William E. BunneyDistinguished Professor, Psychiatry & Human Behavior |
|
|
Research Abstract |
Major research interests involve clinical psychobiological studies of manic-depressive illness, and schizophrenia. These include behavioral studies, studies of the efficacy and mode of action of pharmacological agents, brain imaging, genetic studies utilizing and investigations of brain circuitry abnormalities which may be related to the major psychoses. Molecular aspects of antidepressant pharmacology, how antidepressant compounds interact with their receptors (specifically serotonin receptors), and the molecular basis of mood. | |
| Publications |
Akbarian S; Kim JJ; Potkin SG; Hagman JO; Tafazzoli A; Bunney WE Jr; Jones EG. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Archives of General Psychiatry, 1995 Apr, 52(4):258-66; discussion 267-78. Reist C; Chen CC; Chhoeu A; Berry RB; Bunney WE Jr. Effects of sleep on the antidepressant response to sleep deprivation. Biological Psychiatry, 1994 May 15, 35(10):794-7. |
|
|
Siegel BV Jr; Buchsbaum MS; Bunney WE Jr; Gottschalk LA; Haier RJ; Lohr JB; Lottenberg S; Najafi A; Nuechterlein KH; Potkin SG; et al. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. American Journal of Psychiatry, 1993 Sep, 150(9):1325-36. Akbarian S; Bunney WE Jr; Potkin SG; Wigal SB; Hagman JO; Sandman CA; Jones EG. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Archives of General Psychiatry, 1993 Mar, 50(3):169-77. |
||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2279 | |
| Last updated | 04/22/2002 | |