Michael T. KleinmanAdjunct Professor, Community & Environmental Medicine |
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Research Interests |
Inhalation toxicology, oxidative stress and cardiopulmonary diseases. | |
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Academic Distinctions | NY State Regents Scholarship; UCI Committee of 1000 Award | |
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Research Abstract |
Environmental pollutants represent important potential causes of preventable neurological, cardiological and pulmonary diseases. The research in my laboratory uses immunological and molecular methods to examine the mechanisms by which toxic agents affect the lung and heart. Current studies include the effects of ambient particles on blood pressure and heart rate in sensitive animal models. Other studies examine the link between asthma and environmental exposures to ambient particles near real-world pollutant sources, such such as freeways in Los Angeles. | |
| Publications | Kleinman, M.T., Hyde, D., Bufalino, C., Basbaum, C., Bhalla, D.K. and Mautz, W.J Toxicity of Chemical Components of Fine Particles Inhaled by Aged Rats: Effects of Concentration. J. Air and Waste Management Assoc.53: 1080-1087, 2003. | |
| Opperhuizen, A., Buringh, E. And Kleinman, M.T. Compliance with PM standards in the European Union: A Netherlands case study. Environ. Management 53: 24-32, 2003 | ||
| Jenkins, B.M., Mehlschau, J.J., Williams, R.B., Solomon, C., Balmes, J., Kleinman, M. And Smith, J. Rice Straw Smoke Generation System for Controlled Human Inhalation Exposures. Aerosol Sci. And Technol. 37: 437-454, 2003. | ||
| Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 151-158, 2003. | ||
| Chen Y, Douglass T, Jeffes EW, Xu Q, Williams CC, Arpajirakul N, Delgado C, Kleinman M, Sanchez R, Dan Q, Kim RC, Wepsic HT, Jadus MR. Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9 gliomas. Blood 100:1373-1380, 2002. | ||
| Bondy, S.C., Ali, S.F. and Kleinman, M.T. Exposure of mice to tobacco smoke attenuates the toxic effects of methamphetamine on dopamine systems. Toxicol. Letters 118:43-46, 2000. | ||
| Solomon, C., Christian, D. L., Chen, L. L., Welch, B. S., Kleinman, M. T., Dunham, E., Erle, D. J. and Balmes, J. R. Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. European Respiratory Journal 15:922-928, 2000. | ||
| Kleinman, M.T. Health Effects of Carbon Monoxide, in Environmental Toxicants, 2nd Edition M. Lippmann, ed. Van Nostrand Reinhold, publishers, New York, Jan. 2000. | ||
| Kleinman, M.T., Bufalino, C, Rasmussen, R. Hyde, D., Bhalla, D.K. and Mautz, W.J. Toxicity of chemical components of ambient fine particulate matter (PM2.5) inhaled by aged rats. J. Appl. Toxicol. 357-364, 2000. | ||
| Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. 2002, Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 3:197-208. | ||
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Hall JV; Winer AM; Kleinman MT; Lurmann FW; Brajer V; Colome SD. Valuing the health benefits of clean air. Science, 1992 Feb 14, 255(5046):812-7. |
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Professional Societies |
New York Academy of Sciences American Chemical Society Environmental Division American Association for Aerosol Research Air and Waste Management Association |
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| Other Experience |
Industrial hygiene and exposure assessment Environmental Radiochemistry |
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| Graduate Programs |
Environmental Toxicology |
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| Research Center | UCI Comprehensive Cancer Center | |
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2235 | |
| Last updated | 10/14/2004 | |