Hubert C. Pirkle

Picture of Hubert C. Pirkle
Professor Emeritus, Pathology
School of Medicine
M.D., Indiana University, 1949
Phone: (949) 824-6575
Fax: (949) 824-2160
Email: hcpirkle@uci.edu
University of California, Irvine
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-4800
Academic Distinctions
Markle Scholar in Medical Science
Appointments
Visiting Investigator, Karolinska Institute
Research Abstract
Research interests focus on the structure-function studies on thrombin-like enzymes and fibrinogen, employing methods of protein chemistry and DNA sequencing. Physicochemical and electron microscopic studies on fibrin formation are also being conducted.
Publications
Henschen-Edman, A.H., I. Theodor, B.F.P. Edwards,
and H. Pirkle: Crotalase, a fibrinogen-clotting snake
venom enzyme: Primary structure and evidence for a
fibrogen recognition exosite different from thrombin.
Thrombos. Haemostas. 81:81-86, 1999.
Pirkle, H. Thrombin-like enzymes from snake venoms:
An updated inventory. Thrombos. Haemostas. 79:
675-683, 1998.
Markland, Jr., F.S. and H. Pirkle. Venombin A, in
"Handbook of Proteolytic Enzymes," A.J. Barrett, F.
Woessner, and N. Rawlings (eds.) Academic Press,
London, 1998, pp. 216-223.
Pirkle, H. and F.S. Markland, Jr. Venombin AB, in
"Handbook of Proteolytic Enzymes," A.J. Barrett, F.
Woessner, and N. Rawlings (eds.) Academic Press,
London, 1998, pp. 223-225.
Pirkle, H. and I. Theodor. Thrombin-like enzymes, in
"Snake Venom Enzymes," G.S. Bailey (ed.), Alaken, Inc.,
Fort Collins, CO 1998, pp. 39-69.
Last updated
10/16/2004