years After Omental Transposition Neurosurgery. Alasbimn Online Journal. Number 31(Article N° AJ31-1). http://www2.alasbimnjournal.cl/alasbimn/CDA/imprime/0,1208,PRT%253D15971,00.html | ||
| Wu, J.C., Gillis, J.C., Buchsbaum , M.S., Chen, P., Keator , D.B., Wu, N.K. Darnall, L.A., Fallon, J.H., BunneyW.E. (2006) Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep. Neuropsychopharmacology. (in press). | ||
| Melonakos J, Al-Hakim, R., Fallon, J.H., and Tannenbaum, A. (2006) Knowledge-Based Segmentation of Brain MRI Scans Using the Insight Toolkit. Insight Journal (NAMIC/BIRN). | ||
| Tuszynski, M.H., Thal, L., Pay, M., Hoi-Sang, U., Bakay, R., Salmon, D., Blesch, A., Vahlsing, L., Ho, G., Tong, G., Potkin, S., Fallon, J.H., Mufson, E., Kordower, J., Gall, C., Connor, J. (2005) A Phase I Clinical Trial of Nerve Growth Factor Gene Therapy for Alzheimer’s Disease. Nature Medicine April 2005 on-line. | ||
| Bose S, Mok AC, Fallon JH, Potkin SG. (2006) Three-month change in cerebral glucose metabolism in patients with nonarteritic ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2006 Jan 13;1-4. | ||
| Turner, J.A., Smyth, P., Macciardi, F., Fallon, J.H., Kennedy, J.L., Potkin, S.G. (2006) Imaging phenotypes and genotypes in schizophrenia. Neuroscience 4 (1) | ||
| Potkin, SG, Alva, G, Keator, D, Carreon, D., Wu, JC, Fleming, K, and Fallon, JH (2002) A PET Study of the Pathophysiology of Negative Symptoms in Schizophrenia. Am J Psychiatry 159: 227-237. | ||
| Shankle, W. R., Hara, J., Fallon, J. H., Landing, B. H. How the brain develops and how it functions: application of neuroanatomical data of the developing human cerebral cortex to computational models. In Computational Neuroanatomy: Principles and Methods.Ed G Ascoli, Humana Press Inc. Ch. 18 2002. | ||
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Potkin, SG, Basile, V, Marsellis, M, Badri, F, Keator, D, Wu, J, Alva, G, Carreon, D, Bunney, W, Fallon, J, Kennedy J. (2003) D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine. Molecular Psychiatry 8:109-133. |
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Landing, BH, Shankle, WR, Hara, J, Brannock, J, and Fallon, JH (2002) The development of Structure and Function in the Postnatal Human Cerebral Cortex from Birth to 72 Months: Changes in thickness of Layers II and III correlate to the onset of New Age-Specific Behaviors. Ped. Path. Molecular Medicine21:321-342. |
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Shankle WR, Rafii MS, Landing BH, and Fallon JH (1999) Approximate doubling of the numbers of neurons in the postnatal human cortex and in 35 specific cytoarchitectonic areas from birth to 72 months. Pediatric and Developmental Pathology 2:244-259. |
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| McCormick,BH, W Koh, WR Shankle, JH Fallon (2000) Geometric modeling of local cortical networks. Neurocomputing 32-33:461-469. | ||
| McCormick, BH, RW DeVaul, WR Shankle, JH Fallon (2000) Modeling neuron spatial distribution and morphology in the developing human cerebral cortex. Neurocomputing 32-33:897-904. | ||
| Wu J, Iacono R, Ayman M, Salmon E, Lin S, Carlson J, Keator D, Lee A, Najafi A, Fallon, J (2000) Correlation of intellectual impairment in Parkinson's disease with FDG-PET scan. Neuroreport;11(10):2139-44. | ||
| Potkin, SG,.Fallon, JH (2002) Brain Metabolic Effects of Neotrofin in Patients with Alzheimer's Disease. Brain Research 951:87-95 | ||
| Cahill L, Haier R, White N, Fallon, J, Kilpatrick L, Lawrence C, Potkin S, Alkire M (2001) Sex-related difference in amygdala activity during emotionally influenced memory storage. Neurobiology Learning Mem. 75: 1-9. | ||
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Gottschalk LA, Fronczek J, Abel L, and Fallon JH (2001) The cerebral neurobiology of anxiety, anxiety-displacement, and anxiety-denial. Psychotherapy and Psychosomatics. 70(1):17-24. |
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Morrissey JJ, Dauphinee M, and Fallon JH (1999) Cellular telephone signal(Iridium) exposure to the heads of mice increases c-fos expression in stress and thermoregulatory regions consistent with tissue heating. Neuroscience 92:1539- 46. |
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Alkire MT, Haier RJ, and Fallon JH (2000) Toward a unified theory of narcosis: Brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Consciousness & Cognition, 9:370-386. |
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| Cho, Z.H., Wong, E, Fallon, J.H. (2001) Neuro-Acupuncture Vol 1 Neuroscience Basics | ||
| Grants | Growth Factor Treatment of Subacute Stroke (PI) | |
| NIH BIRN Grant; FBIRN (Function Biomedical Informatics Research Network): Schizophrenia and fMRI 2002-2011 (Co-I) | ||
| California Institute for Regenerative Medicine (CIRM) Stem Cell Training Grant: 2006-2011 (Member/Mentor/Co-I) | ||
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Professional Societies |
Society for Neuroscience CPP Cure Parkinson's Program: Co-Founder, Board Member |
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| Other Experience |
Chair and Member, Scientific Advisory Board and Corporate Board (Several NFP and Several FP Firms; Available upon request) |
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| Graduate Programs |
Neurobiology Interdepartmental Neuroscience Program Cellular and Molecular Biosciences |
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| Research Centers | Stem Cell Consortium UCI | |
| NAMIC (National Alliance for Medical Imaging Consortium) NIH | ||
| NIH TIGC Transdisciplinary Imaging Genetics Center | ||
| NIH MBIRN Center and NIH/NCRR Brain Informatics Research Network: FBIRN Scientific Coordinator | ||
| Brain Imaging Center | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2303 | |
| Last updated | 11/18/2009 | |