William E. Bunney

Distinguished Professor, Psychiatry & Human Behavior


M.D., University of Pennsylvania

Phone: (949) 824-4242
Fax: (949) 824-1787
Email: webunney@uci.edu

University of California, Irvine
D438 Medical Sciences 1
Mail Code: 1675
Irvine, CA 92697-1675

picture of William E. Bunney

Research
Interests
The pathophysiology and treatment of the serious mental disorders Schizophrenia, Bipolar Disorder, and Major Depressive Disorder using brain imaging, and genetic and genomic approaches.
   
Research
Abstract
Dr. Bunney’s major research interests involve work on serious psychiatric disorders--major depressive disorder (MDD), bipolar disorder (BPD) and schizophrenia. These include studies on diagnosis, rapid treatment strategies, etiology, brain imaging studies, genetic and genomic research, suicide biomarkers, the role of clock gene abnormalities in MDD, and the investigation of brain circuitry alterations. Dr. Bunney received his M.D. from the University of Pennsylvania Medical School and completed his residency in Psychiatry at Yale University School of Medicine. Following his residency, he was recruited by Dr. David Hamburg to the Intramural Program of the NIMH where he subsequently held a number of positions including Section Chief, Lab Chief, Acting Director of the Intramural Program of the NIMH, and the Director of the Division of Narcotic Addiction and Drug Abuse. During his tenure, his division expanded the number of drug addiction treatment centers from 23 to 140 throughout the nation, and established eight university-based research programs on substance abuse. The permanent staff was 793, the budget of the Division during this three-year period of time increased from $60 million to a quarter of a billion dollars. Later at the University of California Irvine, Dr. Bunney served as the Della Martin Chair Psychiatry, Distinguished Professor, and now serves as Associate Dean for Research for the School of Medicine.

Dr. Bunney received a number of national and international research awards including the APA Hofheimer Research Award, the International Anna-Monika Award and the NARSAD Nora Maddox Falcone Prize for Outstanding Achievement in Affective Disorders Research. He was awarded the 2011 Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine / National Academy of Sciences; the 2012 Pioneer Award from the Collegium Internationale Neuro-psychopharmacologicum (CINP); the 2012 Yale Distinguished Alumni Award; the 2015 Payne Whitney Clinic Award for Extraordinary Public Service, The Department of Psychiatry, Weill Medical College of Cornell University, New York-Presbyterian Hospital; and the 2016 Distinguished Graduate Award from the Perelman School of Medicine, University of Pennsylvania. Dr. Bunney was also elected to the National Academy of Medicine of the National Academy of Sciences, and subsequently designated by the President of the National Academies the honorific title, “Lifetime National Associate of the National Academy of Sciences”. He was elected President of national and international societies including the Psychiatric Research Society; the American College of Neuropsychopharmacology; and the international organization CINP.

Dr. Bunney currently serves on the National Scientific Advisory Board of Brain and Behavior Research Foundation (formerly NARSAD), the WHO Expert Panel on Mental Health, and was previously appointed for a term as Executive Vice President of the National Academies Corporation. He is the author of 453 scientific publications that have been cited 40,658 times. His H factor (from Google Scholar database) score is111 (111 papers cited over 111 times) 55 papers were cited between 200 and 1351 times.

Dr. Bunney’s work has provided extensive evidence and insight into the etiology and pathophysiology of the major psychiatric disorders.
   
Available Technologies
Publications Reist C, Mee S, Fujimoto K, Ranjani V, Bunney WE, Bunney BG. Assessment of Psychological Pain in Suicidal Veterans. PLOS One. May 2017, In Press. PONE-D-16-42578R2
   
  Orozco-Solis R, Montelier E, Aguilar-Arnal L, Sato S, Vawter MP, Bunney BG, Bunney WE, Sassone-Corsi P. A circadian genomic signature common to ketamine and sleep deprivation in the anterior cingulate cortex. Biol Psychiatry. 2017 Mar 1. pii: S0006-3223(17)31349-5. doi: 10.1016/j.biopsych.2017.02.1176. PMID: 28395871.
   
  Bowling K, Hagenauer M, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG (dc), Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, Akil H, Bunney WE, Li JZ, Cooper SJ, Myers RM. Post-mortem molecular profiling of three psychiatric disorders reveals widespread dysregulation of cell-type associated transcripts and refined disease-related transcription changes. Genome Medicine 2017 In Press.
   
  Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ, Akil H, Bunney WE. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. PNAS / doi:10.1073/ PNAS 1305814110, May 2013
   
  Bunney BG, Bunney WE. Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biol Psychiatry. June 2013
   
  Sequeira A, Martin MV, Rollins B, Moon EA, Bunney WE, Macciardi F, et al. Mitochondrial mutations and polymorphisms in psychiatric disorders. Frontiers in Genetics. 2012;3:103.
   
  Sequeira a, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, Schatzberg AF, Watson SJ, Akil H, Myers RM, Jones EG, Bunney WE, Vawter MP. Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide. PLOS ONE Volume: 7 Issue: 4 Article Number: e35367 DOI: 10.1371/journal.pone.0035367 April 2012
   
  Mee S, Bunney BG, Bunney WE, Hetrick W, Potkin SG, Reist C. Assessment of psychological pain in major depressive episodes. Journal of Psychiatric Research. Doi:10.1016/j.psychires .2011.06.011. November 2011.
   
  Bellet MM, Vawter MP, Bunney BG, Bunney WE, Sassone-Corsi P. Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression. PLoS ONE 11-13223R1 10.1371/journal.pone.0023982. Aug 2011.
   
  Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, Schatzberg AF, Myers RM, Akil H, Watson SJ. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psych. Volume: 16 Issue: 6 Pages: 634-646 DOI: 10.1038/mp.2010.44 Published: Jun 2011
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2279
   
Last updated 07/14/2017