Henry Hirschberg

Picture of Henry Hirschberg
Researcher, Beckman Laser Institute and Medical Clinic
School of Medicine
Professor
M.D., University in Oslo, 1975
Ph.D., University in Oslo, 1975, Immunology
B.S., City University of New York, 1960, BEE
Phone: (949) 824-1248
Email: hhirschb@uci.edu
University of California, Irvine
1002 Health Sciences Road E
Irvine, CA 92697
Research Interests
Photodynamic therapy, brain tumors, neuroprotection, image guided surgery
Publications
153. Steen J. Madsen, , H. Michael Gach, Qian Peng Francisco A. Uzal, , Henry Hirschberg, (2013) Increased nanoparticle-loaded macrophage migration into the brain following PDT-induced blood-brain barrier disruption. Lasers Surg Med. Oct;45(8):524-32.
138. Hirschberg H, Sun CH, Krasieva T and Madsen SJ (2006) Effects of ALA-mediated photodynamic therapy on the invasiveness of human glioma cells. Lasers Surg Med. Dec;38(10):939-45.

139. Angell-Petersen E, Hirschberg, H and Madsen SJ (2007) Determination of fluence rate and temperature distributions in the rat brain; implications for photodynamic therapy. J.Biomedical Optics Jan-Feb;12(1):014003.

140. Madsen SJ, Kharkhuu K, Hirschberg H., (2007) “Utility of the F98 rat glioma model for photodynamic therapy.” Journal of Environmental Pathology, Toxicology and Oncology, 26(2), 149-155, 2007.

141. Hirschberg H, Wu GN, Madsen SJ.: Evaluation of Motexafin gadolinium (MGd) as a contrast agent for intraoperative MRI. Minim Invasive Neurosurg. 2007 Dec;50(6):318-23.

142. Hirschberg H, Uzal FA, Chighvinadze D, Zhang MJ, Peng Q, Madsen SJ. 2008 Disruption of the blood-brain barrier following ALA-mediated photodynamic therapy. Lasers Surg Med. Oct;40(8):535-42.

143. Madsen SJ, Mathews MS, Angell-Petersen E, Sun CH, Vo V, Sanchez R, Hirschberg H. (2009) Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids J. Neurooncol. 2009 Jan;91(2):141-9. Epub 2008 Sep 6.

144. Hirschberg H, Zhang MJ, Gach HM, Uzal FA, Chighvinadze D, Sun CH, Peng Q, Madsen SJ. (2009) Targeted delivery of bleomycin to the brain using photo- chemical internalization of Clostridium perfringens epsilon prototoxin. J Neurooncol. 2009 Dec;95(3):317-29. Epub 2009 Jun 9.

145. Mathews MS, Angell-Petersen E, Sanchez R, Sun CH, Vo V, Hirschberg H, Madsen SJ. The effects of ultra low fluence rate photodynamic therapy on glioma spheroids. Lasers Surg Med. 2009 Oct;41(8):578-84.

146. Madsen SJ, Hirschberg H. (2010) Site-specific opening of the blood-brain barrier.. J Biophotonics. Jun;3(5-6):356-67

147. Baek SK, Makkouk AR, Krasieva T, Sun CH, Madsen SJ, Hirschberg H. Photothermal treatment of glioma; an in vitro study of macrophage-mediated delivery of gold nanoshells. . J Neurooncol. 2011 Sep;104(2):439-48. Epub 2011 Jan 9.

148. Madsen SJ, Chio B, & Hirschberg H. Lasers in Diagnostics and Treatment of Brain Diseases. Book chapter Biomedical Photonics Handbook, CRC Press second edition (in press)

149. S J. Madsen, SK Baek, A R. Makkouk, T. Krasieva, and H Hirschberg (2011) Macrophages as cell-based delivery systems for nanoshells in photothermal therapy. Annals of Biomedical Engineering (ABME) Ann Biomed Eng. 2012 Feb;40(2):507-15. Epub 2011 Oct 7.

150. Mathews MS, Chighvinadze D, Gach HM, Uzal FA, Madsen SJ, Hirschberg H. Cerebral edema following photodynamic therapy using endogenous and exogenous photosensitizers in normal brain. Lasers Surg Med. 2011 Nov;43(9):892-900. doi: 10.1002/lsm.21135.

