Yutaka Kikkawa
Professor, Pathology
School of Medicine
School of Medicine
Professor, Community & Environmental Medicine
School of Medicine
School of Medicine
M.D., University of Tokyo, 1957
B.S., University of Tokyo, 1953
B.S., University of Tokyo, 1953
University of California, Irvine
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-4800
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-4800
Research Interests
P450, CYP1A1, Oxygen toxicity, Tryptophan
Academic Distinctions
Appointments
Research Abstract
Pulmonary free radical biology primarily relating to various types of the cytochrome P-450 enzyme system are the major fields of interest in this laboratory. These studies are related to the understanding of toxicity of environmental pollutants, oxygen toxicity and ARDS.
Studies are extended for evaluation of sexual differentiation in adulthood after neonatal insults with xenobiotics and hyperoxia.
Studies are extended for evaluation of sexual differentiation in adulthood after neonatal insults with xenobiotics and hyperoxia.
Publications
Khatsenko, O.G., Kikkawa, Y.: Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver. J Pharmacol Exp Therapeut. 280:1563-1470, 1997.
Kikkawa, Y., Fujita, I., Sindhu, R.K.: Neonatal hyperoxia and cytochrome P450 imprinting in adulthood. Ped Res. 35:255-258, 1994.
Kikkawa, Y.: Two decades with the pulmonary surfactant system. Appl Cardiopul Pathphysiol. 5 Suppl 1:65-105, 1995.
Sindhu, R.K., Reisz-Porszasz, S., Kikkawa, Y.: Induction of cytochrome P450 1A1 by photooxidized tryptophan in Hepa lclc7 cells. Biochem Pharmacol. 52:1883-1893, 1996.
Sindhu, R.K., Mitsuhashi, M., Kikkawa, Y.: Inhibition of cytochrome P450 1A1 by antisense phosphorothioate oligonucleotide in Hepa lclc7 cells. Biochem Biophy Res Commun. 229:673-680, 1996.
Link to this profile
https://faculty.uci.edu/profile/?facultyId=2237
https://faculty.uci.edu/profile/?facultyId=2237
Last updated
12/17/2002
12/17/2002