Richard T. Robertson

Picture of Richard T. Robertson
Professor Emeritus, Anatomy & Neurobiology
School of Medicine
Professor Emeritus
School of Biological Sciences
Member, Chao Family Comprehensive Cancer Center
Ph.D., University of California, Irvine, 1971, Biological Sciences - Neurobiology
Phone: (949) 824-6553, 2234
Fax: (949) 824-1105
Email: rtrobert@uci.edu
University of California, Irvine
113 Irvine Hall
140A Irvine Hall
Mail Code: 1280
Irvine, CA 92697
Research Interests
1. Liposomal delivery of chemotherapeutic agents; 2. Development of cholinergic systems in forebrain 3. Role of acetylcholinesterase in neural development 4. Tissue culture models of neural development
Academic Distinctions
Fellow, American Association for the Advancement of Science (AAAS)
Appointments
Anatomisk Institut, University of Oslo, Norway
Research Abstract
Dr. Robertson's laboratory has two research interests:

Cancer: use of peptide-containg or immuno-liposomes for delivery of chemotherapeutic drugs to targeted cancer tumor cells.

Neuroscience: mechanisms of axonal target selection in developing cerebral cortex, using tissue slice and dissociated cell culture techniques to understand how cholinergic axons identify and form synapses with cortical neurons.
Publications
Sahyouni, R., P. Gutierrez, E. Gold, R.T. Robertson, and B. Cummings. The effects of concussion on the blood brain barrier in humans and rodents. Journal of Concussion, 2017, 1, 1-17.
Robertson, R.T., Gutierrez P. M., Baratta, J.L., Thordarson, K., Braslow, J., Haynes, S.M. and Longmuir, K.J. Development, differentiation, and vascular components of subcutaneous and intrahepatic Hepa129 tumors in a mouse model of hepatocellular carcinoma. Histology and Histopathology, 2016, 31: 403-413.
Robertson, R.T., Levine, S.T., Haynes, S.M., Gutierrez, P., Baratta, J.L., Tan, Z. and Longmuir, K. J. Use of labeled tomato lectin for imaging vascular structures. Histochemistry and Cell Biology, 2015, 143: 225-234.
Lee, Y.-S., A. Danandeh, J. Baratta, J. C.-Y. Lin, J.Yu, and R.T. Robertson. Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test. Experimental Neurology, 2013, 249, 178-186.
Longmuir, K.J., S.M. Haynes, J. Baratta, N. Kasabwalla, and R.T. Robertson, Delivery of lioposomal doxorubicin to liver and hepatocytes in vivo by targeting hepatic heparan sulfate glycosaminoglycan, International Journal of Pharmaceutics, 2009, 382, 222-233.
Robertson, R.T., J. Baratta, S.M. Haynes and K.J. Longmuir. Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate biding sites in liver. Journal of Pharmaceutical Sciences, 2008, 97, 3257-3273.
Baratta, J.L., A. Ngo, B. Lopez, N. Kasabwalla, K.J. Longmuir and R.T. Robertson. Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis. Histochemistry and Cell Biology, 2009, 131, 713-726.
Longmuir, K.J., R.T. Robertson, S. M. Haynes, J.L. Baratta and A. J.Waring. Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharmaceutical Research, 2006, 23, 759-769.
Robertson, R.T., J. Baratta, J. Yu and F.M. LaFerla. Amyloid-? expression in retrosplenial cortex of triple trangenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience, 2009, 164, 1334-1346.
Robertson, R.T., J. Baratta, J. Yu and K.M. Guthrie. A role for neurotrophin 3 in target selection by developing cholinergic axonal projections to cerebral cortex. Neuroscience, 2006, 143, 523-539.
Robertson, R.T., K.A. Gallardo, K.J. Claytor, D.H. Ha, K.-K. Ku, B.P. Yu, J.C. Lauterborn, R.G. Wiley, J. Yu,
C.M. Gall and F.M. Leslie. Neonatal treatment with 192 IgG-saporin produces long term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons. Cerebral Cortex, 1998; 8: 142-155.
Tsai, E.S., S.J. Haraldson, J. Baratta, A.D. Lander, J. Yu and R.T. Robertson, Basal forebrain cholinergic cell distribution and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience, 2002, 115, 815-827.
Ha DH, Robertson RT, Roshanaei M, Weiss JH. Enhanced survival and morphological features of basal forebrain cholinergic neurons in vitro: role neurotrophins other potential cortically derived trophic factors. Journal of Comparative Neurology, 1999 Apr 5;406(2):156-70.
Professional Societies
Society for Neuroscience
American Association of Anatomists
Other Experience
NATO Postdoctoral Fellow
University of Oslo, Norway 1971—1972
Visiting Scientist
Sandoz Pharmaceuticals 1986—1986
Graduate Programs
Interdepartmental Neuroscience Program
Research Centers
Cancer Center
Last updated
10/11/2017