Larry E. Overman

Professor, Chemistry
School of Physical Sciences

Distinguished Professor of Chemistry

Ph.D., University of Wisconsin, 1969

B.A., Earlham College, 1965

Phone: (949) 824-7156
Fax: (949) 824-2210

University of California, Irvine
4042A Frederick Reines Hall
Mail Code: 2025
Irvine, CA 92697

picture of Larry E. Overman

Organic, Inorganic, Organometallic and Chemical Biology
URL Overman Group Website
Roger Adams Award in Organic Chemistry, American Chemical Society, 2015; UCI Medal, University of California, Irvine, 2011; American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010; Tetrahedron Prize for Creativity in Organic Chemistry, 2008; The Nagoya Medal of Organic Chemistry, 2007; International Society of Heterocyclic Chemistry Senior Award, 2005; American Chemical Society Arthur C. Cope Award, 2003; UC Irvine Distinguished Faculty Lectureship Award for Research, 2002–2003; Yamada Prize, 2002; Japan Society for the Promotion of Science Fellowship, 2000; S. T. Li Prize for Achievements in Science and Technology, 1999; Centenary Medal, Chemical Society, U.K., 1997; American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995; Guggenheim Fellowship, 1993–1994; Javits Neuroscience Investigator Award, 1985–1992; 1992–1999, American Chemical Society Arthur C. Cope Scholar Award, 1989; Visiting Miller Research Fellow, U.C. Berkeley, 1989; Alexander von Humboldt U.S. Senior Scientist Award, 1985–1987; Camille and Henry Dreyfus Teacher-Scholar Award, 1976–1981; U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981; U.C. Irvine Alumni Association Distinguished Research Award, 1979; Alfred P. Sloan Foundation Fellow, 1975–1977
Appointments NIH Postdoctoral Fellow, Columbia University, 1969–1971
Joined UCI Faculty in 1971
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. We are involved also in collaborative programs in the areas of Golgi and cancer biology.
Available Technologies
Publications “Is There No End to the Total Syntheses of Strychnine? Lessons to be Learned for Strategy and Tactics in Total Synthesis”
Jeffrey S. Cannon and Larry E. Overman
Angewandte Chemie, International Edition 2012, 51, in press
  “Enantioselective Total Synthesis of Aplyviolene”
Larry E. Overman and Martin J. Schnermann
Journal of the American Chemical Society 2011, 133, 16425–16427 PMCID: PMC3205941
  “Divergent Synthesis and Chemical Reactivity of Bicyclic Lactone Fragments of Complex Rearranged Spongian Diterpenes”
Martin J. Schnermann, Christopher M. Beaudry, Nathan E. Genung, Stephen M. Canham, Nicholas L. Untiedt, Breanne D. W. Karanikolas, Christine Sütterlin and Larry E. Overman
Journal of the American Chemical Society 2011, 133, 17494–17503 PMCID: PMC3202687
  “Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ” Stephen M. Canham, Larry E. Overman and Paul S. Tanis
Tetrahedron 2011, 67, 9837–9843 NIHMSID331433
  “Enantioselective Total Synthesis of (+)-Gliocladin C and (+)-Gliocladine C. A Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors”
J. E. DeLorbe, S. Y. Jabri, S. M. Mennen, L. E. Overman and F-L Zhang
Journal of the American Chemical Society 2011, 133, 6549–6552 PMCID: PMC3090078
  “Total Synthesis of (+)-Condylocarpine (+)-Isocondylocarpine, and (+)-Tubotaiwine”
C. L. Martin, S. Nakamura, R. Otte and L. E. Overman
Organic Letters 2011, 13, 138–141: PMCID: PMC3014433
  “Total Synthesis of (+)-Nankakurines A and B and (±)-5-epi-Nankakurine A”
R. A. Altman, B. L. Nilsson, L. E. Overman, J. Read de Alaniz, J. M. Rohde and V. Taupin
Journal of Organic Chemistry 2010, 75, 7519–7534: PMCID: PMC3038189
  “Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters”
J. S. Cannon, S. F. Kirsch, L. E. Overman and H. F. Sneddon
Journal of the American Chemical Society 2010, 132, 15192–15203: PMCID: PMC 2967776
  “Catalytic Asymmetric Synthesis of Chiral Allylic Esters”
J. S. Cannon, S. F. Kirsch and L. E. Overman
Journal of the American Chemical Society 2010, 132, 15185–15191: PMCID: PMC 2966826
American Chemical Society
American Association for the Advancement of Sciences
National Academy of Sciences
American Academy of Arts & Sciences
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Last updated 08/06/2015