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William E. Bunney

Distinguished Professor, Psychiatry & Human Behavior

M.D., University of Pennsylvania

Phone: (949) 824-4242
Fax: (949) 824-1787
Email: webunney@uci.edu

University of California, Irvine
D438 Medical Sciences 1
Mail Code: 1675
Irvine, CA 92697-1675

picture of William E. Bunney

The pathophysiology and treatment of the serious mental disorders Schizophrenia, Bipolar Disorder, and Major Depressive Disorder using brain imaging, and genetic and genomic approaches.
Dr. Bunney’s major research interests involve studies of mood disorders, and schizophrenia. These include investigations of the efficacy and mode of action of rapid-acting antidepressant treatments (efficacy within 24 hours); MRI and PET brain imaging studies; genetic and genomic studies; investigation of brain circuitry abnormalities; and the role in depression of altered clock gene machinery which modulate the 24-hour circadian rhythms consistently reported in mood disorders).
Publications Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ, Akil H, Bunney WE. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. PNAS / doi:10.1073/ PNAS 1305814110, May 2013
  Bunney BG, Bunney WE. Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biol Psychiatry. June 2013
  Medina A, Seasholtz AF, Sharma V, Burke S, Bunney W, Jr., Myers RM, et al. Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder. Journal of psychiatric research. 2013;47(3):307-14.
  Patterson JV, Sandman CA, Jin Y, Kemp AS, Potkin SG, Bunney WE, Jr. Gating of a novel brain potential is associated with perceptual anomalies in bipolar disorder. Bipolar Disorders. 2013;15(3):314-25.
  Sequeira A, Martin MV, Rollins B, Moon EA, Bunney WE, Macciardi F, et al. Mitochondrial mutations and polymorphisms in psychiatric disorders. Frontiers in Genetics. 2012;3:103.
  Bunney BG, Bunney WE. Rapid-Acting antidepressant strategies: mechanisms of action. Intl Journal of Neuropsychopharmacology Vol 15, Issue 5, Pages 695-713, DOI: 10.1017/S1461145711000927. June 2012
  Sequeira a, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, Schatzberg AF, Watson SJ, Akil H, Myers RM, Jones EG, Bunney WE, Vawter MP. Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide. PLOS ONE Volume: 7 Issue: 4 Article Number: e35367 DOI: 10.1371/journal.pone.0035367 April 2012
  Mee S, Bunney BG, Bunney WE, Hetrick W, Potkin SG, Reist C. Assessment of psychological pain in major depressive episodes. Journal of Psychiatric Research. Doi:10.1016/j.psychires .2011.06.011. November 2011.
  Sklar P, Ripke S, Scott LJ, et. al. Large-Scale Genome-wide Association Analysis of Bipolar Disorder Identifies a New Susceptibility Locus Near ODZ4. Group Author(s): Psychiat GWAS Consortium Bipolar D, Nature Genetics Volume: 43 Issue: 10 Pages: 977-U162 DOI: 10.1038/ng.943 October 2011
  Bellet MM, Vawter MP, Bunney BG, Bunney WE, Sassone-Corsi P. Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression. PLoS ONE 11-13223R1 10.1371/journal.pone.0023982. Aug 2011.
  Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, Schatzberg AF, Myers RM, Akil H, Watson SJ. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psych. Volume: 16 Issue: 6 Pages: 634-646 DOI: 10.1038/mp.2010.44 Published: Jun 2011
  Lavebratt C, Sjoholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, Adolfsson R, Forsell Y, Wu JC, Kelsoe JR, Partonen T, Schalling M. CRY2 is Associated with Depression. PLoS ONE, February 2010/Vol 5/Issue 2/e9407.
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2279
Last updated 07/17/2013