151. Mathews MS, Blickenstaff JW, Shih EC, Zamora G, Vo V, Sun CH, Hirschberg H, Madsen SJ. Photochemical internalization of bleomycin for glioma treatment. J Biomed Opt. 2012 May; 17(5):058001.

152. Mathews MS, Vo V, Shih EC, Zamora G, Sun CH, Madsen SJ, Hirschberg H. Photochemical internalization-mediated delivery of chemotherapeutic agents in human breast tumor cell lines. J Environ Pathol Toxicol Oncol. 2012;31(1):49-59.

153. Mathews MS, Shih EC, Zamora G, Sun CH, Cho SK , Kwon YJ, Hirschberg H , Glioma cell growth inhibition following photochemical internalization enhanced nonviral PTEN gene transfection. Lasers Surg Med. 2012 (in press)

Proceeding papers
30. Henry Hirschberg, Marlon S. Mathews, Even Angell-Petersen, Signe Spetalen and Steen J. Madsen, “Increased brain edema following 5-aminolevulinic acid administration mediated photodynamic therapy in normal and tumor-bearing rats,” Proceedings SPIE, vol. 6424, p. 64242B-1-8, Photonic Therapeutics and Diagnostics III, N. Kollias, et al. (Eds.) 2007.
31. Steen J. Madsen, Khishigzaya Kharkhuu, Kristian Berg, and Henry Hirschberg, “Photochemical internalization for the treatment of malignant gliomas,” Proceedings SPIE, vol. 6424, p. 64242C-1-6, Photonic Therapeutics and Diagnostics III, N. Kollias, et al. (Eds.) 2007.
32. Marlon S. Mathews, Chung-Ho Sun, Steen J. Madsen and Henry Hirschberg, “Comparing the effects of repetitive and chronic ALA-mediated PDT on human glioma spheroids,” Proceedings SPIE, vol. 6424, p. 64242D-1-9, Photonic Therapeutics and Diagnostics III, N. Kollias, et al. (Eds.) 2007.
33. Marlon S. Matthews, Rogelio C. Sanchez, Chung-Ho Sun, Steen J. Madsen, and Henry Hirschberg, “The effect of motexafin gadolinium of ALA photodynamic therapy in glioma spheroids,” Proceedings SPIE, vol. 6842, p. 68422N1-7, Photonic Therapeutics and Diagnostics IV, N. Kollias et al. (Eds.), 2008.
34. Henry Hirschberg, Michelle Zhang, David Chighvinadze, Qian Peng, and Steen J. Madsen, “Targeted opening of the blood brain barrier by ALA mediated PDT,” Proceedings SPIE, vol. 6842, p. 68422O1-11, Photonic Therapeutics and Diagnostics IV, N. Kollias et al. (Eds.), 2008
35. Steen J. Madsen, Genevieve N. Wu and Henry Hirschberg, “Evaluation of a novel gadolinium-based contrast agent for intraoperative magnetic resonance imaging,” Proceedings SPIE, vol. 6842, p. 68422R1-10, Photonic Therapeutics and Diagnostics IV, N. Kollias et al. (Eds.), 2008.
36. Henry Hirschberg Michelle J. Zhang, Michael H Gach, Francisco A. Uzal, David Chighvinadze, and Steen J Madsen; Selective Disruption of the Blood-Brain Barrier by Photochemical Internalization. Proceedings SPIE, Photonic Therapeutics and Diagnostics Proc. of SPIE Vol. 7161 716136-2
37. Steen J. Madsen, Joseph W. Blickenstaffa, Van Voa, Even Angell-Petersen and Henry Hirschberg Photochemical internalization enhances the efficacy of bleomycin in malignant glioma cells. Proceedings SPIE, Vol. 7161 716132 2009
38. Amani R. Makkouk, Henry Hirschberg, H. Michael Gach, and Steen J. Madsen,
Near-infrared-activated gold nanoshells for thermal ablation of macrophages in vitro. Proceedings SPIE, Photonic Therapeutics and Diagnostics 2010.
39. Henry Hirschberg, Seung-Kuk Baek ,Young Jik Kwon , Chung-Ho Sun and Steen J Madsen, ."Bypassing the blood brain barrier: delivery of therapeutic agents by macrophages". Proceedings SPIE, Photonic Therapeutics and Diagnostics 2010
40. Chih H. Chou, Chung-Ho Sun, Yi-Hong Zhou, Steen J. Madsen and Henry Hirschberg Enhanced transfection of brain tumor suppressor genes by photochemical internalization. Proceedings SPIE, Photonic Therapeutics and Diagnostics Vol 7883: 3U 2011.
