William E. BunneyDistinguished Professor, Psychiatry & Human Behavior Della Martin Chair, Psychiatry |
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Research Interests |
Neuropsychopharmacology, genetics, brain imaging | |
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Research Abstract |
Major research interests involve clinical psychobiological studies of manic-depressive illness, and schizophrenia. These include behavioral studies, studies of the efficacy and mode of action of pharmacological agents, brain imaging, genetic studies utilizing and investigations of brain circuitry abnormalities which may be related to the major psychoses. Molecular aspects of antidepressant pharmacology, how antidepressant compounds interact with their receptors (specifically serotonin receptors), and the molecular basis of mood. | |
| Publications | Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, Schatzberg AF, Myers RM, Akil H and Watson SJ. “Altered Expression of Glutamate Signaling, Growth Factor, and Glia Genes in the Locus Coeruleus of Patients with Major Depression”. Molecular Psychiatry, 1-13. 1359-4184/10 April 2010; doi: 10. 1038/mp.2010.44. | |
| Lavebratt C, Sjoholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, Adolfsson R, Forsell Y, Wu JC, Kelsoe JR, Partonen T, Schalling M. “CRY2 is Associated with Depression”. PLoS ONE, February 2010/Vol 5/Issue 2/e9407. | ||
| Martin MV, Rollins B, Sequeira PA, Mesén A, Byerley W, Stein R, Moon EA, Akil H, Jones EG, Watson SJ, Barchas J, DeLisi LE, Myers RM, Schatzberg A, Bunney WE, Vawter MP. “Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.” BMC Med Genomics. 2009 Sep 22;2:62. | ||
| Patterson JV, Sandman CA, Ring A, Jin Y, Bunney WE. An initial report of a new biological marker for bipolar disorder: P85 evoked brain potential. Bipolar Disorders 2009: 11: 596-609. | ||
| Scott L, Muglia P, Kong X, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li J, Burmeister B, Absher D, Thompson RC, Franks C, Meng F, Antoniades A, Southwick A, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, and Boehnke M. “Genome-wide Association and Meta-Analysis of Bipolar Disorder in Individuals of European Ancestry.” PNAS, May 2009, Vol.106, no.18. 7501-7506. | ||
| Wu JC, Kelsoe JR, Schachat C, Bunney BG, DeModena A, Golshan S, Gillin JC, Potkin SG and Bunney WE. “Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder.” Biological Psychiatry, May 2009, 0006-3223/09/. doi:10.1016j.biopsych.2009.02.018. | ||
| Rollins B, Martin MV, Sequeira PA, Moon EA, Morgan LZ, Watson SJ, Schatzberg AF, Akil H, Myers RM, Jones EG, Wallace DC, Bunney WE, Vawter MP. “Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.” PLoS One, March 2009, Volume 4, Issue 3, e4913. | ||
| Sequeira A, Meng F, Rollins B, Myers RM, Jones EG, Watson SJ, Akil H, Schatzberg AF, Barchas J, Bunney WE, and Vawter MP. “Coding SNPs Included in Exon Arrays for the Study of Psychiatric Disorders.” Molecular Psychiatry (2008) 13, 363-365. doi:10.1038/sj.mp.4002123. | ||
| Atz M, Walsh D, Cartagena P, Li J, Evans S, Choudary P, Overman K, Stein R,Tomita H, Potkin S, Myers R, Watson SJ, Jones EG, Akil H, Bunney WE Jr, Vawter MP; Members of National Institute of Mental Health Conte Center and Pritzker Neuropsychiatric Disorders Research Consortium. Methodological considerations for gene expression profiling of human brain. J Neurosci Methods. 2007 Jul 30;163(2):295-309. Epub (2007) Apr 8. | ||
| Mee S, Bunney BG, Reist C, Potkin SG, and Bunney WE. “Psychological Pain: A Review of Evidence.” Journal of Psychiatric Research, 2006 - oi: 10. 1016 /j. jpsychires. (2006). | ||
| Jin Y, Potkin SG, Kemp AS, Huerta ST, Alva G, Thai TM, Carreon D, Bunney WE Jr. Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia. Schizophr Bull. 2006 Jul;32(3):556-61. Epub 2005 Oct 27. (2006). | ||
| Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WE, Conley RC, Jones EG, Tamminga CA, Guo Y. “Chromatin Alterations Associated with Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia”. Archives of General Psychiatry. 2005 Aug;62(8): 829-40. | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2279 | |
| Last updated | 08/10/2010 | |