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Stephen Claude Bondy

Professor, Medicine
School of Medicine

Professor, Pharmacology
School of Medicine

M.A., Cambridge


Ph. D., Birmingham, England

Phone: (949) 824-8077
Fax: (949) 824-2070
Email: scbondy@uci.edu

University of California, Irvine
Center for Occupational and Environmental Health
Department of Medicine, University of California, Irvine
100 Theory, Suite 100
Mail Code: 1830
Irvine, CA 92617

picture of Stephen Claude Bondy

Research
Interests
Brain aging; Environmental and dietary agents that promote or retard such aging
   
URLs Graduate Program in Environmental Toxicology
   
Pharmacology Home Page
   
See below for selected publications or click here for additional publication listings available via PubMed
   
Academic
Distinctions
INVITED PRESENTATIONS

2012: Bondy, S. C. Dietary melatonin reverses age-related elevations in inflammatory genes and also reduces tumor size and number in aged mice. 45th Winter Conference on Brain Research, Snowbird, Utah

2011: Keynote Speaker (Birchall Lecture), 9th International Keele Meeting on Aluminum, Niagara Falls, Canada.

2011: Invited Speaker: Slowing Down Brain Aging with Dietary Melatonin, 2nd Annual World Congress of NeuroTalk, Dalian, China, 2011.

2011: Co-chair of session on Aging, Dementia and Repair, 2nd Annual World Congress of NeuroTalk, Dalian, China

2010: Co-chair of panel on “Neuro-inflammation in Aging and Disease” Winter Conference on Brain Research, Breckenridge, CO.


Committees
2009-2012; UCI Council on Academic Personnel (CAP).
2010-2013: Library Committee, UCI College of Medicine
2010-2011: NIH Proposal UCI Pre-Review Committee.
2010-2111 UCI School of Medicine Admissions Committee.

Review Committees
2011: NIH/NIEHS ZRG-1 IFCN-C Special Emphasis Panel: Learning, Alcohol and Neurotoxicology.
2012: University Grants Committee, Hong Kong.
2012: Alzheimer’s Association.
2011-2012: NIH/NIEHS Special Emphasis Review Panel of Extramural Loan Repayment Program.
2012: Hungarian academy of Medical Sciences

EDITORIAL BOARDS:
Fibers (Editor-in-Chief)
Free Radicals in Biology and Medicine
Neurochemistry International
Neurotoxicology
Toxicology and Industrial Health
International Journal of Environmental Research
Int. Journal of Toxicology, Occupational and Environmental Health
Current Aging Science
Geriatric Medicine
International Journal of Environmental Research
ISRN Toxicology

THESIS COMMITTEES
2011; University of Karachi, Pakistan Examination committee of doctoral candidate,Tanveer Fatma

2012: Agnesia Avanesian (UCI Dept. of Pharmacology) Advancement to candidacy.

2012: University of Karachi, Pakistan. Examination committee of doctoral candidate, Zahra Yaqeen.

2012: Quaid-i-Azam University, Pakistan. Examination committee of doctoral candidate, Mr. Munawar Raza Kazmi
   
Research
Abstract
Research focuses on the role of environmental factors in the initiation or potentiation of neurodegenerative diseases. In this context the emphasis is on the contribution of inflammatory events to neural aging. The potential slowing of brain aging by antioxidants and antiinflammatory agents such as melatonin, is also under investigation. Such retardation could reduce the incidence of specific age-related neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.
   
Publications RECENT PUBLICATIONS:



Bondy, S. C. and Maiese, K. (eds.): Oxidative Stress and its Relation to Aging. Volume in series: Oxidative Stress in Applied Basic Research and Clinical Practice. 2010.



Bondy, S. C. and Sharman, E. H. Melatonin, oxidative stress and the aging brain. In: Oxidative Stress in Basic Research and Clinical Practice : Aging and Age-Related Disorders (eds: Bondy, S. C. and Maiese, K.), Humana Press, Totowa NJ, pp. 339-357, 2010.



Lahiri, D. K., Ghosh, C., Rogers, J. T., Bondy, S. C., and Greig, N. H. Role of nitric oxide in neurodegeneration and vulnerability of neuronal cells to nitric oxide metabolites and reactive oxygen species. In: Oxidative Stress in Basic Research and Clinical Practice : Aging and Age-

Related Disorders. (eds: Bondy, S. C. and Maiese, K.), Humana Press, Totowa NJ, pp. 399-415, 2010.



Bondy, S. C., Li, H., Zhou, J., Wu, M., Bailey, J. A. and Lahiri, D. K. Melatonin alters age-related changes in transcription factors and kinase activation. Neurochem. Res. 35: 2035-2042, 2010. (PMID: 20535557).



Ali, S. F. and Bondy, S. C. Red wine but not ethanol at low doses can protect against the neurotoxicity of methamphetamine. Brain Res. 1346:247-250, 2010. (PMID 20510887).



Bondy, S. C. The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology 31: 575-581, 2010. (PMID: 20553758).



Sharman, E. H., Sharman, K. Z., and Bondy, S.C. Extended exposure to dietary melatonin reduces tumor number and size in aged mice. Exptl. Geront.46:18-22,2011. (PMID: 20837128).



Zhou, J., Li, Z., Hou, D., Tang, J., Sun, J., and Bondy, S. C. Paeonol increases levels of cytochrome oxidase and vascular actin, and improves behavior in a rat model of Alzheimer's disease. Brain Research 1388: 141-147, 2011.



Bondy, S. C. Nanoparticles and colloids as contributing factors in neurodegenerative disease. Int. J. Env. Res. Public Health 8: 2200-2211, 2011.



Bondy, S. C. (ed.) Advances in Environmental Neurotoxicology. Special Issue of Internat. J. Environ. Research and Public Health, 8, 2011.



Bondy, S. C. Nanoparticles and colloids as contributing factors in neurodegenerative disease. Int. J. Env. Res. Public Health 8: 2200-2211, 2011.



Bondy, S. C. Can environmentally relevant levels of aluminium promote the onset and progression of neurodegenerative diseases? Current Inorg. Chem. 2: 40-45, 2012



Bondy, S. C. (Guest Editor), Advances in Environmental Neurotoxicology. Special Issue of Int. J. Env. Res. and Public Health, 8, 2011.



Zhou, J. , Zhou, L., Wang, F., Yang, F., Wen, P., Li, W. Song, Z, Bondy, S. C. Melatonin decreases levels of S100?and NF?B , increases levels of synaptophysin in a rat model of Alzheimer's disease, Current Aging Research (in press, 2012).



Lung, S., Li, H., Bondy, S. C., Campbell, A. Low concentrations of copper in drinking water increases AP-1 binding in the brain. Toxicology (submitted, 2012).
   
Professional
Societies
Society for Neuroscience
Toxicology Society
American Aging Association
International Neurotoxicology Association
   
Graduate Programs Environmental Toxicology

Pharmacological Sciences

   
Research Center Irvine Center for Occupational & Environmental Medicine
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2283
   
Last updated 10/22/2012