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Ken W. Cho

Professor, Developmental & Cell Biology
School of Biological Sciences

PH.D., University of Pennsylvania, 1985

Phone: (949) 824-4067, 7950
Fax: (949) 824-4709, 4067
Email: kwcho@uci.edu

University of California, Irvine
4213 McGaugh Hall
Mail Code: 2275
Irvine, CA 92697-230

picture of Ken W. Cho

Growth factor signaling and functional genomics in Xenopus and zebrafish
Pew Scholar, American Cancer Society Award
Recent work has revealed that many of the genes involved in growth control, once misregulated, can cause tumor development. We are particularly interested in two sets of genes, the TGF-b related and Wnt growth factors. These genes are required for proper development of embryonic body structures and the central nervous system. However, misregulation of these genes not only results in various forms of congenital malformations, but also promotes tumor development (e.g., mammary and colon tumors). While these growth factors play central roles during embryogenesis and tumorigenesis, we do not fully understand how they work. In particular, we have not yet identified all of the players (genes) involved in mediating the malformation. A major focus of my laboratory is to try to uncover these genes involved in the regulation of growth control and embryonic development. We believe that in the course of learning how these growth factors control normal development, and how
their misregulation leads to particular malformations, we provide clues for the development of treatments for both congenital malformation and tumor development.
Publications Onai, T. Blitz, I.L., Cho, K.W., and Holland, L.Z. (2010). Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus.Dev Biol. 344:377-89.
  Kim, H.J., Chun, B.G., Shin, H.S., Sun, A., Cho K.W.Y. and Jeon N.L. (2009). Microfluidic culture platform for investigating the proliferation and differentiation of stem cells. Methods in Bioengineering Series: Stem Cell Bioengineering (edited by Parekkadan, B and Yarmush M.L.) (Book chapter). 75-88
  Karaulanov, E., Böttcher, R.T., Stannek, P., Wu, W., Rau, M., Ogata, S., Cho, K.W. and Niehrs, C. (2009). Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. PLoS one.4:5742e.
  Blitz, I.L., and Cho, K.W. (2009). Finding partners: How BMPs select their targets. Dev Dynamics 238:1321-1331.
  Jarikji, Z., Horb, LZ., Shariff1, F., Mandato, C.A., Cho, KW, and Horb, M.E. (2009). The tetraspanin tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. Development 136:1791-1800
  Hayata T, Blitz IL, Iwata N, Cho KW. (2009). Identification of embryonic pancreatic genes using Xenopus DNA microarrays. Dev Dyn. 238:1455-1466
  Maretto S, Müller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ. (2008). Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 318:184-93.
  Peiffer, D., Cho, K.W.Y., and Shin, Y. (2003). Xenopus DNA microarrays. Current Genomics.
  Blitz, I.L., Cho,K.W.Y., Chang,C. (2003). Twisted Gastrulation Loss-of-Function Analyses Reveal its Role as a BMP Inhibitor Involved in Dorsal Specification During Early Xenopus Embryogenesis, Development, 130:4975-4988
  Ring, C., Ogata, S., Meek, L., Song, J., Ohta, T., Miyazono, K., and Cho, K.W.Y. (2002) The role of a Williams-beuren syndrom-associcated helix-tloop-helix domain-containing transcription factor in activin/nodal signaling. Genes & Dev. 16:820-835
  Hashimoto, M., Yuge, M., Cho, K.W.Y. (2002). Nodal signaling in Xenopus gastrulae is cell autonomous and patterned by b-catenin. Dev Biol. 253:125-138.
  Von Bubnoff, A., and Cho, K.W.Y. (2001). Intracellular BMP-Signaling Regulation in Vertebrates: Pathway or Network? Dev. Biol. 239:1-14
  Scott, I.C., Blitz, I.L., Pappano, W.N., Cho,K.W.Y., Greenspan, D.S. (2001) Vertebrate twisted gastrulation is a cofactor involved in BMP antagonism, Nature, 411:720-723.
  Nishita, M., Hashimoto, M, Laurent, M.N., Ueno, N., Shibuya, H, and Cho, K.W.Y. (2000). Interaction between Wnt and TGF-b Signaling Pathways during SpemannÕ s Organizer Formation. Nature 403: 781-785.
Grant PPG (HD38761-01) RO1 (GM59864) RO1 (HD29507 )
Society for Developmental Biology
American Association for the Advancement of Science
Graduate Programs Developmental Biology and Genetics

Research Center Developmental Biology Center
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=2201
Last updated 06/26/2012