Larry E. OvermanProfessor, Chemistry Distinguished Professor of Chemistry |
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Research Interests |
Organic, Inorganic, Organometallic and Chemical Biology | |
| URL | Overman Group Website | |
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Academic Distinctions | 2011 UCI Medal, University of California, Irvine, American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010, Tetrahedron Prize for Creativity in Organic Chemistry, 2008, The Nagoya Medal of Organic Chemistry, 2007, International Society of Heterocyclic Chemistry Senior Award, 2005, Ta-shue Chou Lectureship Award, 2004, American Chemical Society Arthur C. Cope Award, 2003, U.C. Irvine Distinguished Faculty Lectureship Award for Research, 2002-2003, Yamada Prize, 2002, 2000 Japan Society for the Promotion of Science Fellowship, 1999 S. T. Li Prize for Achievements in Science and Technology, Earlham College Distinguished Faculty Award 1999, Centenary Medal, Chemical Society, U.K., 1997, American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995, Guggenheim Fellowship, 1993-1994, C.S. Hamilton Award, University of Nebraska, 1993, Javits Neuroscience Investigator Award, 1985-1992; 1992-1999, American Chemical Society Arthur C. Cope Scholar Award, 1989, Visiting Miller Research Fellow, U.C. Berkeley, 1989, Alexander von Humboldt U.S. Senior Scientist Award, 1985-1987, Camille and Henry Dreyfus Teacher-Scholar Award, 1976-1981, U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981, U.C. Irvine Alumni Association Distinguished Research Award, 1979, Alfred P. Sloan Foundation Fellow, 1975-1977 | |
| Appointments |
NIH Postdoctoral Fellow, Columbia University, 1969-1971 Joined UCI Faculty in 1971 |
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Research Abstract |
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. We are involved also in collaborative programs in the areas of Golgi and cancer biology. | |
| Publications |
“Is There No End to the Total Syntheses of Strychnine? Lessons to be Learned for Strategy and Tactics in Total Synthesis” Jeffrey S. Cannon and Larry E. Overman Angewandte Chemie, International Edition 2012, 51, in press |
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“Enantioselective Total Synthesis of Aplyviolene” Larry E. Overman and Martin J. Schnermann Journal of the American Chemical Society 2011, 133, 16425–16427 PMCID: PMC3205941 |
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“Divergent Synthesis and Chemical Reactivity of Bicyclic Lactone Fragments of Complex Rearranged Spongian Diterpenes” Martin J. Schnermann, Christopher M. Beaudry, Nathan E. Genung, Stephen M. Canham, Nicholas L. Untiedt, Breanne D. W. Karanikolas, Christine Sütterlin and Larry E. Overman Journal of the American Chemical Society 2011, 133, 17494–17503 PMCID: PMC3202687 |
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“Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ” Stephen M. Canham, Larry E. Overman and Paul S. Tanis Tetrahedron 2011, 67, 9837–9843 NIHMSID331433 |
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“Enantioselective Total Synthesis of (+)-Gliocladin C and (+)-Gliocladine C. A Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors” J. E. DeLorbe, S. Y. Jabri, S. M. Mennen, L. E. Overman and F-L Zhang Journal of the American Chemical Society 2011, 133, 6549–6552 PMCID: PMC3090078 |
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“Total Synthesis of (+)-Condylocarpine (+)-Isocondylocarpine, and (+)-Tubotaiwine” C. L. Martin, S. Nakamura, R. Otte and L. E. Overman Organic Letters 2011, 13, 138–141: PMCID: PMC3014433 |
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“Total Synthesis of (+)-Nankakurines A and B and (±)-5-epi-Nankakurine A” R. A. Altman, B. L. Nilsson, L. E. Overman, J. Read de Alaniz, J. M. Rohde and V. Taupin Journal of Organic Chemistry 2010, 75, 7519–7534: PMCID: PMC3038189 |
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“Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters” J. S. Cannon, S. F. Kirsch, L. E. Overman and H. F. Sneddon Journal of the American Chemical Society 2010, 132, 15192–15203: PMCID: PMC 2967776 |
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“Catalytic Asymmetric Synthesis of Chiral Allylic Esters” J. S. Cannon, S. F. Kirsch and L. E. Overman Journal of the American Chemical Society 2010, 132, 15185–15191: PMCID: PMC 2966826 |
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Professional Societies |
American Chemical Society American Association for the Advancement of Sciences National Academy of Sciences American Academy of Arts & Sciences |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2042 | |
| Last updated | 12/09/2011 | |