William E. Bunney

Distinguished Professor, Psychiatry & Human Behavior

M.D., University of Pennsylvania

Phone: (949) 824-4242
Fax: (949) 824-1787
Email: webunney@uci.edu

University of California, Irvine
D438 Medical Sciences 1
Mail Code: 1675
Irvine, CA 92697-1675

picture of William E. Bunney

The pathophysiology and treatment of the serious mental disorders Schizophrenia, Bipolar Disorder, and Major Depressive Disorder using brain imaging, and genetic and genomic approaches.
Dr. Bunney’s major research interests involve work on serious psychiatric disorders--major depressive disorder (MDD), bipolar disorder (BPD) and schizophrenia. These include studies on diagnosis, rapid treatment strategies, etiology, brain imaging studies, genetic and genomic research, biomarkers, the role of clock gene abnormalities in MDD and the investigation of brain circuitry alterations. Dr. Bunney received his M.D. from the University of Pennsylvania Medical School and completed his residency in Psychiatry at Yale University School of Medicine. Following his residency, he was recruited by Dr. David Hamburg to the Intramural Program of the NIMH where he subsequently held a number of positions including Section Chief, Lab Chief, Acting Director of the Intramural Program of the NIMH, and the Director of the Division of Narcotic Addiction and Drug Abuse. During his tenure, his division expanded the number of drug addiction treatment centers from 23 to 140 throughout the nation, and established eight university-based research programs on substance abuse. Later at the School of Medicine, University of California Irvine, Dr. Bunney served as the Della Martin Chair Psychiatry, Distinguished Professor, and Senior Associate Dean for Research and Graduate Studies. Dr. Bunney received a number of national and international research awards including the APA Hofheimer Research Award, the International Anna-Monika Award and the NARSAD Nora Maddox Falcone Prize for Outstanding Achievement in Affective Disorders Research. He was awarded the 2011 Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine / National Academy of Sciences, the 2012 Pioneer Award from the Collegium Internationale Neuro-psychopharmacologicum (CINP), and the 2012 Yale Distinguished Alumni Award. Dr. Bunney was also elected to the Institute of Medicine of the National Academy of Sciences, and subsequently designated a Lifetime National Associate of the National Academy of Sciences. He was elected President of national and international societies including the Psychiatric Research Society; the American College of Neuropsychopharmacology; and the international organization CINP. He currently serves on the National Scientific Advisory Board of Brain and Behavior Research Foundation (formerly NARSAD), the Harvard International Brain Repository, the WHO Expert Panel on Mental Health, and was previously appointed for a term as Executive Vice President of the National Academies Corporation. Dr. Bunney is the author of more than 430 scientific publications that have been cited over 31,200 times. His H factor (from Google Scholar database) score=98 (98 papers cited over 98 times); 55 papers were cited between 150 and 1170 times. His work has provided extensive evidence and insight into the etiology and pathophysiology of the major psychiatric disorders.
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Publications Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ, Akil H, Bunney WE. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. PNAS / doi:10.1073/ PNAS 1305814110, May 2013
  Bunney BG, Bunney WE. Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biol Psychiatry. June 2013
  Medina A, Seasholtz AF, Sharma V, Burke S, Bunney W, Jr., Myers RM, et al. Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder. Journal of psychiatric research. 2013;47(3):307-14.
  Patterson JV, Sandman CA, Jin Y, Kemp AS, Potkin SG, Bunney WE, Jr. Gating of a novel brain potential is associated with perceptual anomalies in bipolar disorder. Bipolar Disorders. 2013;15(3):314-25.
  Sequeira A, Martin MV, Rollins B, Moon EA, Bunney WE, Macciardi F, et al. Mitochondrial mutations and polymorphisms in psychiatric disorders. Frontiers in Genetics. 2012;3:103.
  Bunney BG, Bunney WE. Rapid-Acting antidepressant strategies: mechanisms of action. Intl Journal of Neuropsychopharmacology Vol 15, Issue 5, Pages 695-713, DOI: 10.1017/S1461145711000927. June 2012
  Sequeira a, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, Schatzberg AF, Watson SJ, Akil H, Myers RM, Jones EG, Bunney WE, Vawter MP. Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide. PLOS ONE Volume: 7 Issue: 4 Article Number: e35367 DOI: 10.1371/journal.pone.0035367 April 2012
  Mee S, Bunney BG, Bunney WE, Hetrick W, Potkin SG, Reist C. Assessment of psychological pain in major depressive episodes. Journal of Psychiatric Research. Doi:10.1016/j.psychires .2011.06.011. November 2011.
  Sklar P, Ripke S, Scott LJ, et. al. Large-Scale Genome-wide Association Analysis of Bipolar Disorder Identifies a New Susceptibility Locus Near ODZ4. Group Author(s): Psychiat GWAS Consortium Bipolar D, Nature Genetics Volume: 43 Issue: 10 Pages: 977-U162 DOI: 10.1038/ng.943 October 2011
  Bellet MM, Vawter MP, Bunney BG, Bunney WE, Sassone-Corsi P. Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression. PLoS ONE 11-13223R1 10.1371/journal.pone.0023982. Aug 2011.
  Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, Schatzberg AF, Myers RM, Akil H, Watson SJ. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psych. Volume: 16 Issue: 6 Pages: 634-646 DOI: 10.1038/mp.2010.44 Published: Jun 2011
  Lavebratt C, Sjoholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, Adolfsson R, Forsell Y, Wu JC, Kelsoe JR, Partonen T, Schalling M. CRY2 is Associated with Depression. PLoS ONE, February 2010/Vol 5/Issue 2/e9407.
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Last updated 07/17/2014