41. Hirschberg H Seung-Kuk Baek , Young Jik Kwon , Chung-Ho Sun and Steen J Madsen. Photothermal ablation of malignant brain tumors by nanoparticle loaded macrophages. Photonic Therapeutics and Diagnostics Vol 7883: 3U1-10
42. Hirschberg H, Mathews MB, Shih EC , Madsen, SJ Kwon YJ (2012) Enhanced gene transfection by photochemical internalization of protomine sulfate/DNA complexes. Proceedings SPIE, Photonic Therapeutics and Diagnostics Vol.
43. Madsen SJ, Christin C, Andersen A, Molina S and Hirschberg H (2013) Effects of combined photochemical internalization and hyperthermia are sensitively dependent on radiant exposure. Proceedings SPIE, Photonic Therapeutics and Diagnostics Vol.
Grants
UCI Collaborative Research Grant 09/15/2012-09/15/2013 Co-I Efficient and Targeted Gene Therapy for Gliomas by Stimuli- Responsive and Photochemically Triggered Intracellular Release of Nanomedicine UCI Cancer Center seed grant 09/01/2012- 09/01/2013 PI Photochemical internalization (PCI) enhanced nonviral transfection of pro-drug activating genes; a potential treatment modality for gliomas. Evaluate photochemical internalization (PCI) as a method for the non-viral transfection of the cytosine deaminase (CD) suicide gene into gliomas cells. The (CD) gene encodes an enzyme that can convert the nontoxic antifungal agent, 5-fluorocytosine (5-FC), into the chemotherapeutic drug, 5-fluorouracil (5-FU) The Norwegian Radium Hospital Research Foundation 06/01/2012-06/01/2014 Co-PI Photochemical internalization (PCI) enhanced nonviral transfection of pro-drug activating genes; a potential treatment modality for gliomas. This is a collaborative effort between the Rikshospitalet-Radiumhospitalet (RH/DNR) Oslo Norway, and the Beckman Laser Institute and Medical Clinic (BLI), University of California, Irvine (UCI ) The overall objective of the research is to investigate the utility of photobiology for the treatment of malignant brain tumors (gliomas). We propose in this application the evaluation of photochemical internalization (PCI) as a method for the non-viral introduction of the prodrug cytosine deaminase (CD) suicide gene into gliomas cells. The Norwegian Radium Hospital Research Foundation 06/01/10-12/30/13 (Co-PI) Improved therapy of brain tumors with site specific blood brain barrier opening by photochemical internalization: mechanism and potentiation of chemotherapy. The specific aim of this proposal to evaluate photochemical internalization (PCI) as a method for both the selective and localized disruption of the blood brain barrier and the increased efficacy of chemotherapy.
Recently Completed Research ASLMS Research Grant 7/01/2011-6/32/2012 Co-I Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor genes; a potential treatment modality for gliomas. The objective of the research is the evaluation and optimization of photochemical internalization (PCI) as a method to increase transfection rates of tumor suppressor genes into malignant tumor cell lines as well as patient derived tumor stem cells (TSC). The Nevada Health Sciences System Research Grant 05/01/09 – 09/31/2011 Co-I Macrophage-mediated delivery of nanoparticles for photothermal ablation of malignant gliomas. The aims of this project are to examine a novel nanoparticle delivery approach and to use these particles for destruction of malignant gliomas via hyperthermia.
Professional Societies
1982-present member Scandinavian Neurosurgical Society
SPIE chairman, session optical methods in Neurosurgery SPIE
The Norwegian Medical Association
Research Centers
UNLV department of medical physics
Beckman Laser Institute
Last updated
03/06/2019